Abstract
Release of endogenous adenosine from rat cortical slices was determined in response to depolarization by 30 mM K+ and by exposure to glutamate. K+ and glutamate both relaease adenosine. Glutamate-evoke release was decreased by approximately 50% in the presence of the N-methyl-d-asparatate (NMDA) receptor antagonists, 2-amino-5-phosphonovaleric acid (APV). The adenosine released by glutamate could modulate neurotransmission, and may have a protective effect in pathologic conditions of excess excitation involving glutamate.
| Original language | English |
|---|---|
| Pages (from-to) | 149-151 |
| Number of pages | 3 |
| Journal | Brain Research |
| Volume | 478 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 23 1989 |
Bibliographical note
Funding Information:K.H. is a fellow of the Medical Research Council of Canada. This study was supported by funds from the Medical Research Council of Canada in a grant to T.D.W.
ASJC Scopus Subject Areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't