Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity: The hearty randomized controlled trial

Gary S. Goldfield; Glen P. Kenny; Denis Prud'homme; Martin Holcik; Angela S. Alberga; Margaret Fahnestock; Jameason D. Cameron; Steve Doucette; Stasia Hadjiyannakis; Heather Tulloch; Mark S. Tremblay; Jeremy Walsh; Eva Guerin; Katie E. Gunnell; Amedeo D'Angiulli; Ronald J. Sigal

doi:10.1016/j.physbeh.2018.04.026

Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity: The hearty randomized controlled trial

Gary S. Goldfield, Glen P. Kenny, Denis Prud'homme, Martin Holcik, Angela S. Alberga, Margaret Fahnestock, Jameason D. Cameron, Steve Doucette, Stasia Hadjiyannakis, Heather Tulloch, Mark S. Tremblay, Jeremy Walsh, Eva Guerin, Katie E. Gunnell, Amedeo D'Angiulli, Ronald J. Sigal

Medicine

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Brain derived neurotrophic factor (BDNF) is a protein that plays a critical role in modulating cognition in animals and humans. Aerobic exercise often increases BDNF in adults, but effects of this exercise modality and others among adolescents remain uncertain. This study examined the effects of aerobic training, resistance training, and combined training on resting serum BDNF levels in adolescents with overweight and obesity. After a 4-week pre-randomization treatment, 304 post-pubertal, adolescents with overweight or obesity (70% females) aged 14–18 years were randomized to one of four groups for 22 weeks: aerobic training (N = 75), resistance training (N = 78), combined aerobic and resistance training (N = 75), or non-exercising control (N = 76). All participants received dietary counseling targeting a daily energy deficit of 250 kcal. The exercise prescription was 4 times per week, progressing to 45 min/session for the aerobic and resistance groups and 90 min/session for the combined group. Resting serum BDNF levels were measured at baseline and 6-months. Results showed that in both intention-to-treat (ITT) and per protocol (≥70% adherence to prescribed sessions) analyses, there were no significant within- or between-group changes in BDNF. Findings indicate that aerobic training, resistance training or their combination did change serum BDNF levels in adolescents with overweight and obesity. Trial Registration: ClinicalTrials.Gov NCT00195858 http://clinicaltrials.gov/show/NCT00195858, September 12, 2005 (Funded by the Canadian Institutes of Health Research).

Original language	English
Pages (from-to)	138-145
Number of pages	8
Journal	Physiology and Behavior
Volume	191
DOIs	https://doi.org/10.1016/j.physbeh.2018.04.026
Publication status	Published - Jul 1 2018

Bibliographical note

Funding Information:
The HEARTY trial was supported by grant MCT-71979 from the Canadian Institutes of Health Research. Dr. Goldfield was supported by a New Investigator Award from the Canadian Institutes of Health Research for part of this trial and subsequently by an Endowed Research Chair from the Children's Hospital of Eastern Ontario Volunteer Association Board. Dr. Sigal was supported by a Health Senior Scholar award from the Alberta Innovates-Health Solutions and previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. Dr. Kenny was supported by a University Research Chair from the University of Ottawa. Dr. Alberga was supported by a Doctoral Student Research Award from the Canadian Diabetes Association. We would like to thank the HEARTY trial participants, as well as Krista Hind, Bsc (deceased), Bruno Lemire, Ph.D., Marta Wein BSc, Kim Robertson, BSc., Kim Fetch, BSc., Brittany Hanlon, MHA, Jane Yardley, Ph.D., Nadia Balaa, BSc., Karen Lopez, BSc., Pamela Martino, MSc., Kim Morin, BSc., Colleen Gilchrist, BSc., RD., Pascale Messier, BSc., RD., Kelley Phillips, MA, and students in the School of Human Kinetics, University of Ottawa, who contributed to study coordination, exercise training, and evaluation of study participants. Robert Ross, Ph.D. (Queens, University, Kingston, Ontario, Canada), Alison Bradshaw, MSc., and Jennifer Kuk, Ph.D., (York University, Toronto, Ontario, Canada), and Yves Martel, Ph.D., (Tomovision, Magog, Quebec, Canada) assisted with training and provided ongoing advice on body composition analysis. The Ottawa-Carleton Regional YMCA/YWCA (Ottawa, Ontario, Canada), RA Centre (Ottawa, Ontario, Canada), Children's Hospital of Eastern Ontario, and Nautilus Plus and MRI Plus (both in Gatineau, Quebec, Canada) collaborated throughout the trial.

