Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial

Holly E.L. Evans; Cynthia C. Forbes; Daniel A. Galvão; Corneel Vandelanotte; Robert U. Newton; Gary Wittert; Suzanne Chambers; Andrew D. Vincent; Ganessan Kichenadasse; Nicholas Brook; Danielle Girard; Camille E. Short

doi:10.1186/s40814-020-00763-2

Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial

Holly E.L. Evans, Cynthia C. Forbes, Daniel A. Galvão, Corneel Vandelanotte, Robert U. Newton, Gary Wittert, Suzanne Chambers, Andrew D. Vincent, Ganessan Kichenadasse, Nicholas Brook, Danielle Girard, Camille E. Short

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Introduction: Preliminary research has shown the effectiveness of supervised exercise-based interventions in alleviating sequela resulting from metastatic prostate cancer. Despite this, many individuals do not engage in sufficient exercise to gain the benefits. There are many barriers, which limit the uptake of face-to-face exercise in this population including lack of suitable facilities, remoteness, and access to experts, significant fatigue, urinary incontinence and motivation. Technology-enabled interventions offer a distance-based alternative. This protocol describes a pilot two-armed randomised controlled study that will investigate the feasibility and preliminary efficacy of an online exercise and behavioural change tool (ExerciseGuide) amongst individuals with metastatic prostate cancer. Methods: Sixty-six participants with histologically diagnosed metastatic prostate cancer will be randomised into either the 8-week intervention or a wait-list control. The intervention arm will have access to a tailored website, remote supervision, and tele-coaching sessions to enhance support and adherence. Algorithms will individually prescribe resistance and aerobic exercise based upon factors such as metastasis location, pain, fatigue, confidence and current exercise levels. Behavioural change strategies and education on exercise benefits, safety and lifestyle are also tailored through the website. The primary outcome will be intervention feasibility (safety, usability, acceptability, and adherence). Secondary exploratory outcomes include changes in physical activity, quality of life, sleep, and physical function. Outcomes will be measured at baseline and week 9. Discussion: The study aims to determine the potential feasibility of an online remotely monitored exercise intervention developed for individuals with metastatic prostate cancer. If feasible, this pilot intervention will inform the design and implementation of further distance-based interventions. Trial registration: ANZCTR, ACTRN12614001268639. Registered 10 December 2018, https://anzctr.org.au/ACTRN12618001979246.aspx

Original language	English
Article number	21
Journal	Pilot and Feasibility Studies
Volume	7
Issue number	1
DOIs	https://doi.org/10.1186/s40814-020-00763-2
Publication status	Published - Dec 2021
Externally published	Yes

Bibliographical note

Funding Information:
This trial is funded by the Australian New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP) through a Below the Belt research grant. HE is funded by a Commonwealth Research Training Programme scholarship and the Freemasons Centre for Men’s Health. CES was supported by a National Health and Medical Research Council ECR Fellowship (ID 1090517) and is currently supported by a Victorian Cancer Agency Mid-Career Fellowship (MCRF19028). The funding bodies had no role in study design, analysis or creation of the manuscript.

Funding Information:
We thank the consumers from the Australian New Zealand Urogenital and Prostate Cancer Trials Group, Freemasons Foundation Centre for Men?s Health and the Peter MacCallum Hospital for their generous input into the web-based tool.

Publisher Copyright:
© 2021, The Author(s).

ASJC Scopus Subject Areas

Medicine (miscellaneous)

PubMed: MeSH publication types

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s40814-020-00763-2

Cite this

Evans, H. E. L., Forbes, C. C., Galvão, D. A., Vandelanotte, C., Newton, R. U., Wittert, G., Chambers, S., Vincent, A. D., Kichenadasse, G., Brook, N., Girard, D., & Short, C. E. (2021). Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial. Pilot and Feasibility Studies, 7(1), Article 21. https://doi.org/10.1186/s40814-020-00763-2

Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial. / Evans, Holly E.L.; Forbes, Cynthia C.; Galvão, Daniel A. et al.
In: Pilot and Feasibility Studies, Vol. 7, No. 1, 21, 12.2021.

