Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

Xiangdong Liu; Pietro Invernizzi; Yue Lu; Roman Kosoy; Yan Lu; Ilaria Bianchi; Mauro Podda; Chun Xu; Gang Xie; Fabio MacCiardi; Carlo Selmi; Sara Lupoli; Russell Shigeta; Michael Ransom; Ana Lleo; Annette T. Lee; Andrew L. Mason; Robert P. Myers; Kevork M. Peltekian; Cameron N. Ghent; Francesca Bernuzzi; Massimo Zuin; Floriano Rosina; Elisabetta Borghesio; Annarosa Floreani; Roberta Lazzari; Grazia Niro; Angelo Andriulli; Luigi Muratori; Paolo Muratori; Piero L. Almasio; Pietro Andreone; Marzia Margotti; Maurizia Brunetto; Barbara Coco; Domenico Alvaro; Maria C. Bragazzi; Fabio Marra; Alessandro Pisano; Cristina Rigamonti; Massimo Colombo; Marco Marzioni; Antonio Benedetti; Luca Fabris; Mario Strazzabosco; Piero Portincasa; Vincenzo O. Palmieri; Claudio Tiribelli; Lory Croce; Savino Bruno; Sonia Rossi; Maria Vinci; Cleofe Prisco; Alberto Mattalia; Pierluigi Toniutto; Antonio Picciotto; Andrea Galli; Carlo Ferrari; Silvia Colombo; Giovanni Casella; Lorenzo Morini; Nicola Caporaso; Agostino Colli; Giancarlo Spinzi; Renzo Montanari; Peter K. Gregersen; E. Jenny Heathcote; Gideon M. Hirschfield; Katherine A. Siminovitch; Christopher I. Amos; M. Eric Gershwin; Michael F. Seldin

doi:10.1038/ng.627

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

Xiangdong Liu, Pietro Invernizzi, Yue Lu, Roman Kosoy, Yan Lu, Ilaria Bianchi, Mauro Podda, Chun Xu, Gang Xie, Fabio MacCiardi, Carlo Selmi, Sara Lupoli, Russell Shigeta, Michael Ransom, Ana Lleo, Annette T. Lee, Andrew L. Mason, Robert P. Myers, Kevork M. Peltekian, Cameron N. GhentFrancesca Bernuzzi, Massimo Zuin, Floriano Rosina, Elisabetta Borghesio, Annarosa Floreani, Roberta Lazzari, Grazia Niro, Angelo Andriulli, Luigi Muratori, Paolo Muratori, Piero L. Almasio, Pietro Andreone, Marzia Margotti, Maurizia Brunetto, Barbara Coco, Domenico Alvaro, Maria C. Bragazzi, Fabio Marra, Alessandro Pisano, Cristina Rigamonti, Massimo Colombo, Marco Marzioni, Antonio Benedetti, Luca Fabris, Mario Strazzabosco, Piero Portincasa, Vincenzo O. Palmieri, Claudio Tiribelli, Lory Croce, Savino Bruno, Sonia Rossi, Maria Vinci, Cleofe Prisco, Alberto Mattalia, Pierluigi Toniutto, Antonio Picciotto, Andrea Galli, Carlo Ferrari, Silvia Colombo, Giovanni Casella, Lorenzo Morini, Nicola Caporaso, Agostino Colli, Giancarlo Spinzi, Renzo Montanari, Peter K. Gregersen, E. Jenny Heathcote, Gideon M. Hirschfield, Katherine A. Siminovitch, Christopher I. Amos, M. Eric Gershwin, Michael F. Seldin

Medicine

Research output: Contribution to journal › Article › peer-review

362 Citations (Scopus)

Abstract

A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10^-11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10 ^-10, OR = 1.63) and 17q12-21 (P = 1.7 × 10^-10, OR = 1.38).

