TY - JOUR
T1 - Extracorporeal photopheresis for the treatment of Crohn's disease
AU - Fowler, Sharyle
AU - Jones, Jennifer
AU - Hull, Peter R.
AU - Ghosh, Subrata
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Small, open-label studies show promising results for ECP in the treatment of steroid-dependent and medically-refractory Crohn's disease. However, proper randomized, sham-controlled trials have not yet been performed. Based on the proposed mechanism of action of ECP, induction of a tolerogenic T cell response, ECP should be assessed in patients with early inflammatory disease rather than those who have progressed to fibrotic or stricturing disease. Randomized, sham-controlled trials need to be performed before ECP can be incorporated into standard clinical practice for the treatment of Crohn's disease.
AB - Small, open-label studies show promising results for ECP in the treatment of steroid-dependent and medically-refractory Crohn's disease. However, proper randomized, sham-controlled trials have not yet been performed. Based on the proposed mechanism of action of ECP, induction of a tolerogenic T cell response, ECP should be assessed in patients with early inflammatory disease rather than those who have progressed to fibrotic or stricturing disease. Randomized, sham-controlled trials need to be performed before ECP can be incorporated into standard clinical practice for the treatment of Crohn's disease.
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U2 - 10.1016/j.transci.2015.02.006
DO - 10.1016/j.transci.2015.02.006
M3 - Review article
C2 - 25747960
AN - SCOPUS:84930479831
SN - 1473-0502
VL - 52
SP - 183
EP - 186
JO - Transfusion and Apheresis Science
JF - Transfusion and Apheresis Science
IS - 2
ER -