Research output: Contribution to journal › Article › peer-review

Evans, HEL, Forbes, CC, Galvão, DA, Vandelanotte, C, Newton, RU, Wittert, G, Chambers, S, Vincent, AD, Kichenadasse, G, Brook, N, Girard, D & Short, CE 2021, 'Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial', Pilot and Feasibility Studies, vol. 7, no. 1, 21. https://doi.org/10.1186/s40814-020-00763-2

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abstract = "Introduction: Preliminary research has shown the effectiveness of supervised exercise-based interventions in alleviating sequela resulting from metastatic prostate cancer. Despite this, many individuals do not engage in sufficient exercise to gain the benefits. There are many barriers, which limit the uptake of face-to-face exercise in this population including lack of suitable facilities, remoteness, and access to experts, significant fatigue, urinary incontinence and motivation. Technology-enabled interventions offer a distance-based alternative. This protocol describes a pilot two-armed randomised controlled study that will investigate the feasibility and preliminary efficacy of an online exercise and behavioural change tool (ExerciseGuide) amongst individuals with metastatic prostate cancer. Methods: Sixty-six participants with histologically diagnosed metastatic prostate cancer will be randomised into either the 8-week intervention or a wait-list control. The intervention arm will have access to a tailored website, remote supervision, and tele-coaching sessions to enhance support and adherence. Algorithms will individually prescribe resistance and aerobic exercise based upon factors such as metastasis location, pain, fatigue, confidence and current exercise levels. Behavioural change strategies and education on exercise benefits, safety and lifestyle are also tailored through the website. The primary outcome will be intervention feasibility (safety, usability, acceptability, and adherence). Secondary exploratory outcomes include changes in physical activity, quality of life, sleep, and physical function. Outcomes will be measured at baseline and week 9. Discussion: The study aims to determine the potential feasibility of an online remotely monitored exercise intervention developed for individuals with metastatic prostate cancer. If feasible, this pilot intervention will inform the design and implementation of further distance-based interventions. Trial registration: ANZCTR, ACTRN12614001268639. Registered 10 December 2018, https://anzctr.org.au/ACTRN12618001979246.aspx",

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note = "Funding Information: This trial is funded by the Australian New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP) through a Below the Belt research grant. HE is funded by a Commonwealth Research Training Programme scholarship and the Freemasons Centre for Men{\textquoteright}s Health. CES was supported by a National Health and Medical Research Council ECR Fellowship (ID 1090517) and is currently supported by a Victorian Cancer Agency Mid-Career Fellowship (MCRF19028). The funding bodies had no role in study design, analysis or creation of the manuscript. Funding Information: We thank the consumers from the Australian New Zealand Urogenital and Prostate Cancer Trials Group, Freemasons Foundation Centre for Men?s Health and the Peter MacCallum Hospital for their generous input into the web-based tool. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

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AU - Galvão, Daniel A.

AU - Vandelanotte, Corneel

AU - Newton, Robert U.

AU - Wittert, Gary

AU - Chambers, Suzanne

AU - Vincent, Andrew D.

AU - Kichenadasse, Ganessan

AU - Brook, Nicholas

AU - Girard, Danielle

AU - Short, Camille E.

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N2 - Introduction: Preliminary research has shown the effectiveness of supervised exercise-based interventions in alleviating sequela resulting from metastatic prostate cancer. Despite this, many individuals do not engage in sufficient exercise to gain the benefits. There are many barriers, which limit the uptake of face-to-face exercise in this population including lack of suitable facilities, remoteness, and access to experts, significant fatigue, urinary incontinence and motivation. Technology-enabled interventions offer a distance-based alternative. This protocol describes a pilot two-armed randomised controlled study that will investigate the feasibility and preliminary efficacy of an online exercise and behavioural change tool (ExerciseGuide) amongst individuals with metastatic prostate cancer. Methods: Sixty-six participants with histologically diagnosed metastatic prostate cancer will be randomised into either the 8-week intervention or a wait-list control. The intervention arm will have access to a tailored website, remote supervision, and tele-coaching sessions to enhance support and adherence. Algorithms will individually prescribe resistance and aerobic exercise based upon factors such as metastasis location, pain, fatigue, confidence and current exercise levels. Behavioural change strategies and education on exercise benefits, safety and lifestyle are also tailored through the website. The primary outcome will be intervention feasibility (safety, usability, acceptability, and adherence). Secondary exploratory outcomes include changes in physical activity, quality of life, sleep, and physical function. Outcomes will be measured at baseline and week 9. Discussion: The study aims to determine the potential feasibility of an online remotely monitored exercise intervention developed for individuals with metastatic prostate cancer. If feasible, this pilot intervention will inform the design and implementation of further distance-based interventions. Trial registration: ANZCTR, ACTRN12614001268639. Registered 10 December 2018, https://anzctr.org.au/ACTRN12618001979246.aspx

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Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

Access to Document

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Cite this