Enhanced structure–function relationship in glaucoma with an anatomically and geometrically accurate neuroretinal rim measurement

Vishva M. Danthurebandara; Glen P. Sharpe; Donna M. Hutchison; Jonathan Denniss; Marcelo T. Nicolela; Allison M. McKendrick; Andrew Turpin; Balwantray C. Chauhan

doi:10.1167/iovs.14-15375

Enhanced structure–function relationship in glaucoma with an anatomically and geometrically accurate neuroretinal rim measurement

Vishva M. Danthurebandara, Glen P. Sharpe, Donna M. Hutchison, Jonathan Denniss, Marcelo T. Nicolela, Allison M. McKendrick, Andrew Turpin, Balwantray C. Chauhan

Medicine

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

Purpose: To evaluate the structure–function relationship between disc margin–based rim area (DM-RA) obtained with confocal scanning laser tomography (CSLT), Bruch’s membrane opening–based horizontal rim width (BMO-HRW), minimum rim width (BMO-MRW), peripapillary retinal nerve fiber layer thickness (RNFLT) obtained with spectral-domain optical coherence tomography (SD-OCT), and visual field sensitivity.

Methods: We examined 151 glaucoma patients with CSLT, SD-OCT, and standard automated perimetry on the same day. Optic nerve head (ONH) and RNFL with SD-OCT were acquired relative to a fixed coordinate system (acquired image frame [AIF]) and to the eye-specific fovea-BMO center (FoBMO) axis. Visual field locations were mapped to ONH and RNFL sectors with fixed Garway-Heath (VF_GH) and patient-specific (VF_PS) maps customized for various biometric parameters.

Results: Globally and sectorally, the structure–function relationships between DM-RA and VF_GH, BMO-HRW_AIF and VF_GH, and BMO-HRW_FoBMO and VF_PS were equally weak. The R² for the relationship between DM-RA and VF_GH ranged from 0.1% (inferonasal) to 11% (superotemporal) whereas that between BMO-HRW_AIF and VF_GH ranged from 0.1% (nasal) to 10% (superotemporal). Relatively stronger global and sectoral structure–function relationships with BMO-MRW_AIF and with BMO-MRW_FoBMO were obtained. The R² between BMO-MRW_AIF and VF_GH ranged from 5% (nasal) to 30% (superotemporal), whereas that between BMO-MRW_FoBMO and VF_PS ranged from 5% (nasal) to 25% (inferotemporal). The structure–function relationship with RNFLT was not significantly different from that with BMO-MRW, regardless of image acquisition method.

Conclusions: The structure–function relationship was enhanced with BMO-MRW compared with the other neuroretinal rim measurements, due mainly to its geometrically accurate properties.

Original language	English
Pages (from-to)	98-105
Number of pages	8
Journal	Investigative Ophthalmology and Visual Science
Volume	56
Issue number	1
DOIs	https://doi.org/10.1167/iovs.14-15375
Publication status	Published - Dec 11 2015

Bibliographical note

Publisher Copyright:
© 2015 The Association for Research in Vision and Ophthalmology, Inc.

ASJC Scopus Subject Areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

PubMed: MeSH publication types

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

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10.1167/iovs.14-15375

Cite this

Danthurebandara, V. M., Sharpe, G. P., Hutchison, D. M., Denniss, J., Nicolela, M. T., McKendrick, A. M., Turpin, A., & Chauhan, B. C. (2015). Enhanced structure–function relationship in glaucoma with an anatomically and geometrically accurate neuroretinal rim measurement. Investigative Ophthalmology and Visual Science, 56(1), 98-105. https://doi.org/10.1167/iovs.14-15375

@article{dd935068e2db4eedacf4f907c6240217,

title = "Enhanced structure–function relationship in glaucoma with an anatomically and geometrically accurate neuroretinal rim measurement",

abstract = "Purpose: To evaluate the structure–function relationship between disc margin–based rim area (DM-RA) obtained with confocal scanning laser tomography (CSLT), Bruch{\textquoteright}s membrane opening–based horizontal rim width (BMO-HRW), minimum rim width (BMO-MRW), peripapillary retinal nerve fiber layer thickness (RNFLT) obtained with spectral-domain optical coherence tomography (SD-OCT), and visual field sensitivity.Methods: We examined 151 glaucoma patients with CSLT, SD-OCT, and standard automated perimetry on the same day. Optic nerve head (ONH) and RNFL with SD-OCT were acquired relative to a fixed coordinate system (acquired image frame [AIF]) and to the eye-specific fovea-BMO center (FoBMO) axis. Visual field locations were mapped to ONH and RNFL sectors with fixed Garway-Heath (VFGH) and patient-specific (VFPS) maps customized for various biometric parameters.Results: Globally and sectorally, the structure–function relationships between DM-RA and VFGH, BMO-HRWAIF and VFGH, and BMO-HRWFoBMO and VFPS were equally weak. The R2 for the relationship between DM-RA and VFGH ranged from 0.1% (inferonasal) to 11% (superotemporal) whereas that between BMO-HRWAIF and VFGH ranged from 0.1% (nasal) to 10% (superotemporal). Relatively stronger global and sectoral structure–function relationships with BMO-MRWAIF and with BMO-MRWFoBMO were obtained. The R2 between BMO-MRWAIF and VFGH ranged from 5% (nasal) to 30% (superotemporal), whereas that between BMO-MRWFoBMO and VFPS ranged from 5% (nasal) to 25% (inferotemporal). The structure–function relationship with RNFLT was not significantly different from that with BMO-MRW, regardless of image acquisition method.Conclusions: The structure–function relationship was enhanced with BMO-MRW compared with the other neuroretinal rim measurements, due mainly to its geometrically accurate properties.",

