Abstract
Background and purpose: To improve diagnoses of primary brain tumours, knowledge about early indicators is needed. Nationwide Danish health registries were used to conduct a population-based case–control study including all persons diagnosed with a primary brain tumour between 2005 and 2014 in Denmark. Methods: All 5135 adults diagnosed with a primary brain tumour in the Danish Cancer Registry were matched to 19 572 general population comparisons from the Danish Civil Registration System. Conditional logistic regression analyses were applied to estimate age- and multivariable-adjusted odds ratios (ORs) for the occurrence of a primary brain tumour up to 10 years after hospital diagnoses or prescription of medications related to nervous system diseases and mental and behavioural disorders. Results: Increased odds for primary brain tumour after nervous system diseases and mental and behavioural disorders manifested up to 10 years before tumour diagnosis were found. Increased odds were seen especially for hospital contacts for inflammatory nervous system diseases [OR 11.3; 95% confidence interval (CI) 6.5–19.7], epilepsy (OR 9.0; 95% CI 7.6–10.7) and antiepileptic medications (OR 3.6; 95% CI 3.2–4.0), whilst antidementia medications provided a strong, protective association for primary brain tumours (OR 0.5; 95% CI 0.3–0.8). Conclusions: Sub-groups of patients diagnosed with or being prescribed certain medications targeting nervous system diseases and mental and behavioural disorders may be at increased risk of being diagnosed with a primary brain tumour. Further studies should disentangle the potential underlying common pathogenetic pathways. The results are important for the development of systematic clinical approaches to ensure early diagnosis of primary brain tumours.
Original language | English |
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Pages (from-to) | 278-285 |
Number of pages | 8 |
Journal | European Journal of Neurology |
Volume | 28 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2021 |
Bibliographical note
Funding Information:The authors acknowledge all the funders contributing to the development of this study: Helen Rudes Fond, Nordsjællands Hospital, Grosserer A. V. Lykfeldt og Hustrus Legat, and Sanatorielæge Ellen Pedersens Legat.
Publisher Copyright:
© 2020 European Academy of Neurology
ASJC Scopus Subject Areas
- Neurology
- Clinical Neurology
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't