Effect of schisanhenol on the antitumor activity of adriamycin

Tong Jun Lin; Geng Tao Liu

doi:10.1016/0006-291X(91)91800-R

Effect of schisanhenol on the antitumor activity of adriamycin

Tong Jun Lin, Geng Tao Liu

Research output: Contribution to journal › Article › peer-review

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Abstract

Schisanhenol (Sal) did not diminish the antitumor activity of adriamycin in mice bearing P388 ascites tumor. Sal did not antagonize the the suppressive effect of adriamycin on DNA synthesis and cell proliferation in an L1210 ascitic tumor cell culture. Furthermore, Sal at the concentration of 0.1, 0.25, or 1 mM accelerated adriamycin-dependent DNA damage in the presence of Fe³⁺ in vitro. It appears that Sal was able to protect against adriamycin induced heart mitochondrial toxicity, while it did not antagonize the antitumor activity of adriamycin.

Original language	English
Pages (from-to)	207-212
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	178
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(91)91800-R
Publication status	Published - Jul 15 1991
Externally published	Yes

ASJC Scopus Subject Areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

PubMed: MeSH publication types

Journal Article

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10.1016/0006-291X(91)91800-R

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title = "Effect of schisanhenol on the antitumor activity of adriamycin",

abstract = "Schisanhenol (Sal) did not diminish the antitumor activity of adriamycin in mice bearing P388 ascites tumor. Sal did not antagonize the the suppressive effect of adriamycin on DNA synthesis and cell proliferation in an L1210 ascitic tumor cell culture. Furthermore, Sal at the concentration of 0.1, 0.25, or 1 mM accelerated adriamycin-dependent DNA damage in the presence of Fe3+ in vitro. It appears that Sal was able to protect against adriamycin induced heart mitochondrial toxicity, while it did not antagonize the antitumor activity of adriamycin.",

author = "Lin, {Tong Jun} and Liu, {Geng Tao}",

year = "1991",

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doi = "10.1016/0006-291X(91)91800-R",

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AU - Liu, Geng Tao

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Y1 - 1991/7/15

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AB - Schisanhenol (Sal) did not diminish the antitumor activity of adriamycin in mice bearing P388 ascites tumor. Sal did not antagonize the the suppressive effect of adriamycin on DNA synthesis and cell proliferation in an L1210 ascitic tumor cell culture. Furthermore, Sal at the concentration of 0.1, 0.25, or 1 mM accelerated adriamycin-dependent DNA damage in the presence of Fe3+ in vitro. It appears that Sal was able to protect against adriamycin induced heart mitochondrial toxicity, while it did not antagonize the antitumor activity of adriamycin.

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Effect of schisanhenol on the antitumor activity of adriamycin

Abstract

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