Disruptive mood dysregulation disorder in offspring of parents with depression and bipolar disorder

Lukas Propper; Jill Cumby; Victoria C. Patterson; Vladislav Drobinin; Jacqueline M. Glover; Lynn E. MacKenzie; Jessica Morash-Conway; Sabina Abidi; Alexa Bagnell; David Lovas; Tomas Hajek; William Gardner; Kathleen Pajer; Martin Alda; Rudolf Uher

doi:10.1192/bjp.bp.117.198754

Disruptive mood dysregulation disorder in offspring of parents with depression and bipolar disorder

Lukas Propper, Jill Cumby, Victoria C. Patterson, Vladislav Drobinin, Jacqueline M. Glover, Lynn E. MacKenzie, Jessica Morash-Conway, Sabina Abidi, Alexa Bagnell, David Lovas, Tomas Hajek, William Gardner, Kathleen Pajer, Martin Alda, Rudolf Uher

Medicine

Research output: Contribution to journal › Review article › peer-review

16 Citations (Scopus)

Abstract

Background It has been suggested that offspring of parents with bipolar disorder are at increased risk for disruptive mood dysregulation disorder (DMDD), but the specificity of this association has not been established. Aims We examined the specificity of DMDD to family history by comparing offspring of parents with (a) bipolar disorder, (b) major depressive disorder and (c) a control group with no mood disorders. Method We established lifetime diagnosis of DMDD using the Schedule for Affective Disorders and Schizophrenia for School Aged Children for DSM-5 in 180 youth aged 6-18 years, including 58 offspring of parents with bipolar disorder, 82 offspring of parents with major depressive disorder and 40 control offspring. Results Diagnostic criteria for DMDD were met in none of the offspring of parents with bipolar disorder, 6 of the offspring of parents with major depressive disorder and none of the control offspring. DMDD diagnosis was significantly associated with family history of major depressive disorder. Conclusions Our results suggest that DMDD is not specifically associated with a family history of bipolar disorder and may be associated with parental depression.

Original language	English
Pages (from-to)	408-412
Number of pages	5
Journal	British Journal of Psychiatry
Volume	210
Issue number	6
DOIs	https://doi.org/10.1192/bjp.bp.117.198754
Publication status	Published - Jun 2017

Bibliographical note

Funding Information:
This work has been carried out thanks to funding from the Canadian Institutes of Health Research (funding reference numbers 124976, 142738, and 148394), the Nova Scotia Health Research Foundation, the Canada Research Chairs Program and the Dalhousie University Department of Psychiatry.

Publisher Copyright:
© The Royal College of Psychiatrists 2017.

ASJC Scopus Subject Areas

Psychiatry and Mental health

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1192/bjp.bp.117.198754

Cite this

Propper, L., Cumby, J., Patterson, V. C., Drobinin, V., Glover, J. M., MacKenzie, L. E., Morash-Conway, J., Abidi, S., Bagnell, A., Lovas, D., Hajek, T., Gardner, W., Pajer, K., Alda, M., & Uher, R. (2017). Disruptive mood dysregulation disorder in offspring of parents with depression and bipolar disorder. British Journal of Psychiatry, 210(6), 408-412. https://doi.org/10.1192/bjp.bp.117.198754

Propper, L, Cumby, J, Patterson, VC, Drobinin, V, Glover, JM, MacKenzie, LE, Morash-Conway, J, Abidi, S , Bagnell, A, Lovas, D, Hajek, T, Gardner, W, Pajer, K, Alda, M & Uher, R 2017, 'Disruptive mood dysregulation disorder in offspring of parents with depression and bipolar disorder', British Journal of Psychiatry, vol. 210, no. 6, pp. 408-412. https://doi.org/10.1192/bjp.bp.117.198754

