Abstract
Several investigators have reported the finding of polycystic kidney disease (PKD) at autopsy in patients who had undergone long-term hemodialysis for renal failure due to causes other than PKD. We initiated studies to determine whether the drugs or chemicals to which patients on dialysis are exposed could be responsible for these cystic changes. Adult rats were tube fed chemical residues from an artificial kidney or phthalate esters [di(2-ethylhexyl) phthalate, DEHPJ, which are a main component of these plastic kidneys or a control solution. Rats receiving DEHP or residues showed a significantly higher incidence of focal cysts when compared to controls. Rats receiving DEHP developed a significant decrease in kidney function as demonstrated by creatinine clearance, and these animals had the highest tissue levels of measureable DEHP. We postulate that patients receiving long-term dialysis may acquire PKD secondary to their exposure to chemicals leached from artificial kidneys.
| Original language | English |
|---|---|
| Pages (from-to) | 433-444 |
| Number of pages | 12 |
| Journal | Journal of Toxicology and Environmental Health |
| Volume | 23 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 1988 |
| Externally published | Yes |
Bibliographical note
Funding Information:This work was supported by the Medical Research Council of Canada grant MA7640. P.Acott is a medical student supported by Dalhousie Research Foundation. The authors wish to thank S. McCarthy for her technical assistance, the staff of the Clinical Chemistry Department of the Izaak Walton Killam Hospital for Children, and M. McCuire for typing the manuscript. Requests for reprints should be sent to John F. S. Crocker, Professor, Department of Pediatrics, I.W.K. Hospital for Children, 5850 University Avenue, Halifax, Nova Scotia, Canada B3J 3G9.
ASJC Scopus Subject Areas
- Toxicology
- Pollution
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't