Funding Information:
The HEARTY trial was supported by grant MCT-71979 from the Canadian Institutes of Health Research . Dr. Goldfield was supported by a New Investigator Award from the Canadian Institutes of Health Research for part of this trial and subsequently by an Endowed Research Chair from the Children's Hospital of Eastern Ontario Volunteer Association Board. Dr. Sigal was supported by a Health Senior Scholar award from the Alberta Innovates-Health Solutions and previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. Dr. Kenny was supported by a University Research Chair from the University of Ottawa. Dr. Alberga was supported by a Doctoral Student Research Award from the Canadian Diabetes Association. We would like to thank the HEARTY trial participants, as well as Krista Hind, Bsc (deceased), Bruno Lemire, Ph.D., Marta Wein BSc, Kim Robertson, BSc., Kim Fetch, BSc., Brittany Hanlon, MHA, Jane Yardley, Ph.D., Nadia Balaa, BSc., Karen Lopez, BSc., Pamela Martino, MSc., Kim Morin, BSc., Colleen Gilchrist, BSc., RD., Pascale Messier, BSc., RD., Kelley Phillips, MA, and students in the School of Human Kinetics, University of Ottawa, who contributed to study coordination, exercise training, and evaluation of study participants. Robert Ross, Ph.D. (Queens, University, Kingston, Ontario, Canada), Alison Bradshaw, MSc., and Jennifer Kuk, Ph.D., ( York University , Toronto, Ontario, Canada), and Yves Martel, Ph.D., (Tomovision, Magog, Quebec, Canada) assisted with training and provided ongoing advice on body composition analysis. The Ottawa-Carleton Regional YMCA/YWCA (Ottawa, Ontario, Canada), RA Centre (Ottawa, Ontario, Canada), Children's Hospital of Eastern Ontario, and Nautilus Plus and MRI Plus (both in Gatineau, Quebec, Canada) collaborated throughout the trial.

Publisher Copyright:
© 2018

ASJC Scopus Subject Areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.physbeh.2018.04.026

Cite this

Goldfield, G. S., Kenny, G. P., Prud'homme, D., Holcik, M., Alberga, A. S., Fahnestock, M., Cameron, J. D., Doucette, S., Hadjiyannakis, S., Tulloch, H., Tremblay, M. S., Walsh, J., Guerin, E., Gunnell, K. E., D'Angiulli, A., & Sigal, R. J. (2018). Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity: The hearty randomized controlled trial. Physiology and Behavior, 191, 138-145. https://doi.org/10.1016/j.physbeh.2018.04.026

Goldfield, GS, Kenny, GP, Prud'homme, D, Holcik, M, Alberga, AS, Fahnestock, M, Cameron, JD, Doucette, S, Hadjiyannakis, S, Tulloch, H, Tremblay, MS, Walsh, J, Guerin, E, Gunnell, KE, D'Angiulli, A & Sigal, RJ 2018, 'Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity: The hearty randomized controlled trial', Physiology and Behavior, vol. 191, pp. 138-145. https://doi.org/10.1016/j.physbeh.2018.04.026

@article{f0399a9f3840409ab3079da79ad50161,

title = "Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity: The hearty randomized controlled trial",

