Dysfunctional temporal stages of eye-gaze perception in adults with ADHD: A high-density EEG study

Cheyenne Mauriello; Eleonore Pham; Samika Kumar; Camille Piguet; Marie Pierre Deiber; Jean Michel Aubry; Alexandre Dayer; Christoph M. Michel; Nader Perroud; Cristina Berchio

doi:10.1016/j.biopsycho.2022.108351

Dysfunctional temporal stages of eye-gaze perception in adults with ADHD: A high-density EEG study

Cheyenne Mauriello, Eleonore Pham, Samika Kumar, Camille Piguet, Marie Pierre Deiber, Jean Michel Aubry, Alexandre Dayer, Christoph M. Michel, Nader Perroud, Cristina Berchio

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

ADHD has been associated with social cognitive impairments across the lifespan, but no studies have specifically addressed the presence of abnormalities in eye-gaze processing in the adult brain. This study investigated the neural basis of eye-gaze perception in adults with ADHD using event-related potentials (ERP). Twenty-three ADHD and 23 controls performed a delayed face-matching task with neutral faces that had either direct or averted gaze. ERPs were classified using microstate analyses. ADHD and controls displayed similar P100 and N170 microstates. ADHD was associated with cluster abnormalities in the attention-sensitive P200 to direct gaze, and in the N250 related to facial recognition. For direct gaze, source localization revealed reduced activity in ADHD for the P200 in the left/midline cerebellum, as well as in a cingulate-occipital network at the N250. These results suggest brain impairments involving eye-gaze decoding in adults with ADHD, suggestive of neural signatures associated with this disorder in adulthood.

Original language	English
Article number	108351
Journal	Biological Psychology
Volume	171
DOIs	https://doi.org/10.1016/j.biopsycho.2022.108351
Publication status	Published - May 2022
Externally published	Yes

Bibliographical note

Funding Information:
The study was supported by the Swiss National Center of Competence in Research [“Synapsy: the Synaptic Basis of Mental Diseases” no.: 51NF40–158776; and grant no.: 32003B_156914]. The Cartool software is a freely available academic software that has been programmed by Denis Brunet (https://sites.google.com/site/cartoolcommunity/).

Funding Information:
The study was supported by the Swiss National Center of Competence in Research [“Synapsy: the Synaptic Basis of Mental Diseases” no.: 51NF40–158776 ; and grant no.: 32003B_156914 ]. The Cartool software is a freely available academic software that has been programmed by Denis Brunet ( https://sites.google.com/site/cartoolcommunity/ ).

Publisher Copyright:
© 2022 The Authors

ASJC Scopus Subject Areas

General Neuroscience
Neuropsychology and Physiological Psychology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

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10.1016/j.biopsycho.2022.108351

Cite this

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title = "Dysfunctional temporal stages of eye-gaze perception in adults with ADHD: A high-density EEG study",

abstract = "ADHD has been associated with social cognitive impairments across the lifespan, but no studies have specifically addressed the presence of abnormalities in eye-gaze processing in the adult brain. This study investigated the neural basis of eye-gaze perception in adults with ADHD using event-related potentials (ERP). Twenty-three ADHD and 23 controls performed a delayed face-matching task with neutral faces that had either direct or averted gaze. ERPs were classified using microstate analyses. ADHD and controls displayed similar P100 and N170 microstates. ADHD was associated with cluster abnormalities in the attention-sensitive P200 to direct gaze, and in the N250 related to facial recognition. For direct gaze, source localization revealed reduced activity in ADHD for the P200 in the left/midline cerebellum, as well as in a cingulate-occipital network at the N250. These results suggest brain impairments involving eye-gaze decoding in adults with ADHD, suggestive of neural signatures associated with this disorder in adulthood.",

author = "Cheyenne Mauriello and Eleonore Pham and Samika Kumar and Camille Piguet and Deiber, {Marie Pierre} and Aubry, {Jean Michel} and Alexandre Dayer and Michel, {Christoph M.} and Nader Perroud and Cristina Berchio",

note = "Funding Information: The study was supported by the Swiss National Center of Competence in Research [“Synapsy: the Synaptic Basis of Mental Diseases” no.: 51NF40–158776; and grant no.: 32003B_156914]. The Cartool software is a freely available academic software that has been programmed by Denis Brunet (https://sites.google.com/site/cartoolcommunity/). Funding Information: The study was supported by the Swiss National Center of Competence in Research [“Synapsy: the Synaptic Basis of Mental Diseases” no.: 51NF40–158776 ; and grant no.: 32003B_156914 ]. The Cartool software is a freely available academic software that has been programmed by Denis Brunet ( https://sites.google.com/site/cartoolcommunity/ ). Publisher Copyright: {\textcopyright} 2022 The Authors",

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AU - Aubry, Jean Michel

AU - Dayer, Alexandre

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AU - Perroud, Nader

AU - Berchio, Cristina

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Dysfunctional temporal stages of eye-gaze perception in adults with ADHD: A high-density EEG study

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Access to Document

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