Genetic analysis of cerebellar folial pattern in crosses of C57BL/6J and DBA/2J inbred mice

Paul E. Neumann; John D. Garretson; George P. Skabardonis; Gary G. Mueller

doi:10.1016/0006-8993(93)91598-M

Genetic analysis of cerebellar folial pattern in crosses of C57BL/6J and DBA/2J inbred mice

Paul E. Neumann, John D. Garretson, George P. Skabardonis, Gary G. Mueller

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Variation in the cerebellar folial pattern of mice is influenced by genetic elements [Inouye, M. and Oda, S., J. Comp. Neurol., 190 (1980) 357-362]. In crosses of C57BL/6J and DBA/2J inbred mice, the presence or absence of a specific fissure, the intraculminate fissure, is largely determined by a single genetic locus (Cfp-1), which is located on distal Chromosome 4 [Neumann et al., Brain Res., 524 (1990) 85-89]. In the present study, the mid-sagittal cerebellar folial pattern has been examined in crosses of C57BL/6J and DBA/2J mice and in BXD recombinant inbred strains. At least three loci, including Cfp-1, are involved in variation in vermian pattern formation. Genetic variation in thyroid hormone function may be involved in the inheritance of folial pattern. A locus (Cfp-2) that appears to be partially responsible for this negative genetic correlation in mice may be linked to Afp on Chromosome 5. This hypothesis was suggested by the negative correlation between neonatal serum T₄ level and the number of folia in rats given neonatal injections of thyroxine or propylthiouracil [Lauder, J.M. et al., Brain Res., 76 (1974) 33-40].

Original language	English
Pages (from-to)	81-88
Number of pages	8
Journal	Brain Research
Volume	619
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(93)91598-M
Publication status	Published - Aug 13 1993
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgements. This manuscript is dedicated to Dr. Charles Barlow on the occasion of his retirement from the Bronson Crothers Professorship (Harvard Medical School) for his support of this project. The authors thank Dr. Wim E. Crusio for providing a traditional quantitative genetic analysis of the classical cross data and Drs. Donald Bailey, Larry Benowitz, Merton Bernfield, Robert Collins, Wim Crnsio, Scott Pomeroy, Lydia Villa-Komaroff and Lewis Wolpert for critical readings of various drafts of the manuscript. The work was supported in part by Children's Hospital and the Public Health Service (N01-HD-02912, P30-HD18655, P30-HD-27805 and UO1-HD-28882). Children's Hospital is fully accredited by the American Association for Accreditation of Laboratory Animal Care.

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(93)91598-M

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title = "Genetic analysis of cerebellar folial pattern in crosses of C57BL/6J and DBA/2J inbred mice",

abstract = "Variation in the cerebellar folial pattern of mice is influenced by genetic elements [Inouye, M. and Oda, S., J. Comp. Neurol., 190 (1980) 357-362]. In crosses of C57BL/6J and DBA/2J inbred mice, the presence or absence of a specific fissure, the intraculminate fissure, is largely determined by a single genetic locus (Cfp-1), which is located on distal Chromosome 4 [Neumann et al., Brain Res., 524 (1990) 85-89]. In the present study, the mid-sagittal cerebellar folial pattern has been examined in crosses of C57BL/6J and DBA/2J mice and in BXD recombinant inbred strains. At least three loci, including Cfp-1, are involved in variation in vermian pattern formation. Genetic variation in thyroid hormone function may be involved in the inheritance of folial pattern. A locus (Cfp-2) that appears to be partially responsible for this negative genetic correlation in mice may be linked to Afp on Chromosome 5. This hypothesis was suggested by the negative correlation between neonatal serum T4 level and the number of folia in rats given neonatal injections of thyroxine or propylthiouracil [Lauder, J.M. et al., Brain Res., 76 (1974) 33-40].",

author = "Neumann, {Paul E.} and Garretson, {John D.} and Skabardonis, {George P.} and Mueller, {Gary G.}",

