Effects of a Lifestyle Intervention in Young Women with GDM and Subsequent Diabetes

Gang Hu, Huikun Liu, Junhong Leng, Leishen Wang, Weiqin Li, Shuang Zhang, Wei Li, Gongshu Liu, Huiguang Tian, Shengping Yang, Zhijie Yu, Xilin Yang, Jaakko Tuomilehto

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The purpose of this study was to examine whether a 9-month intensive lifestyle intervention could lead to weight loss and improve cardiovascular risk factors among young women with both gestational diabetes mellitus (GDM) and newly diagnosed diabetes. A total of 83 young women, who had GDM and were subsequently diagnosed as type 2 diabetes at an average of 2.6 years after delivery, participated in a 9-month intensive lifestyle intervention and a follow-up survey at 6-9 years postintervention. After the 9-month intervention, these women had a weight loss of 2.90 kg (-4.02% of initial weight), decreased waist circumference (-3.12 cm), body fat (-1.75%), diastolic blood pressure (-3.49 mmHg), fasting glucose (-0.98 mmol/L) and HbA1c (-0.72%). During the 6-9 years postintervention period, they still had lower weight (-3.71 kg; -4.62% of initial weight), decreased waist circumference (-4.56 cm) and body fat (-2.10%), but showed a slight increase in HbA1c (0.22%). The prevalence of using glucose-lowering agents increased from 2.4% at baseline to 34.6% after the 9-month lifestyle intervention, and to 48.4% at 6-9 years postintervention. A 9-month intensive lifestyle intervention can produce beneficial effects on body weight, HbA1c and other cardiovascular risk factors among young women with previous GDM who subsequently developed new diabetes.

Original languageEnglish
JournalNutrients
Volume14
Issue number24
DOIs
Publication statusPublished - Dec 8 2022

ASJC Scopus Subject Areas

  • Food Science
  • Nutrition and Dietetics

PubMed: MeSH publication types

  • Journal Article

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