abstract = "Brain derived neurotrophic factor (BDNF) is a protein that plays a critical role in modulating cognition in animals and humans. Aerobic exercise often increases BDNF in adults, but effects of this exercise modality and others among adolescents remain uncertain. This study examined the effects of aerobic training, resistance training, and combined training on resting serum BDNF levels in adolescents with overweight and obesity. After a 4-week pre-randomization treatment, 304 post-pubertal, adolescents with overweight or obesity (70% females) aged 14–18 years were randomized to one of four groups for 22 weeks: aerobic training (N = 75), resistance training (N = 78), combined aerobic and resistance training (N = 75), or non-exercising control (N = 76). All participants received dietary counseling targeting a daily energy deficit of 250 kcal. The exercise prescription was 4 times per week, progressing to 45 min/session for the aerobic and resistance groups and 90 min/session for the combined group. Resting serum BDNF levels were measured at baseline and 6-months. Results showed that in both intention-to-treat (ITT) and per protocol (≥70% adherence to prescribed sessions) analyses, there were no significant within- or between-group changes in BDNF. Findings indicate that aerobic training, resistance training or their combination did change serum BDNF levels in adolescents with overweight and obesity. Trial Registration: ClinicalTrials.Gov NCT00195858 http://clinicaltrials.gov/show/NCT00195858, September 12, 2005 (Funded by the Canadian Institutes of Health Research).",

author = "Goldfield, {Gary S.} and Kenny, {Glen P.} and Denis Prud'homme and Martin Holcik and Alberga, {Angela S.} and Margaret Fahnestock and Cameron, {Jameason D.} and Steve Doucette and Stasia Hadjiyannakis and Heather Tulloch and Tremblay, {Mark S.} and Jeremy Walsh and Eva Guerin and Gunnell, {Katie E.} and Amedeo D'Angiulli and Sigal, {Ronald J.}",

note = "Funding Information: The HEARTY trial was supported by grant MCT-71979 from the Canadian Institutes of Health Research. Dr. Goldfield was supported by a New Investigator Award from the Canadian Institutes of Health Research for part of this trial and subsequently by an Endowed Research Chair from the Children's Hospital of Eastern Ontario Volunteer Association Board. Dr. Sigal was supported by a Health Senior Scholar award from the Alberta Innovates-Health Solutions and previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. Dr. Kenny was supported by a University Research Chair from the University of Ottawa. Dr. Alberga was supported by a Doctoral Student Research Award from the Canadian Diabetes Association. We would like to thank the HEARTY trial participants, as well as Krista Hind, Bsc (deceased), Bruno Lemire, Ph.D., Marta Wein BSc, Kim Robertson, BSc., Kim Fetch, BSc., Brittany Hanlon, MHA, Jane Yardley, Ph.D., Nadia Balaa, BSc., Karen Lopez, BSc., Pamela Martino, MSc., Kim Morin, BSc., Colleen Gilchrist, BSc., RD., Pascale Messier, BSc., RD., Kelley Phillips, MA, and students in the School of Human Kinetics, University of Ottawa, who contributed to study coordination, exercise training, and evaluation of study participants. Robert Ross, Ph.D. (Queens, University, Kingston, Ontario, Canada), Alison Bradshaw, MSc., and Jennifer Kuk, Ph.D., (York University, Toronto, Ontario, Canada), and Yves Martel, Ph.D., (Tomovision, Magog, Quebec, Canada) assisted with training and provided ongoing advice on body composition analysis. The Ottawa-Carleton Regional YMCA/YWCA (Ottawa, Ontario, Canada), RA Centre (Ottawa, Ontario, Canada), Children's Hospital of Eastern Ontario, and Nautilus Plus and MRI Plus (both in Gatineau, Quebec, Canada) collaborated throughout the trial. Funding Information: The HEARTY trial was supported by grant MCT-71979 from the Canadian Institutes of Health Research . Dr. Goldfield was supported by a New Investigator Award from the Canadian Institutes of Health Research for part of this trial and subsequently by an Endowed Research Chair from the Children's Hospital of Eastern Ontario Volunteer Association Board. Dr. Sigal was supported by a Health Senior Scholar award from the Alberta Innovates-Health Solutions and previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. Dr. Kenny was supported by a University Research Chair from the University of Ottawa. Dr. Alberga was supported by a Doctoral Student Research Award from the Canadian Diabetes Association. We would like to thank the HEARTY trial participants, as well as Krista Hind, Bsc (deceased), Bruno Lemire, Ph.D., Marta Wein BSc, Kim Robertson, BSc., Kim Fetch, BSc., Brittany Hanlon, MHA, Jane Yardley, Ph.D., Nadia Balaa, BSc., Karen Lopez, BSc., Pamela Martino, MSc., Kim Morin, BSc., Colleen Gilchrist, BSc., RD., Pascale Messier, BSc., RD., Kelley Phillips, MA, and students in the School of Human Kinetics, University of Ottawa, who contributed to study coordination, exercise training, and evaluation of study participants. Robert Ross, Ph.D. (Queens, University, Kingston, Ontario, Canada), Alison Bradshaw, MSc., and Jennifer Kuk, Ph.D., ( York University , Toronto, Ontario, Canada), and Yves Martel, Ph.D., (Tomovision, Magog, Quebec, Canada) assisted with training and provided ongoing advice on body composition analysis. The Ottawa-Carleton Regional YMCA/YWCA (Ottawa, Ontario, Canada), RA Centre (Ottawa, Ontario, Canada), Children's Hospital of Eastern Ontario, and Nautilus Plus and MRI Plus (both in Gatineau, Quebec, Canada) collaborated throughout the trial. Publisher Copyright: {\textcopyright} 2018",

