Abstract
Lysosomes, the degradative endpoints and sophisticated cellular signaling hubs, are emerging as intracellular Ca2+ stores that govern multiple cellular processes. Dys-homeostasis of lysosomal Ca2+ is intimately associated with a variety of human diseases including cancer. Recent studies have suggested that the Ca2+-permeable channels Transient Receptor Potential (TRP) Mucolipins (TRPMLs, TRPML1-3) integrate multiple processes of cell growth, division and metabolism. Dysregulation of TRPMLs activity has been implicated in cancer development. In this review, we provide a summary of the latest development of TRPMLs in cancer. The expression of TRPMLs in cancer, TRPMLs in cancer cell nutrient sensing, TRPMLs-mediated lysosomal exocytosis in cancer development, TRPMLs in TFEB-mediated gene transcription of cancer cells, TRPMLs in bacteria-related cancer development and TRPMLs-regulated antitumor immunity are discussed. We hope to guide readers toward a more in-depth discussion of the importance of lysosomal TRPMLs in cancer progression and other human diseases.
| Original language | English |
|---|---|
| Article number | 65 |
| Pages (from-to) | 1-19 |
| Number of pages | 19 |
| Journal | Biomolecules |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2021 |
Bibliographical note
Funding Information:This work was supported by CIHR grant, PJT-156102, to X.-P.D.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
ASJC Scopus Subject Areas
- Biochemistry
- Molecular Biology
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