Original language	English
Pages (from-to)	658-660
Number of pages	3
Journal	Nature Genetics
Volume	42
Issue number	8
DOIs	https://doi.org/10.1038/ng.627
Publication status	Published - Aug 2010

Bibliographical note

Funding Information:
We thank the subjects and physicians who contributed DNA samples and clinical data for this study. This work was supported in part by the US National Institutes of Health (R01 DK056839, R01 DK80670, K23 DK68290 and RO3 DK78527), the Canadian Institutes for Health Research (MOP 74621), the Ontario Research Fund (RE01-061), the Canadian Primary Biliary Cirrhosis Society, the American Gastroenterological Association and the A.J. and Sigismunda Palumbo Charitable Trust.

ASJC Scopus Subject Areas

Genetics

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Liu, X., Invernizzi, P., Lu, Y., Kosoy, R., Lu, Y., Bianchi, I., Podda, M., Xu, C., Xie, G., MacCiardi, F., Selmi, C., Lupoli, S., Shigeta, R., Ransom, M., Lleo, A., Lee, A. T., Mason, A. L., Myers, R. P., Peltekian, K. M., ... Seldin, M. F. (2010). Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Nature Genetics, 42(8), 658-660. https://doi.org/10.1038/ng.627

Liu, X, Invernizzi, P, Lu, Y, Kosoy, R, Lu, Y, Bianchi, I, Podda, M, Xu, C, Xie, G, MacCiardi, F, Selmi, C, Lupoli, S, Shigeta, R, Ransom, M, Lleo, A, Lee, AT, Mason, AL, Myers, RP, Peltekian, KM, Ghent, CN, Bernuzzi, F, Zuin, M, Rosina, F, Borghesio, E, Floreani, A, Lazzari, R, Niro, G, Andriulli, A, Muratori, L, Muratori, P, Almasio, PL, Andreone, P, Margotti, M, Brunetto, M, Coco, B, Alvaro, D, Bragazzi, MC, Marra, F, Pisano, A, Rigamonti, C, Colombo, M, Marzioni, M, Benedetti, A, Fabris, L, Strazzabosco, M, Portincasa, P, Palmieri, VO, Tiribelli, C, Croce, L, Bruno, S, Rossi, S, Vinci, M, Prisco, C, Mattalia, A, Toniutto, P, Picciotto, A, Galli, A, Ferrari, C, Colombo, S, Casella, G, Morini, L, Caporaso, N, Colli, A, Spinzi, G, Montanari, R, Gregersen, PK, Heathcote, EJ, Hirschfield, GM, Siminovitch, KA, Amos, CI, Gershwin, ME & Seldin, MF 2010, 'Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis', Nature Genetics, vol. 42, no. 8, pp. 658-660. https://doi.org/10.1038/ng.627

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title = "Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis",

abstract = "A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10-11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10 -10, OR = 1.63) and 17q12-21 (P = 1.7 × 10-10, OR = 1.38).",

author = "Xiangdong Liu and Pietro Invernizzi and Yue Lu and Roman Kosoy and Yan Lu and Ilaria Bianchi and Mauro Podda and Chun Xu and Gang Xie and Fabio MacCiardi and Carlo Selmi and Sara Lupoli and Russell Shigeta and Michael Ransom and Ana Lleo and Lee, {Annette T.} and Mason, {Andrew L.} and Myers, {Robert P.} and Peltekian, {Kevork M.} and Ghent, {Cameron N.} and Francesca Bernuzzi and Massimo Zuin and Floriano Rosina and Elisabetta Borghesio and Annarosa Floreani and Roberta Lazzari and Grazia Niro and Angelo Andriulli and Luigi Muratori and Paolo Muratori and Almasio, {Piero L.} and Pietro Andreone and Marzia Margotti and Maurizia Brunetto and Barbara Coco and Domenico Alvaro and Bragazzi, {Maria C.} and Fabio Marra and Alessandro Pisano and Cristina Rigamonti and Massimo Colombo and Marco Marzioni and Antonio Benedetti and Luca Fabris and Mario Strazzabosco and Piero Portincasa and Palmieri, {Vincenzo O.} and Claudio Tiribelli and Lory Croce and Savino Bruno and Sonia Rossi and Maria Vinci and Cleofe Prisco and Alberto Mattalia and Pierluigi Toniutto and Antonio Picciotto and Andrea Galli and Carlo Ferrari and Silvia Colombo and Giovanni Casella and Lorenzo Morini and Nicola Caporaso and Agostino Colli and Giancarlo Spinzi and Renzo Montanari and Gregersen, {Peter K.} and Heathcote, {E. Jenny} and Hirschfield, {Gideon M.} and Siminovitch, {Katherine A.} and Amos, {Christopher I.} and Gershwin, {M. Eric} and Seldin, {Michael F.}",