year = "2018",

month = jul,

day = "1",

doi = "10.1016/j.physbeh.2018.04.026",

language = "English",

volume = "191",

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T1 - Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity

T2 - The hearty randomized controlled trial

AU - Goldfield, Gary S.

AU - Kenny, Glen P.

AU - Prud'homme, Denis

AU - Holcik, Martin

AU - Alberga, Angela S.

AU - Fahnestock, Margaret

AU - Cameron, Jameason D.

AU - Doucette, Steve

AU - Hadjiyannakis, Stasia

AU - Tulloch, Heather

AU - Tremblay, Mark S.

AU - Walsh, Jeremy

AU - Guerin, Eva

AU - Gunnell, Katie E.

AU - D'Angiulli, Amedeo

AU - Sigal, Ronald J.

N1 - Funding Information: The HEARTY trial was supported by grant MCT-71979 from the Canadian Institutes of Health Research. Dr. Goldfield was supported by a New Investigator Award from the Canadian Institutes of Health Research for part of this trial and subsequently by an Endowed Research Chair from the Children's Hospital of Eastern Ontario Volunteer Association Board. Dr. Sigal was supported by a Health Senior Scholar award from the Alberta Innovates-Health Solutions and previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. Dr. Kenny was supported by a University Research Chair from the University of Ottawa. Dr. Alberga was supported by a Doctoral Student Research Award from the Canadian Diabetes Association. We would like to thank the HEARTY trial participants, as well as Krista Hind, Bsc (deceased), Bruno Lemire, Ph.D., Marta Wein BSc, Kim Robertson, BSc., Kim Fetch, BSc., Brittany Hanlon, MHA, Jane Yardley, Ph.D., Nadia Balaa, BSc., Karen Lopez, BSc., Pamela Martino, MSc., Kim Morin, BSc., Colleen Gilchrist, BSc., RD., Pascale Messier, BSc., RD., Kelley Phillips, MA, and students in the School of Human Kinetics, University of Ottawa, who contributed to study coordination, exercise training, and evaluation of study participants. Robert Ross, Ph.D. (Queens, University, Kingston, Ontario, Canada), Alison Bradshaw, MSc., and Jennifer Kuk, Ph.D., (York University, Toronto, Ontario, Canada), and Yves Martel, Ph.D., (Tomovision, Magog, Quebec, Canada) assisted with training and provided ongoing advice on body composition analysis. The Ottawa-Carleton Regional YMCA/YWCA (Ottawa, Ontario, Canada), RA Centre (Ottawa, Ontario, Canada), Children's Hospital of Eastern Ontario, and Nautilus Plus and MRI Plus (both in Gatineau, Quebec, Canada) collaborated throughout the trial. Funding Information: The HEARTY trial was supported by grant MCT-71979 from the Canadian Institutes of Health Research . Dr. Goldfield was supported by a New Investigator Award from the Canadian Institutes of Health Research for part of this trial and subsequently by an Endowed Research Chair from the Children's Hospital of Eastern Ontario Volunteer Association Board. Dr. Sigal was supported by a Health Senior Scholar award from the Alberta Innovates-Health Solutions and previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. Dr. Kenny was supported by a University Research Chair from the University of Ottawa. Dr. Alberga was supported by a Doctoral Student Research Award from the Canadian Diabetes Association. We would like to thank the HEARTY trial participants, as well as Krista Hind, Bsc (deceased), Bruno Lemire, Ph.D., Marta Wein BSc, Kim Robertson, BSc., Kim Fetch, BSc., Brittany Hanlon, MHA, Jane Yardley, Ph.D., Nadia Balaa, BSc., Karen Lopez, BSc., Pamela Martino, MSc., Kim Morin, BSc., Colleen Gilchrist, BSc., RD., Pascale Messier, BSc., RD., Kelley Phillips, MA, and students in the School of Human Kinetics, University of Ottawa, who contributed to study coordination, exercise training, and evaluation of study participants. Robert Ross, Ph.D. (Queens, University, Kingston, Ontario, Canada), Alison Bradshaw, MSc., and Jennifer Kuk, Ph.D., ( York University , Toronto, Ontario, Canada), and Yves Martel, Ph.D., (Tomovision, Magog, Quebec, Canada) assisted with training and provided ongoing advice on body composition analysis. The Ottawa-Carleton Regional YMCA/YWCA (Ottawa, Ontario, Canada), RA Centre (Ottawa, Ontario, Canada), Children's Hospital of Eastern Ontario, and Nautilus Plus and MRI Plus (both in Gatineau, Quebec, Canada) collaborated throughout the trial. Publisher Copyright: © 2018

