Effect of high-volume cardioplegia on small-amplitude electrical activity during cardioplegia arrest

R. W. Landymore; A. E. Marble; P. Eng; M. A. Macaulay; A. Trillo; Q. Y. Li

doi:10.1016/1010-7940(91)90182-J

Effect of high-volume cardioplegia on small-amplitude electrical activity during cardioplegia arrest

R. W. Landymore, A. E. Marble, P. Eng, M. A. Macaulay, A. Trillo, Q. Y. Li

Medicine

Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of high-volume cardioplegia on the presence of smaii-ampiitude eiectricai activity during cardiopiegia arrest were investigated in 19 mongrel dogs. The animals were randomly assigned to receive either high-volume cystalloid cardioplegia guided by continuous electrical monitoring (V-plege). Cardiac index, left ventricular stroke work index dp/dt, and myocardial oxygen consumption were measured before bypass and following 90 min ischemia and 45 min reperfusion.ischemia and 45 min reperfusion. Biopsies were taken for measurement of adenosine triphosphate (ATP) and examination of myocardial ultrastructure. Nine animals received HV-plege, while the remaining 10 animals received cardioplegia guided by voltage criteria. Small-amplitude electrical potentials were recorded within 10-15 min after the infusion Of cardioplegia in all animals receiving cardioplegia guided by voltage criteria. Electrica activity, however, was immediately aboliShed by reinfusion of cardioplegia. HV-plege reduced the incidence of small-amplitude ele'ctrical activity during cardioplegia arrest but did not prevent electrical activity. Left ventricular function and myocardial ultrastructure werehetter presirved when cardioplegia was guided by electrical monitoring. ATP decreased similarly in both groups following cardioplegie arrest^ but myocardial oxygen Consumption was significantly higher following the arrest in_ the V-plege group. Conclusions: HV-plege does not prevent small-amplitude electiical activity and may have adverse effects on myocardial metabolic and funCtional recovery.

Original language	English
Pages (from-to)	395-399
Number of pages	5
Journal	European Journal of Cardio-thoracic Surgery
Volume	5
Issue number	8
DOIs	https://doi.org/10.1016/1010-7940(91)90182-J
Publication status	Published - Aug 1991

Bibliographical note

Funding Information:
Received for publication: December 12, 1990 Accepted for publication: March 14, 1991 Animals were cared for in accordance with the Guidelines set forth by the Canadian Council on Animal Care * Supported by a Medical Research Council grant

ASJC Scopus Subject Areas

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

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10.1016/1010-7940(91)90182-J

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title = "Effect of high-volume cardioplegia on small-amplitude electrical activity during cardioplegia arrest",

abstract = "The effects of high-volume cardioplegia on the presence of smaii-ampiitude eiectricai activity during cardiopiegia arrest were investigated in 19 mongrel dogs. The animals were randomly assigned to receive either high-volume cystalloid cardioplegia guided by continuous electrical monitoring (V-plege). Cardiac index, left ventricular stroke work index dp/dt, and myocardial oxygen consumption were measured before bypass and following 90 min ischemia and 45 min reperfusion.ischemia and 45 min reperfusion. Biopsies were taken for measurement of adenosine triphosphate (ATP) and examination of myocardial ultrastructure. Nine animals received HV-plege, while the remaining 10 animals received cardioplegia guided by voltage criteria. Small-amplitude electrical potentials were recorded within 10-15 min after the infusion Of cardioplegia in all animals receiving cardioplegia guided by voltage criteria. Electrica activity, however, was immediately aboliShed by reinfusion of cardioplegia. HV-plege reduced the incidence of small-amplitude ele'ctrical activity during cardioplegia arrest but did not prevent electrical activity. Left ventricular function and myocardial ultrastructure werehetter presirved when cardioplegia was guided by electrical monitoring. ATP decreased similarly in both groups following cardioplegie arrest^ but myocardial oxygen Consumption was significantly higher following the arrest in_ the V-plege group. Conclusions: HV-plege does not prevent small-amplitude electiical activity and may have adverse effects on myocardial metabolic and funCtional recovery.",

author = "Landymore, {R. W.} and Marble, {A. E.} and P. Eng and Macaulay, {M. A.} and A. Trillo and Li, {Q. Y.}",

note = "Funding Information: Received for publication: December 12, 1990 Accepted for publication: March 14, 1991 Animals were cared for in accordance with the Guidelines set forth by the Canadian Council on Animal Care * Supported by a Medical Research Council grant",

year = "1991",

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doi = "10.1016/1010-7940(91)90182-J",

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AU - Landymore, R. W.

