Abstract
The increasing life spans of people infected with human immunodeficiency virus (HIV) reflect enormous treatment successes and present new challenges related to aging. Even with suppression of viral loads and immune reconstitution, HIV-positive individuals exhibit excess vulnerability to multiple health problems that are not AIDS-defining. With the accumulation of multiple health problems, it is likely that many people aging with treated HIV infection may be identified as frail. Studies of frailty in people with HIV are currently limited but suggest that frailty might be feasible and useful as an integrative marker of multisystem vulnerability, for organizing care and for comprehensively measuring the impact of illness and treatment on overall health status. This review explains how frailty has been conceptualized and measured in the general population, critically reviews emerging data on frailty in people with HIV infection, and explores how the concept of frailty might inform HIV research and care.
Original language | English |
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Pages (from-to) | 1170-1179 |
Number of pages | 10 |
Journal | Journal of Infectious Diseases |
Volume | 210 |
Issue number | 8 |
DOIs | |
Publication status | Published - Oct 15 2014 |
Bibliographical note
Publisher Copyright:© The Author 2014.
ASJC Scopus Subject Areas
- Immunology and Allergy
- Infectious Diseases
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't