TY - JOUR
T1 - Early course of bipolar disorder in high-risk offspring
T2 - Prospective study
AU - Duffy, Anne
AU - Alda, Martin
AU - Hajek, Tomas
AU - Grof, Paul
PY - 2009
Y1 - 2009
N2 - We studied the course of major mood disorders in the offspring of parents with well-characterised bipolar disorder prospectively for up to 15 years. All consenting offspring were assessed annually or anytime symptomatic. The participants began to develop major mood episodes in adolescence and not before. The index major mood episode was almost always depressive, as were the first few recurrences. Onsets and recurrences continued throughout the observation period into adulthood. We did not find evidence of pre-pubertal mania, In summary, adolescence marks the beginning of the high-risk period for major mood episodes related to bipolar disorder.
AB - We studied the course of major mood disorders in the offspring of parents with well-characterised bipolar disorder prospectively for up to 15 years. All consenting offspring were assessed annually or anytime symptomatic. The participants began to develop major mood episodes in adolescence and not before. The index major mood episode was almost always depressive, as were the first few recurrences. Onsets and recurrences continued throughout the observation period into adulthood. We did not find evidence of pre-pubertal mania, In summary, adolescence marks the beginning of the high-risk period for major mood episodes related to bipolar disorder.
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UR - http://www.scopus.com/inward/citedby.url?scp=70450197768&partnerID=8YFLogxK
U2 - 10.1192/bjp.bp.108.062810
DO - 10.1192/bjp.bp.108.062810
M3 - Article
C2 - 19880938
AN - SCOPUS:70450197768
SN - 0007-1250
VL - 195
SP - 457
EP - 458
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
IS - 5
ER -
