TY - JOUR
T1 - Dose effect of soy supplementation in prostate cancer
T2 - A pilot study
AU - Van Veldhuizen, Peter J.
AU - Thrasher, J. Brantley
AU - Ray, Gibanananda
AU - Cherian, Rachel
AU - Ward, Jan
AU - Holzbeierlein, Jeffrey
AU - Gutow, Stefan
AU - Banerjee, Sushanta K.
PY - 2006/12
Y1 - 2006/12
N2 - We performed a pilot study to determine the dose effect of soy supplement on serum hormonal levels, estrogen receptor α (ERα) and androgen receptor (AR) expression in patients scheduled to undergo prostatectomy. Cohorts of 3-4 eligible patients received escalating doses of a commercial soy supplement, Flav-ein, from the time of study enrollment until prostatectomy. Serum levels of prostate specific antigen (PSA), testosterone, and estrogen were measured at study enrollment and prior to prostatectomy. AR and ERα expression was evaluated in the pretreatment biopsy specimen and post-treatment prostatectomy specimen using immunohistochemical analysis. A total of 13 patients were enrolled in this pilot study and 11 patients were assessable for response. With soy supplementation, serum testosterone levels decreased in 9 of 11 patients and estrogen levels decreased in 8 of 10 patients in a dose-dependent manner. There was a variable effect on ERα expression with downregulation of receptor expression seen at the highest dose level. There was no effect on AR expression. In conclusion, supplementation with this commercial soy product produced a consistent decrease in serum sex hormone levels. Additional studies are needed to evaluate a potential dose effect on ERα expression.
AB - We performed a pilot study to determine the dose effect of soy supplement on serum hormonal levels, estrogen receptor α (ERα) and androgen receptor (AR) expression in patients scheduled to undergo prostatectomy. Cohorts of 3-4 eligible patients received escalating doses of a commercial soy supplement, Flav-ein, from the time of study enrollment until prostatectomy. Serum levels of prostate specific antigen (PSA), testosterone, and estrogen were measured at study enrollment and prior to prostatectomy. AR and ERα expression was evaluated in the pretreatment biopsy specimen and post-treatment prostatectomy specimen using immunohistochemical analysis. A total of 13 patients were enrolled in this pilot study and 11 patients were assessable for response. With soy supplementation, serum testosterone levels decreased in 9 of 11 patients and estrogen levels decreased in 8 of 10 patients in a dose-dependent manner. There was a variable effect on ERα expression with downregulation of receptor expression seen at the highest dose level. There was no effect on AR expression. In conclusion, supplementation with this commercial soy product produced a consistent decrease in serum sex hormone levels. Additional studies are needed to evaluate a potential dose effect on ERα expression.
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U2 - 10.3892/or.16.6.1221
DO - 10.3892/or.16.6.1221
M3 - Article
C2 - 17089041
AN - SCOPUS:34548463446
SN - 1021-335X
VL - 16
SP - 1221
EP - 1224
JO - Oncology Reports
JF - Oncology Reports
IS - 6
ER -