note = "Funding Information: Acknowledgements. This manuscript is dedicated to Dr. Charles Barlow on the occasion of his retirement from the Bronson Crothers Professorship (Harvard Medical School) for his support of this project. The authors thank Dr. Wim E. Crusio for providing a traditional quantitative genetic analysis of the classical cross data and Drs. Donald Bailey, Larry Benowitz, Merton Bernfield, Robert Collins, Wim Crnsio, Scott Pomeroy, Lydia Villa-Komaroff and Lewis Wolpert for critical readings of various drafts of the manuscript. The work was supported in part by Children's Hospital and the Public Health Service (N01-HD-02912, P30-HD18655, P30-HD-27805 and UO1-HD-28882). Children's Hospital is fully accredited by the American Association for Accreditation of Laboratory Animal Care.",

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AU - Skabardonis, George P.

AU - Mueller, Gary G.

N1 - Funding Information: Acknowledgements. This manuscript is dedicated to Dr. Charles Barlow on the occasion of his retirement from the Bronson Crothers Professorship (Harvard Medical School) for his support of this project. The authors thank Dr. Wim E. Crusio for providing a traditional quantitative genetic analysis of the classical cross data and Drs. Donald Bailey, Larry Benowitz, Merton Bernfield, Robert Collins, Wim Crnsio, Scott Pomeroy, Lydia Villa-Komaroff and Lewis Wolpert for critical readings of various drafts of the manuscript. The work was supported in part by Children's Hospital and the Public Health Service (N01-HD-02912, P30-HD18655, P30-HD-27805 and UO1-HD-28882). Children's Hospital is fully accredited by the American Association for Accreditation of Laboratory Animal Care.

PY - 1993/8/13

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N2 - Variation in the cerebellar folial pattern of mice is influenced by genetic elements [Inouye, M. and Oda, S., J. Comp. Neurol., 190 (1980) 357-362]. In crosses of C57BL/6J and DBA/2J inbred mice, the presence or absence of a specific fissure, the intraculminate fissure, is largely determined by a single genetic locus (Cfp-1), which is located on distal Chromosome 4 [Neumann et al., Brain Res., 524 (1990) 85-89]. In the present study, the mid-sagittal cerebellar folial pattern has been examined in crosses of C57BL/6J and DBA/2J mice and in BXD recombinant inbred strains. At least three loci, including Cfp-1, are involved in variation in vermian pattern formation. Genetic variation in thyroid hormone function may be involved in the inheritance of folial pattern. A locus (Cfp-2) that appears to be partially responsible for this negative genetic correlation in mice may be linked to Afp on Chromosome 5. This hypothesis was suggested by the negative correlation between neonatal serum T4 level and the number of folia in rats given neonatal injections of thyroxine or propylthiouracil [Lauder, J.M. et al., Brain Res., 76 (1974) 33-40].

AB - Variation in the cerebellar folial pattern of mice is influenced by genetic elements [Inouye, M. and Oda, S., J. Comp. Neurol., 190 (1980) 357-362]. In crosses of C57BL/6J and DBA/2J inbred mice, the presence or absence of a specific fissure, the intraculminate fissure, is largely determined by a single genetic locus (Cfp-1), which is located on distal Chromosome 4 [Neumann et al., Brain Res., 524 (1990) 85-89]. In the present study, the mid-sagittal cerebellar folial pattern has been examined in crosses of C57BL/6J and DBA/2J mice and in BXD recombinant inbred strains. At least three loci, including Cfp-1, are involved in variation in vermian pattern formation. Genetic variation in thyroid hormone function may be involved in the inheritance of folial pattern. A locus (Cfp-2) that appears to be partially responsible for this negative genetic correlation in mice may be linked to Afp on Chromosome 5. This hypothesis was suggested by the negative correlation between neonatal serum T4 level and the number of folia in rats given neonatal injections of thyroxine or propylthiouracil [Lauder, J.M. et al., Brain Res., 76 (1974) 33-40].

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Genetic analysis of cerebellar folial pattern in crosses of C57BL/6J and DBA/2J inbred mice

Abstract

Bibliographical note

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