Differences in fMRI and MRS in a monozygotic twin pair discordant for schizophrenia (case report)

Filip Španiel; T. Hájek; J. Tintěra; P. Harantová; M. Dezortová; M. Hájek

doi:10.1034/j.1600-0447.2003.02430.x

Differences in fMRI and MRS in a monozygotic twin pair discordant for schizophrenia (case report)

Filip Španiel, T. Hájek, J. Tintěra, P. Harantová, M. Dezortová, M. Hájek

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Objective: This paper presents functional magnetic resonance imaging (fMRI) and magnetic resonance spectroscopy (MRS) findings in a monozygotic twin pair discordant for schizophrenia. Method: Functional magnetic resonance imaging was used to determine hemispheric lateralization for speech and proton MRS (¹H-MRS) was employed to assess the extent of putative insult to anterior hippocampus. Results: Despite concordant right handedness, subject with schizophrenia displayed bilateral activation in areas subserving speech with greater extent of the total activated area compared with the healthy twin. The affected twin displayed relative bilateral decrease in N-acetylaspartate/creatin concentration in the anterior hippocampus compared with the healthy one. Conclusion: This is an evidence for non-genetic impairment of cerebral lateralization in monozygotic twin with schizophrenia.

Original language	English
Pages (from-to)	155-158
Number of pages	4
Journal	Acta Psychiatrica Scandinavica
Volume	107
Issue number	2
DOIs	https://doi.org/10.1034/j.1600-0447.2003.02430.x
Publication status	Published - Feb 1 2003
Externally published	Yes

ASJC Scopus Subject Areas

Psychiatry and Mental health

PubMed: MeSH publication types

Case Reports
Journal Article

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1034/j.1600-0447.2003.02430.x

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Španiel, F., Hájek, T., Tintěra, J., Harantová, P., Dezortová, M., & Hájek, M. (2003). Differences in fMRI and MRS in a monozygotic twin pair discordant for schizophrenia (case report). Acta Psychiatrica Scandinavica, 107(2), 155-158. https://doi.org/10.1034/j.1600-0447.2003.02430.x

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AU - Hájek, T.

AU - Tintěra, J.

AU - Harantová, P.

AU - Dezortová, M.

AU - Hájek, M.

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N2 - Objective: This paper presents functional magnetic resonance imaging (fMRI) and magnetic resonance spectroscopy (MRS) findings in a monozygotic twin pair discordant for schizophrenia. Method: Functional magnetic resonance imaging was used to determine hemispheric lateralization for speech and proton MRS (1H-MRS) was employed to assess the extent of putative insult to anterior hippocampus. Results: Despite concordant right handedness, subject with schizophrenia displayed bilateral activation in areas subserving speech with greater extent of the total activated area compared with the healthy twin. The affected twin displayed relative bilateral decrease in N-acetylaspartate/creatin concentration in the anterior hippocampus compared with the healthy one. Conclusion: This is an evidence for non-genetic impairment of cerebral lateralization in monozygotic twin with schizophrenia.

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Differences in fMRI and MRS in a monozygotic twin pair discordant for schizophrenia (case report)

Abstract

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

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