author = "Danthurebandara, {Vishva M.} and Sharpe, {Glen P.} and Hutchison, {Donna M.} and Jonathan Denniss and Nicolela, {Marcelo T.} and McKendrick, {Allison M.} and Andrew Turpin and Chauhan, {Balwantray C.}",

note = "Publisher Copyright: {\textcopyright} 2015 The Association for Research in Vision and Ophthalmology, Inc.",

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doi = "10.1167/iovs.14-15375",

language = "English",

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T1 - Enhanced structure–function relationship in glaucoma with an anatomically and geometrically accurate neuroretinal rim measurement

AU - Danthurebandara, Vishva M.

AU - Sharpe, Glen P.

AU - Hutchison, Donna M.

AU - Denniss, Jonathan

AU - Nicolela, Marcelo T.

AU - McKendrick, Allison M.

AU - Turpin, Andrew

AU - Chauhan, Balwantray C.

PY - 2015/12/11

Y1 - 2015/12/11

N2 - Purpose: To evaluate the structure–function relationship between disc margin–based rim area (DM-RA) obtained with confocal scanning laser tomography (CSLT), Bruch’s membrane opening–based horizontal rim width (BMO-HRW), minimum rim width (BMO-MRW), peripapillary retinal nerve fiber layer thickness (RNFLT) obtained with spectral-domain optical coherence tomography (SD-OCT), and visual field sensitivity.Methods: We examined 151 glaucoma patients with CSLT, SD-OCT, and standard automated perimetry on the same day. Optic nerve head (ONH) and RNFL with SD-OCT were acquired relative to a fixed coordinate system (acquired image frame [AIF]) and to the eye-specific fovea-BMO center (FoBMO) axis. Visual field locations were mapped to ONH and RNFL sectors with fixed Garway-Heath (VFGH) and patient-specific (VFPS) maps customized for various biometric parameters.Results: Globally and sectorally, the structure–function relationships between DM-RA and VFGH, BMO-HRWAIF and VFGH, and BMO-HRWFoBMO and VFPS were equally weak. The R2 for the relationship between DM-RA and VFGH ranged from 0.1% (inferonasal) to 11% (superotemporal) whereas that between BMO-HRWAIF and VFGH ranged from 0.1% (nasal) to 10% (superotemporal). Relatively stronger global and sectoral structure–function relationships with BMO-MRWAIF and with BMO-MRWFoBMO were obtained. The R2 between BMO-MRWAIF and VFGH ranged from 5% (nasal) to 30% (superotemporal), whereas that between BMO-MRWFoBMO and VFPS ranged from 5% (nasal) to 25% (inferotemporal). The structure–function relationship with RNFLT was not significantly different from that with BMO-MRW, regardless of image acquisition method.Conclusions: The structure–function relationship was enhanced with BMO-MRW compared with the other neuroretinal rim measurements, due mainly to its geometrically accurate properties.

AB - Purpose: To evaluate the structure–function relationship between disc margin–based rim area (DM-RA) obtained with confocal scanning laser tomography (CSLT), Bruch’s membrane opening–based horizontal rim width (BMO-HRW), minimum rim width (BMO-MRW), peripapillary retinal nerve fiber layer thickness (RNFLT) obtained with spectral-domain optical coherence tomography (SD-OCT), and visual field sensitivity.Methods: We examined 151 glaucoma patients with CSLT, SD-OCT, and standard automated perimetry on the same day. Optic nerve head (ONH) and RNFL with SD-OCT were acquired relative to a fixed coordinate system (acquired image frame [AIF]) and to the eye-specific fovea-BMO center (FoBMO) axis. Visual field locations were mapped to ONH and RNFL sectors with fixed Garway-Heath (VFGH) and patient-specific (VFPS) maps customized for various biometric parameters.Results: Globally and sectorally, the structure–function relationships between DM-RA and VFGH, BMO-HRWAIF and VFGH, and BMO-HRWFoBMO and VFPS were equally weak. The R2 for the relationship between DM-RA and VFGH ranged from 0.1% (inferonasal) to 11% (superotemporal) whereas that between BMO-HRWAIF and VFGH ranged from 0.1% (nasal) to 10% (superotemporal). Relatively stronger global and sectoral structure–function relationships with BMO-MRWAIF and with BMO-MRWFoBMO were obtained. The R2 between BMO-MRWAIF and VFGH ranged from 5% (nasal) to 30% (superotemporal), whereas that between BMO-MRWFoBMO and VFPS ranged from 5% (nasal) to 25% (inferotemporal). The structure–function relationship with RNFLT was not significantly different from that with BMO-MRW, regardless of image acquisition method.Conclusions: The structure–function relationship was enhanced with BMO-MRW compared with the other neuroretinal rim measurements, due mainly to its geometrically accurate properties.

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Enhanced structure–function relationship in glaucoma with an anatomically and geometrically accurate neuroretinal rim measurement

Abstract

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PubMed: MeSH publication types

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