Sanderson, H., Gray, K. L., Manuele, A., Maguire, F., Khan, A., Liu, C., Navanekere Rudrappa, C., Nash, J. H. E., Robertson, J., Bessonov, K., Oloni, M., Alcock, B. P., Raphenya, A. R., McAllister, T. A., Peacock, S. J., Raven, K. E., Gouliouris, T., McArthur, A. G., Brinkman, F. S. L., ... Beiko, R. G. (2022). Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents. Microbial genomics, 8(9). https://doi.org/10.1099/mgen.0.000880
Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents. / Sanderson, Haley; Gray, Kristen L.; Manuele, Alexander et al.
In:
Microbial genomics, Vol. 8, No. 9, 01.09.2022.
Research output: Contribution to journal › Article › peer-review
Sanderson, H, Gray, KL, Manuele, A, Maguire, F, Khan, A, Liu, C, Navanekere Rudrappa, C, Nash, JHE, Robertson, J, Bessonov, K, Oloni, M, Alcock, BP, Raphenya, AR, McAllister, TA, Peacock, SJ, Raven, KE, Gouliouris, T, McArthur, AG, Brinkman, FSL, Fink, RC, Zaheer, R & Beiko, RG 2022, 'Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents', Microbial genomics, vol. 8, no. 9. https://doi.org/10.1099/mgen.0.000880
Sanderson H, Gray KL, Manuele A, Maguire F, Khan A, Liu C et al. Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents. Microbial genomics. 2022 Sept 1;8(9). doi: 10.1099/mgen.0.000880
Sanderson, Haley ; Gray, Kristen L. ; Manuele, Alexander et al. / Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents. In: Microbial genomics. 2022 ; Vol. 8, No. 9.
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title = "Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents",
abstract = "Enterococcus faecium is a ubiquitous opportunistic pathogen that is exhibiting increasing levels of antimicrobial resistance (AMR). Many of the genes that confer resistance and pathogenic functions are localized on mobile genetic elements (MGEs), which facilitate their transfer between lineages. Here, features including resistance determinants, virulence factors and MGEs were profiled in a set of 1273 E. faecium genomes from two disparate geographic locations (in the UK and Canada) from a range of agricultural, clinical and associated habitats. Neither lineages of E. faecium, type A and B, nor MGEs are constrained by geographic proximity, but our results show evidence of a strong association of many profiled genes and MGEs with habitat. Many features were associated with a group of clinical and municipal wastewater genomes that are likely forming a new human-associated ecotype within type A. The evolutionary dynamics of E. faecium make it a highly versatile emerging pathogen, and its ability to acquire, transmit and lose features presents a high risk for the emergence of new pathogenic variants and novel resistance combinations. This study provides a workflow for MGE-centric surveillance of AMR in Enterococcus that can be adapted to other pathogens.",
author = "Haley Sanderson and Gray, {Kristen L.} and Alexander Manuele and Finlay Maguire and Amjad Khan and Chaoyue Liu and {Navanekere Rudrappa}, Chandana and Nash, {John H.E.} and James Robertson and Kyrylo Bessonov and Martins Oloni and Alcock, {Brian P.} and Raphenya, {Amogelang R.} and McAllister, {Tim A.} and Peacock, {Sharon J.} and Raven, {Kathy E.} and Theodore Gouliouris and McArthur, {Andrew G.} and Brinkman, {Fiona S.L.} and Fink, {Ryan C.} and Rahat Zaheer and Beiko, {Robert G.}",
year = "2022",
month = sep,
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doi = "10.1099/mgen.0.000880",
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AU - Sanderson, Haley
AU - Gray, Kristen L.
AU - Manuele, Alexander
AU - Maguire, Finlay
AU - Khan, Amjad
AU - Liu, Chaoyue
AU - Navanekere Rudrappa, Chandana
AU - Nash, John H.E.
AU - Robertson, James
AU - Bessonov, Kyrylo
AU - Oloni, Martins
AU - Alcock, Brian P.
AU - Raphenya, Amogelang R.
AU - McAllister, Tim A.
AU - Peacock, Sharon J.
AU - Raven, Kathy E.
AU - Gouliouris, Theodore
AU - McArthur, Andrew G.
AU - Brinkman, Fiona S.L.
AU - Fink, Ryan C.
AU - Zaheer, Rahat
AU - Beiko, Robert G.
PY - 2022/9/1
Y1 - 2022/9/1
N2 - Enterococcus faecium is a ubiquitous opportunistic pathogen that is exhibiting increasing levels of antimicrobial resistance (AMR). Many of the genes that confer resistance and pathogenic functions are localized on mobile genetic elements (MGEs), which facilitate their transfer between lineages. Here, features including resistance determinants, virulence factors and MGEs were profiled in a set of 1273 E. faecium genomes from two disparate geographic locations (in the UK and Canada) from a range of agricultural, clinical and associated habitats. Neither lineages of E. faecium, type A and B, nor MGEs are constrained by geographic proximity, but our results show evidence of a strong association of many profiled genes and MGEs with habitat. Many features were associated with a group of clinical and municipal wastewater genomes that are likely forming a new human-associated ecotype within type A. The evolutionary dynamics of E. faecium make it a highly versatile emerging pathogen, and its ability to acquire, transmit and lose features presents a high risk for the emergence of new pathogenic variants and novel resistance combinations. This study provides a workflow for MGE-centric surveillance of AMR in Enterococcus that can be adapted to other pathogens.
AB - Enterococcus faecium is a ubiquitous opportunistic pathogen that is exhibiting increasing levels of antimicrobial resistance (AMR). Many of the genes that confer resistance and pathogenic functions are localized on mobile genetic elements (MGEs), which facilitate their transfer between lineages. Here, features including resistance determinants, virulence factors and MGEs were profiled in a set of 1273 E. faecium genomes from two disparate geographic locations (in the UK and Canada) from a range of agricultural, clinical and associated habitats. Neither lineages of E. faecium, type A and B, nor MGEs are constrained by geographic proximity, but our results show evidence of a strong association of many profiled genes and MGEs with habitat. Many features were associated with a group of clinical and municipal wastewater genomes that are likely forming a new human-associated ecotype within type A. The evolutionary dynamics of E. faecium make it a highly versatile emerging pathogen, and its ability to acquire, transmit and lose features presents a high risk for the emergence of new pathogenic variants and novel resistance combinations. This study provides a workflow for MGE-centric surveillance of AMR in Enterococcus that can be adapted to other pathogens.
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