FOS and FOSB expression in the medial preoptic nucleus pars compacta of maternally active C57BL/6J and DBA/2J mice

W. B. Mathieson; Michael Wilkinson; Richard E. Brown; Tamara L.Y. Bond; Sean W. Taylor; Paul E. Neumann

doi:10.1016/S0006-8993(02)03078-0

FOS and FOSB expression in the medial preoptic nucleus pars compacta of maternally active C57BL/6J and DBA/2J mice

W. B. Mathieson, Michael Wilkinson, Richard E. Brown, Tamara L.Y. Bond, Sean W. Taylor, Paul E. Neumann

Medicine

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

C57BL/6J and DBA/2J inbred mice differ in aspects of maternal behavior and in the morphology of the medial preoptic nucleus (MPO), suggesting a possible association. DBA/2J mice have a compact subnucleus in the MPO, the MPOpc, that is sexually dimorphic and absent in C57BL/6J mice. To determine whether MPOpc cells are activated by maternal behavior, FOS and FOSB immunohistochemistry was performed on brain sections of C57BL/6J and DBA/2J mothers following the return of their pups after a separation of 2 days. In both light and dark phases of the daily cycle, stimulation of DBA/2J mothers evoked an increase in FOS- and FOSB-immunoreactivity in the MPOpc. Stimulated C57BL/6J mice, which lack the MPOpc, did not show an increase in cellular activity in the corresponding MPO region. Cells immediately lateral to the MPOpc were activated by pup stimulation, in both strains. These results suggest that MPOpc cells are active during maternal behavior, and that strain differences in maternal behavior are related to anatomical differences in the MPO.

Original language	English
Pages (from-to)	170-175
Number of pages	6
Journal	Brain Research
Volume	952
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(02)03078-0
Publication status	Published - Oct 18 2002

Bibliographical note

Funding Information:
This research was supported by CIHR grant MT-15507 to P.E.N. We thank Diane Wilkinson and Christianne Hawken for technical assistance.

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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Mathieson, W. B., Wilkinson, M., Brown, R. E., Bond, T. L. Y., Taylor, S. W., & Neumann, P. E. (2002). FOS and FOSB expression in the medial preoptic nucleus pars compacta of maternally active C57BL/6J and DBA/2J mice. Brain Research, 952(2), 170-175. https://doi.org/10.1016/S0006-8993(02)03078-0

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title = "FOS and FOSB expression in the medial preoptic nucleus pars compacta of maternally active C57BL/6J and DBA/2J mice",

abstract = "C57BL/6J and DBA/2J inbred mice differ in aspects of maternal behavior and in the morphology of the medial preoptic nucleus (MPO), suggesting a possible association. DBA/2J mice have a compact subnucleus in the MPO, the MPOpc, that is sexually dimorphic and absent in C57BL/6J mice. To determine whether MPOpc cells are activated by maternal behavior, FOS and FOSB immunohistochemistry was performed on brain sections of C57BL/6J and DBA/2J mothers following the return of their pups after a separation of 2 days. In both light and dark phases of the daily cycle, stimulation of DBA/2J mothers evoked an increase in FOS- and FOSB-immunoreactivity in the MPOpc. Stimulated C57BL/6J mice, which lack the MPOpc, did not show an increase in cellular activity in the corresponding MPO region. Cells immediately lateral to the MPOpc were activated by pup stimulation, in both strains. These results suggest that MPOpc cells are active during maternal behavior, and that strain differences in maternal behavior are related to anatomical differences in the MPO.",

author = "Mathieson, {W. B.} and Michael Wilkinson and Brown, {Richard E.} and Bond, {Tamara L.Y.} and Taylor, {Sean W.} and Neumann, {Paul E.}",

note = "Funding Information: This research was supported by CIHR grant MT-15507 to P.E.N. We thank Diane Wilkinson and Christianne Hawken for technical assistance.",

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doi = "10.1016/S0006-8993(02)03078-0",

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AU - Brown, Richard E.

AU - Bond, Tamara L.Y.

AU - Taylor, Sean W.

AU - Neumann, Paul E.

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PY - 2002/10/18

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N2 - C57BL/6J and DBA/2J inbred mice differ in aspects of maternal behavior and in the morphology of the medial preoptic nucleus (MPO), suggesting a possible association. DBA/2J mice have a compact subnucleus in the MPO, the MPOpc, that is sexually dimorphic and absent in C57BL/6J mice. To determine whether MPOpc cells are activated by maternal behavior, FOS and FOSB immunohistochemistry was performed on brain sections of C57BL/6J and DBA/2J mothers following the return of their pups after a separation of 2 days. In both light and dark phases of the daily cycle, stimulation of DBA/2J mothers evoked an increase in FOS- and FOSB-immunoreactivity in the MPOpc. Stimulated C57BL/6J mice, which lack the MPOpc, did not show an increase in cellular activity in the corresponding MPO region. Cells immediately lateral to the MPOpc were activated by pup stimulation, in both strains. These results suggest that MPOpc cells are active during maternal behavior, and that strain differences in maternal behavior are related to anatomical differences in the MPO.

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FOS and FOSB expression in the medial preoptic nucleus pars compacta of maternally active C57BL/6J and DBA/2J mice

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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