AU - Marble, A. E.

AU - Eng, P.

AU - Macaulay, M. A.

AU - Trillo, A.

AU - Li, Q. Y.

N1 - Funding Information: Received for publication: December 12, 1990 Accepted for publication: March 14, 1991 Animals were cared for in accordance with the Guidelines set forth by the Canadian Council on Animal Care * Supported by a Medical Research Council grant

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Y1 - 1991/8

N2 - The effects of high-volume cardioplegia on the presence of smaii-ampiitude eiectricai activity during cardiopiegia arrest were investigated in 19 mongrel dogs. The animals were randomly assigned to receive either high-volume cystalloid cardioplegia guided by continuous electrical monitoring (V-plege). Cardiac index, left ventricular stroke work index dp/dt, and myocardial oxygen consumption were measured before bypass and following 90 min ischemia and 45 min reperfusion.ischemia and 45 min reperfusion. Biopsies were taken for measurement of adenosine triphosphate (ATP) and examination of myocardial ultrastructure. Nine animals received HV-plege, while the remaining 10 animals received cardioplegia guided by voltage criteria. Small-amplitude electrical potentials were recorded within 10-15 min after the infusion Of cardioplegia in all animals receiving cardioplegia guided by voltage criteria. Electrica activity, however, was immediately aboliShed by reinfusion of cardioplegia. HV-plege reduced the incidence of small-amplitude ele'ctrical activity during cardioplegia arrest but did not prevent electrical activity. Left ventricular function and myocardial ultrastructure werehetter presirved when cardioplegia was guided by electrical monitoring. ATP decreased similarly in both groups following cardioplegie arrest^ but myocardial oxygen Consumption was significantly higher following the arrest in_ the V-plege group. Conclusions: HV-plege does not prevent small-amplitude electiical activity and may have adverse effects on myocardial metabolic and funCtional recovery.

AB - The effects of high-volume cardioplegia on the presence of smaii-ampiitude eiectricai activity during cardiopiegia arrest were investigated in 19 mongrel dogs. The animals were randomly assigned to receive either high-volume cystalloid cardioplegia guided by continuous electrical monitoring (V-plege). Cardiac index, left ventricular stroke work index dp/dt, and myocardial oxygen consumption were measured before bypass and following 90 min ischemia and 45 min reperfusion.ischemia and 45 min reperfusion. Biopsies were taken for measurement of adenosine triphosphate (ATP) and examination of myocardial ultrastructure. Nine animals received HV-plege, while the remaining 10 animals received cardioplegia guided by voltage criteria. Small-amplitude electrical potentials were recorded within 10-15 min after the infusion Of cardioplegia in all animals receiving cardioplegia guided by voltage criteria. Electrica activity, however, was immediately aboliShed by reinfusion of cardioplegia. HV-plege reduced the incidence of small-amplitude ele'ctrical activity during cardioplegia arrest but did not prevent electrical activity. Left ventricular function and myocardial ultrastructure werehetter presirved when cardioplegia was guided by electrical monitoring. ATP decreased similarly in both groups following cardioplegie arrest^ but myocardial oxygen Consumption was significantly higher following the arrest in_ the V-plege group. Conclusions: HV-plege does not prevent small-amplitude electiical activity and may have adverse effects on myocardial metabolic and funCtional recovery.

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Effect of high-volume cardioplegia on small-amplitude electrical activity during cardioplegia arrest

Abstract

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