note = "Funding Information: We thank the subjects and physicians who contributed DNA samples and clinical data for this study. This work was supported in part by the US National Institutes of Health (R01 DK056839, R01 DK80670, K23 DK68290 and RO3 DK78527), the Canadian Institutes for Health Research (MOP 74621), the Ontario Research Fund (RE01-061), the Canadian Primary Biliary Cirrhosis Society, the American Gastroenterological Association and the A.J. and Sigismunda Palumbo Charitable Trust.",

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doi = "10.1038/ng.627",

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AU - Liu, Xiangdong

AU - Invernizzi, Pietro

AU - Lu, Yue

AU - Kosoy, Roman

AU - Lu, Yan

AU - Bianchi, Ilaria

AU - Podda, Mauro

AU - Xu, Chun

AU - Xie, Gang

AU - MacCiardi, Fabio

AU - Selmi, Carlo

AU - Lupoli, Sara

AU - Shigeta, Russell

AU - Ransom, Michael

AU - Lleo, Ana

AU - Lee, Annette T.

AU - Mason, Andrew L.

AU - Myers, Robert P.

AU - Peltekian, Kevork M.

AU - Ghent, Cameron N.

AU - Bernuzzi, Francesca

AU - Zuin, Massimo

AU - Rosina, Floriano

AU - Borghesio, Elisabetta

AU - Floreani, Annarosa

AU - Lazzari, Roberta

AU - Niro, Grazia

AU - Andriulli, Angelo

AU - Muratori, Luigi

AU - Muratori, Paolo

AU - Almasio, Piero L.

AU - Andreone, Pietro

AU - Margotti, Marzia

AU - Brunetto, Maurizia

AU - Coco, Barbara

AU - Alvaro, Domenico

AU - Bragazzi, Maria C.

AU - Marra, Fabio

AU - Pisano, Alessandro

AU - Rigamonti, Cristina

AU - Colombo, Massimo

AU - Marzioni, Marco

AU - Benedetti, Antonio

AU - Fabris, Luca

AU - Strazzabosco, Mario

AU - Portincasa, Piero

AU - Palmieri, Vincenzo O.

AU - Tiribelli, Claudio

AU - Croce, Lory

AU - Bruno, Savino

AU - Rossi, Sonia

AU - Vinci, Maria

AU - Prisco, Cleofe

AU - Mattalia, Alberto

AU - Toniutto, Pierluigi

AU - Picciotto, Antonio

AU - Galli, Andrea

AU - Ferrari, Carlo

AU - Colombo, Silvia

AU - Casella, Giovanni

AU - Morini, Lorenzo

AU - Caporaso, Nicola

AU - Colli, Agostino

AU - Spinzi, Giancarlo

AU - Montanari, Renzo

AU - Gregersen, Peter K.

AU - Heathcote, E. Jenny

AU - Hirschfield, Gideon M.

AU - Siminovitch, Katherine A.

AU - Amos, Christopher I.

AU - Gershwin, M. Eric

AU - Seldin, Michael F.

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Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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