DISTRIBUTION OF α‐ AND β‐ADRENOCEPTORS IN HUMAN URINARY BLADDER

S. A. AWAD; A. W. BRUCE; G. CARRO‐CIAMPI; J. W. DOWNIE; M. LIN; G. S. MARKS

doi:10.1111/j.1476-5381.1974.tb08585.x

DISTRIBUTION OF α‐ AND β‐ADRENOCEPTORS IN HUMAN URINARY BLADDER

S. A. AWAD, A. W. BRUCE, G. CARRO‐CIAMPI, J. W. DOWNIE, M. LIN, G. S. MARKS

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103 Citations (Scopus)

Abstract

The distribution of α‐ and β‐adrenoceptors in isolated preparations of human bladder neck and detrusor muscle has been studied. Adrenaline caused contraction of the bladder neck which was blocked by phenoxybenzamine but unaltered by propranolol. Isoprenaline caused relaxation of the bladder neck which was blocked by propranolol. High concentrations caused contraction which was enhanced by propranolol but blocked by phenoxybenzamine. Detrusor muscle was relaxed by isoprenaline and this effect was blocked by propranolol. Phenylephrine caused relaxation of detrusor which was unaffected by phenoxybenzamine; in some cases contraction was produced in the presence of propranolol. It is concluded that the bladder neck contains mainly α‐receptors and the detrusor mainly β‐receptors but both regions possess both types of adrenoceptor. 1974 British Pharmacological Society

Original language	English
Pages (from-to)	525-529
Number of pages	5
Journal	British Journal of Pharmacology
Volume	50
Issue number	4
DOIs	https://doi.org/10.1111/j.1476-5381.1974.tb08585.x
Publication status	Published - Apr 1974
Externally published	Yes

ASJC Scopus Subject Areas

Pharmacology

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title = "DISTRIBUTION OF α‐ AND β‐ADRENOCEPTORS IN HUMAN URINARY BLADDER",

abstract = "The distribution of α‐ and β‐adrenoceptors in isolated preparations of human bladder neck and detrusor muscle has been studied. Adrenaline caused contraction of the bladder neck which was blocked by phenoxybenzamine but unaltered by propranolol. Isoprenaline caused relaxation of the bladder neck which was blocked by propranolol. High concentrations caused contraction which was enhanced by propranolol but blocked by phenoxybenzamine. Detrusor muscle was relaxed by isoprenaline and this effect was blocked by propranolol. Phenylephrine caused relaxation of detrusor which was unaffected by phenoxybenzamine; in some cases contraction was produced in the presence of propranolol. It is concluded that the bladder neck contains mainly α‐receptors and the detrusor mainly β‐receptors but both regions possess both types of adrenoceptor. 1974 British Pharmacological Society",

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AU - AWAD, S. A.

AU - BRUCE, A. W.

AU - CARRO‐CIAMPI, G.

AU - DOWNIE, J. W.

AU - LIN, M.

AU - MARKS, G. S.

PY - 1974/4

Y1 - 1974/4

N2 - The distribution of α‐ and β‐adrenoceptors in isolated preparations of human bladder neck and detrusor muscle has been studied. Adrenaline caused contraction of the bladder neck which was blocked by phenoxybenzamine but unaltered by propranolol. Isoprenaline caused relaxation of the bladder neck which was blocked by propranolol. High concentrations caused contraction which was enhanced by propranolol but blocked by phenoxybenzamine. Detrusor muscle was relaxed by isoprenaline and this effect was blocked by propranolol. Phenylephrine caused relaxation of detrusor which was unaffected by phenoxybenzamine; in some cases contraction was produced in the presence of propranolol. It is concluded that the bladder neck contains mainly α‐receptors and the detrusor mainly β‐receptors but both regions possess both types of adrenoceptor. 1974 British Pharmacological Society

AB - The distribution of α‐ and β‐adrenoceptors in isolated preparations of human bladder neck and detrusor muscle has been studied. Adrenaline caused contraction of the bladder neck which was blocked by phenoxybenzamine but unaltered by propranolol. Isoprenaline caused relaxation of the bladder neck which was blocked by propranolol. High concentrations caused contraction which was enhanced by propranolol but blocked by phenoxybenzamine. Detrusor muscle was relaxed by isoprenaline and this effect was blocked by propranolol. Phenylephrine caused relaxation of detrusor which was unaffected by phenoxybenzamine; in some cases contraction was produced in the presence of propranolol. It is concluded that the bladder neck contains mainly α‐receptors and the detrusor mainly β‐receptors but both regions possess both types of adrenoceptor. 1974 British Pharmacological Society

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DISTRIBUTION OF α‐ AND β‐ADRENOCEPTORS IN HUMAN URINARY BLADDER

Abstract

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