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Brain derived neurotrophic factor (BDNF) is a protein that plays a critical role in modulating cognition in animals and humans. Aerobic exercise often increases BDNF in adults, but effects of this exercise modality and others among adolescents remain uncertain. This study examined the effects of aerobic training, resistance training, and combined training on resting serum BDNF levels in adolescents with overweight and obesity. After a 4-week pre-randomization treatment, 304 post-pubertal, adolescents with overweight or obesity (70% females) aged 14–18 years were randomized to one of four groups for 22 weeks: aerobic training (N = 75), resistance training (N = 78), combined aerobic and resistance training (N = 75), or non-exercising control (N = 76). All participants received dietary counseling targeting a daily energy deficit of 250 kcal. The exercise prescription was 4 times per week, progressing to 45 min/session for the aerobic and resistance groups and 90 min/session for the combined group. Resting serum BDNF levels were measured at baseline and 6-months. Results showed that in both intention-to-treat (ITT) and per protocol (≥70% adherence to prescribed sessions) analyses, there were no significant within- or between-group changes in BDNF. Findings indicate that aerobic training, resistance training or their combination did change serum BDNF levels in adolescents with overweight and obesity. Trial Registration: ClinicalTrials.Gov NCT00195858 http://clinicaltrials.gov/show/NCT00195858, September 12, 2005 (Funded by the Canadian Institutes of Health Research).

AB - Brain derived neurotrophic factor (BDNF) is a protein that plays a critical role in modulating cognition in animals and humans. Aerobic exercise often increases BDNF in adults, but effects of this exercise modality and others among adolescents remain uncertain. This study examined the effects of aerobic training, resistance training, and combined training on resting serum BDNF levels in adolescents with overweight and obesity. After a 4-week pre-randomization treatment, 304 post-pubertal, adolescents with overweight or obesity (70% females) aged 14–18 years were randomized to one of four groups for 22 weeks: aerobic training (N = 75), resistance training (N = 78), combined aerobic and resistance training (N = 75), or non-exercising control (N = 76). All participants received dietary counseling targeting a daily energy deficit of 250 kcal. The exercise prescription was 4 times per week, progressing to 45 min/session for the aerobic and resistance groups and 90 min/session for the combined group. Resting serum BDNF levels were measured at baseline and 6-months. Results showed that in both intention-to-treat (ITT) and per protocol (≥70% adherence to prescribed sessions) analyses, there were no significant within- or between-group changes in BDNF. Findings indicate that aerobic training, resistance training or their combination did change serum BDNF levels in adolescents with overweight and obesity. Trial Registration: ClinicalTrials.Gov NCT00195858 http://clinicaltrials.gov/show/NCT00195858, September 12, 2005 (Funded by the Canadian Institutes of Health Research).

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Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity: The hearty randomized controlled trial

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

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