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title = "Disruptive mood dysregulation disorder in offspring of parents with depression and bipolar disorder",

abstract = "Background It has been suggested that offspring of parents with bipolar disorder are at increased risk for disruptive mood dysregulation disorder (DMDD), but the specificity of this association has not been established. Aims We examined the specificity of DMDD to family history by comparing offspring of parents with (a) bipolar disorder, (b) major depressive disorder and (c) a control group with no mood disorders. Method We established lifetime diagnosis of DMDD using the Schedule for Affective Disorders and Schizophrenia for School Aged Children for DSM-5 in 180 youth aged 6-18 years, including 58 offspring of parents with bipolar disorder, 82 offspring of parents with major depressive disorder and 40 control offspring. Results Diagnostic criteria for DMDD were met in none of the offspring of parents with bipolar disorder, 6 of the offspring of parents with major depressive disorder and none of the control offspring. DMDD diagnosis was significantly associated with family history of major depressive disorder. Conclusions Our results suggest that DMDD is not specifically associated with a family history of bipolar disorder and may be associated with parental depression.",

author = "Lukas Propper and Jill Cumby and Patterson, {Victoria C.} and Vladislav Drobinin and Glover, {Jacqueline M.} and MacKenzie, {Lynn E.} and Jessica Morash-Conway and Sabina Abidi and Alexa Bagnell and David Lovas and Tomas Hajek and William Gardner and Kathleen Pajer and Martin Alda and Rudolf Uher",

note = "Funding Information: This work has been carried out thanks to funding from the Canadian Institutes of Health Research (funding reference numbers 124976, 142738, and 148394), the Nova Scotia Health Research Foundation, the Canada Research Chairs Program and the Dalhousie University Department of Psychiatry. Publisher Copyright: {\textcopyright} The Royal College of Psychiatrists 2017.",

year = "2017",

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doi = "10.1192/bjp.bp.117.198754",

language = "English",

volume = "210",

pages = "408--412",

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AU - Cumby, Jill

AU - Patterson, Victoria C.

AU - Drobinin, Vladislav

AU - Glover, Jacqueline M.

AU - MacKenzie, Lynn E.

AU - Morash-Conway, Jessica

AU - Abidi, Sabina

AU - Bagnell, Alexa

AU - Lovas, David

AU - Hajek, Tomas

AU - Gardner, William

AU - Pajer, Kathleen

AU - Alda, Martin

AU - Uher, Rudolf

N1 - Funding Information: This work has been carried out thanks to funding from the Canadian Institutes of Health Research (funding reference numbers 124976, 142738, and 148394), the Nova Scotia Health Research Foundation, the Canada Research Chairs Program and the Dalhousie University Department of Psychiatry. Publisher Copyright: © The Royal College of Psychiatrists 2017.

PY - 2017/6

Y1 - 2017/6

N2 - Background It has been suggested that offspring of parents with bipolar disorder are at increased risk for disruptive mood dysregulation disorder (DMDD), but the specificity of this association has not been established. Aims We examined the specificity of DMDD to family history by comparing offspring of parents with (a) bipolar disorder, (b) major depressive disorder and (c) a control group with no mood disorders. Method We established lifetime diagnosis of DMDD using the Schedule for Affective Disorders and Schizophrenia for School Aged Children for DSM-5 in 180 youth aged 6-18 years, including 58 offspring of parents with bipolar disorder, 82 offspring of parents with major depressive disorder and 40 control offspring. Results Diagnostic criteria for DMDD were met in none of the offspring of parents with bipolar disorder, 6 of the offspring of parents with major depressive disorder and none of the control offspring. DMDD diagnosis was significantly associated with family history of major depressive disorder. Conclusions Our results suggest that DMDD is not specifically associated with a family history of bipolar disorder and may be associated with parental depression.

AB - Background It has been suggested that offspring of parents with bipolar disorder are at increased risk for disruptive mood dysregulation disorder (DMDD), but the specificity of this association has not been established. Aims We examined the specificity of DMDD to family history by comparing offspring of parents with (a) bipolar disorder, (b) major depressive disorder and (c) a control group with no mood disorders. Method We established lifetime diagnosis of DMDD using the Schedule for Affective Disorders and Schizophrenia for School Aged Children for DSM-5 in 180 youth aged 6-18 years, including 58 offspring of parents with bipolar disorder, 82 offspring of parents with major depressive disorder and 40 control offspring. Results Diagnostic criteria for DMDD were met in none of the offspring of parents with bipolar disorder, 6 of the offspring of parents with major depressive disorder and none of the control offspring. DMDD diagnosis was significantly associated with family history of major depressive disorder. Conclusions Our results suggest that DMDD is not specifically associated with a family history of bipolar disorder and may be associated with parental depression.

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Disruptive mood dysregulation disorder in offspring of parents with depression and bipolar disorder

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

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