Glucocorticoid teratogenesis in the developing nephron

J. F.S. Crocker, M. R. Ogborn

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Although the induction of polycystic kidney disease by neonatal glucocorticoid treatment has been extensively documented, there are no data on induction of polycystic kidney disease with fetal exposure to glucocorticoids. We injected groups of pregnant Swiss Webster albino mice subcutaneously with 250 mg/kg of hydrocortisone acetate on individual days from days 1 to 19 of gestation. A control group received an equal volume of saline. Histologic analysis of 1,522 kidneys from the offspring of these animals revealed no evidence of polycystic kidneys in the control group or in offspring of animals injected before day 11 of pregnancy. A bimodal distribution of cystic kidney disease was noted in the remaining animals, with highest prevalence after injection on day 12 (50.8%) and day 17 (34.3%). We conclude that 250 mg/kg of glucocorticoids may induce polycystic kidney disease in utero, but possibly only during critical periods of metanephric development.

Original languageEnglish
Pages (from-to)571-574
Number of pages4
JournalTeratology
Volume43
Issue number6
DOIs
Publication statusPublished - Jun 1991

ASJC Scopus Subject Areas

  • Embryology
  • Toxicology
  • Developmental Biology
  • Health, Toxicology and Mutagenesis

Fingerprint

Dive into the research topics of 'Glucocorticoid teratogenesis in the developing nephron'. Together they form a unique fingerprint.

Cite this

Crocker, J. F. S., & Ogborn, M. R. (1991). Glucocorticoid teratogenesis in the developing nephron. Teratology, 43(6), 571-574. https://doi.org/10.1002/tera.1420430611