Doxorubicin-loaded polyphosphate glass microspheres for transarterial chemoembolization

Hayden P. Nix, Arash Momeni, Daniel M. Chevrier, Catherine A. Whitman, Mark J. Filiaggi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The standard of care for intermediate stage hepatocellular carcinoma is transarterial chemoembolization (TACE). Drug-eluting bead TACE (DEB-TACE) has emerged as a leading form of TACE, as it uses highly calibrated microspheres to deliver consistent embolization and controlled drug release to the tumor microenvironment. We report here on doxorubicin (DOX)-loaded polyphosphate glass microspheres (PGM) as a novel resorbable, radiopaque, preloaded DEB-TACE platform. Coacervate composed of polyphosphate chains complexed with Ba2+, Ca2+, and Cu2+ can be loaded with DOX prior to PGM synthesis, with PGM production achieved using a water-in-oil emulsion technique at room temperature yielding highly spherical particles in clinically relevant size fractions. In vitro, DOX release was found to be linear, pH dependent, and in accordance with Type II non-Fickian transport. PGM degradation was characterized by an initial burst release of degradation products over 7 days, followed by a plateau in mass loss at approximately 75% over a period of several weeks. in vitro studies indicate that PGM degradation products, namely Cu2+, are cytotoxic and may interact with eluted DOX to impair its pharmacological activity. With additional compositional considerations, this approach may prove promising for DEB-TACE applications.

Original languageEnglish
Pages (from-to)2621-2632
Number of pages12
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume108
Issue number6
DOIs
Publication statusPublished - Aug 1 2020

Bibliographical note

Funding Information:
The authors gratefully acknowledge funding from the Natural Sciences and Engineering Research Council of Canada and the Beatrice Hunter Cancer Research Institute Cancer Research Training Program. The authors would also like to thank Dr. Alicia Oickle and Dr. Giban Ray from the Department of Applied Oral Sciences at Dalhousie University for their technical expertise, and Ms. Patricia Scallion from the Department of Mechanical Engineering at Dalhousie University for assisting with SEM.

Publisher Copyright:
© 2020 Wiley Periodicals, Inc.

ASJC Scopus Subject Areas

  • Biomaterials
  • Biomedical Engineering

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

Fingerprint

Dive into the research topics of 'Doxorubicin-loaded polyphosphate glass microspheres for transarterial chemoembolization'. Together they form a unique fingerprint.

Cite this