Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line- derived neurotrophic factor in patients with Parkinson's disease

Ivar Mendez; Alain Dagher; Murray Hong; Adam Hebb; Paula Gaudet; Adam Law; Swarna Weerasinghe; David King; Jacques Desrosiers; Sultan Darvesh; Tanya Acorn; Harold Robertson

doi:10.3171/jns.2000.92.5.0863

Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line- derived neurotrophic factor in patients with Parkinson's disease

Ivar Mendez, Alain Dagher, Murray Hong, Adam Hebb, Paula Gaudet, Adam Law, Swarna Weerasinghe, David King, Jacques Desrosiers, Sultan Darvesh, Tanya Acorn, Harold Robertson

Medicine

Research output: Contribution to journal › Article › peer-review

114 Citations (Scopus)

Abstract

The authors have studied the ability of glial cell line-derived neurotrophic factor (GDNF) to promote survival of human fetal dopaminergic tissue after a storage period of 6 days and subsequent implantation into the human putamen. The results indicate that GDNF promotes survival of stored dopaminergic cells. Cells stored without GDNF had a 30.1% decrease in survival time compared with those exposed to GDNF. Two patients with Parkinson's disease received bilateral putaminal implants of fetal dopaminergic cells exposed to GDNF for 6 days and showed enhancement of graft survival as assessed by positron emission tomography scanning. A mean increase of 107% in putaminal fluorodopa uptake from baseline values was observed 12 months postgrafting.

Original language	English
Pages (from-to)	863-869
Number of pages	7
Journal	Journal of Neurosurgery
Volume	92
Issue number	5
DOIs	https://doi.org/10.3171/jns.2000.92.5.0863
Publication status	Published - May 2000

ASJC Scopus Subject Areas

Surgery
Clinical Neurology

PubMed: MeSH publication types

Comparative Study
Journal Article

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Mendez, I., Dagher, A., Hong, M., Hebb, A., Gaudet, P., Law, A., Weerasinghe, S., King, D., Desrosiers, J., Darvesh, S., Acorn, T., & Robertson, H. (2000). Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line- derived neurotrophic factor in patients with Parkinson's disease. Journal of Neurosurgery, 92(5), 863-869. https://doi.org/10.3171/jns.2000.92.5.0863

Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line- derived neurotrophic factor in patients with Parkinson's disease. / Mendez, Ivar; Dagher, Alain; Hong, Murray et al.
In: Journal of Neurosurgery, Vol. 92, No. 5, 05.2000, p. 863-869.

Research output: Contribution to journal › Article › peer-review

Mendez, I, Dagher, A, Hong, M, Hebb, A, Gaudet, P, Law, A, Weerasinghe, S, King, D, Desrosiers, J, Darvesh, S, Acorn, T & Robertson, H 2000, 'Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line- derived neurotrophic factor in patients with Parkinson's disease', Journal of Neurosurgery, vol. 92, no. 5, pp. 863-869. https://doi.org/10.3171/jns.2000.92.5.0863

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abstract = "The authors have studied the ability of glial cell line-derived neurotrophic factor (GDNF) to promote survival of human fetal dopaminergic tissue after a storage period of 6 days and subsequent implantation into the human putamen. The results indicate that GDNF promotes survival of stored dopaminergic cells. Cells stored without GDNF had a 30.1% decrease in survival time compared with those exposed to GDNF. Two patients with Parkinson's disease received bilateral putaminal implants of fetal dopaminergic cells exposed to GDNF for 6 days and showed enhancement of graft survival as assessed by positron emission tomography scanning. A mean increase of 107% in putaminal fluorodopa uptake from baseline values was observed 12 months postgrafting.",

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Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line- derived neurotrophic factor in patients with Parkinson's disease

Abstract

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

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