FRAIL scale: Predictive validity and diagnostic test accuracy

Mark Q. Thompson; Olga Theou; Graeme R. Tucker; Robert J. Adams; Renuka Visvanathan

doi:10.1111/ajag.12829

FRAIL scale: Predictive validity and diagnostic test accuracy

Mark Q. Thompson, Olga Theou, Graeme R. Tucker, Robert J. Adams, Renuka Visvanathan

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Objective: To examine the predictive validity of the FRAIL scale for mortality, and diagnostic test accuracy (DTA) against the frailty phenotype (FP). Measurement: Frailty was measured in 846 community-dwelling adults (mean age 74.3[SD 6.3] years, 54.8% female) using a modified FRAIL scale and modified FP. Mortality was matched to death records. Results: The FRAIL scale demonstrated significant predictive validity for mortality up to 10 years (Frail adjHR: 2.60, P <.001). DTA findings were acceptable for specificity (86.8%) and Youden index (0.50), but not sensitivity (63.6%), or area under the receiver operator curve (auROC) (0.75). DTA estimates were more acceptable when a cut-point of ≥2 characteristics was used rather than ≥3 in the primary DTA analysis. Conclusion: The FRAIL scale is a valid predictor of mortality. DTA estimates depend on FRAIL scale cut-point used. This instrument is a potentially useful frailty screening tool.

Original language	English
Pages (from-to)	e529-e536
Journal	Australasian Journal on Ageing
Volume	39
Issue number	4
DOIs	https://doi.org/10.1111/ajag.12829
Publication status	Published - Dec 2020

Bibliographical note

Funding Information:
The authors would like to acknowledge the contribution of the North West Adelaide Health Study participants and clinic staff. This work was supported by the Resthaven GTRAC Research Grant to OT.

Publisher Copyright:
© 2020 AJA Inc.

ASJC Scopus Subject Areas

Community and Home Care
Geriatrics and Gerontology

PubMed: MeSH publication types

Journal Article

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abstract = "Objective: To examine the predictive validity of the FRAIL scale for mortality, and diagnostic test accuracy (DTA) against the frailty phenotype (FP). Measurement: Frailty was measured in 846 community-dwelling adults (mean age 74.3[SD 6.3] years, 54.8% female) using a modified FRAIL scale and modified FP. Mortality was matched to death records. Results: The FRAIL scale demonstrated significant predictive validity for mortality up to 10 years (Frail adjHR: 2.60, P <.001). DTA findings were acceptable for specificity (86.8%) and Youden index (0.50), but not sensitivity (63.6%), or area under the receiver operator curve (auROC) (0.75). DTA estimates were more acceptable when a cut-point of ≥2 characteristics was used rather than ≥3 in the primary DTA analysis. Conclusion: The FRAIL scale is a valid predictor of mortality. DTA estimates depend on FRAIL scale cut-point used. This instrument is a potentially useful frailty screening tool.",

author = "Thompson, {Mark Q.} and Olga Theou and Tucker, {Graeme R.} and Adams, {Robert J.} and Renuka Visvanathan",

note = "Funding Information: The authors would like to acknowledge the contribution of the North West Adelaide Health Study participants and clinic staff. This work was supported by the Resthaven GTRAC Research Grant to OT. Publisher Copyright: {\textcopyright} 2020 AJA Inc.",

year = "2020",

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AU - Theou, Olga

AU - Tucker, Graeme R.

AU - Adams, Robert J.

AU - Visvanathan, Renuka

N1 - Funding Information: The authors would like to acknowledge the contribution of the North West Adelaide Health Study participants and clinic staff. This work was supported by the Resthaven GTRAC Research Grant to OT. Publisher Copyright: © 2020 AJA Inc.

PY - 2020/12

Y1 - 2020/12

N2 - Objective: To examine the predictive validity of the FRAIL scale for mortality, and diagnostic test accuracy (DTA) against the frailty phenotype (FP). Measurement: Frailty was measured in 846 community-dwelling adults (mean age 74.3[SD 6.3] years, 54.8% female) using a modified FRAIL scale and modified FP. Mortality was matched to death records. Results: The FRAIL scale demonstrated significant predictive validity for mortality up to 10 years (Frail adjHR: 2.60, P <.001). DTA findings were acceptable for specificity (86.8%) and Youden index (0.50), but not sensitivity (63.6%), or area under the receiver operator curve (auROC) (0.75). DTA estimates were more acceptable when a cut-point of ≥2 characteristics was used rather than ≥3 in the primary DTA analysis. Conclusion: The FRAIL scale is a valid predictor of mortality. DTA estimates depend on FRAIL scale cut-point used. This instrument is a potentially useful frailty screening tool.

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FRAIL scale: Predictive validity and diagnostic test accuracy

Abstract

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