Abstract
Type III secretion systems (TTSS) are used by numerous plant and animal pathogens to deliver various effector proteins into host cells. The ability of the pathogen to 'sense' its environment and secrete the appropriate effector molecule(s) seems to be a regulated process. The specialized type III secretion flagellar pathway has distinct classes of genes that are transcriptionally regulated in a hierarchical fashion for the biogenesis of flagella. Many proteins involved in flagellar biogenesis have homologues in the TTSS of pathogens, suggesting that similar regulatory mechanisms exist. Recent studies of the TTSS of pathogens has elucidated roles for transcriptional components, distinct secretion signals and protein interactions that determine the sequential order to the secretion and translocation of effectors involved in virulence.
| Original language | English |
|---|---|
| Pages (from-to) | 398-403 |
| Number of pages | 6 |
| Journal | Trends in Microbiology |
| Volume | 11 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2003 |
| Externally published | Yes |
Bibliographical note
Funding Information:We thank members of the Finlay laboratory for critical reading of the manuscript. We apologize to those whose work is not discussed or cited because of space and reference limitations. Work in our laboratory is supported by operating grants from the Canadian Institute of Health Research (CIHR), the Howard Hughes Medical Institute (HHMI) and the Canadian Bacterial Diseases Network. N.A.T. is the recipient of a Natural Sciences and Engineering Research Council of Canada (NSERC) postdoctoral award and is a Michael Smith Foundation for Health Research (MSFHR) postdoctoral fellow. B.B.F. is a CIHR Distinguished Investigator, a HHMI International Research Scholar and the Peter Wall Distinguished Professor.
ASJC Scopus Subject Areas
- Microbiology
- Microbiology (medical)
- Virology
- Infectious Diseases
