Hygromycin B therapy of a murine coronaviral hepatitis

G. Macintyre; B. Curry; F. Wong; R. Anderson

doi:10.1128/AAC.35.10.2125

Hygromycin B therapy of a murine coronaviral hepatitis

G. Macintyre, B. Curry, F. Wong, R. Anderson

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Hepatitis caused by mouse hepatitis virus (MHV-A59), a murine coronavirus, is accompanied by direct infection and replication of virus within the liver. We demonstrate here that the aminoglycoside hygromycin B is able to eliminate MHV-A59 infection from mouse peritoneal macrophages and cultured liver cells in vitro and is also able to reduce levels of virus replication and necrotic liver foci in vivo.

Original language	English
Pages (from-to)	2125-2127
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	35
Issue number	10
DOIs	https://doi.org/10.1128/AAC.35.10.2125
Publication status	Published - 1991
Externally published	Yes

ASJC Scopus Subject Areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.35.10.2125

Cite this

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title = "Hygromycin B therapy of a murine coronaviral hepatitis",

abstract = "Hepatitis caused by mouse hepatitis virus (MHV-A59), a murine coronavirus, is accompanied by direct infection and replication of virus within the liver. We demonstrate here that the aminoglycoside hygromycin B is able to eliminate MHV-A59 infection from mouse peritoneal macrophages and cultured liver cells in vitro and is also able to reduce levels of virus replication and necrotic liver foci in vivo.",

author = "G. Macintyre and B. Curry and F. Wong and R. Anderson",

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doi = "10.1128/AAC.35.10.2125",

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T1 - Hygromycin B therapy of a murine coronaviral hepatitis

AU - Macintyre, G.

AU - Curry, B.

AU - Wong, F.

AU - Anderson, R.

PY - 1991

Y1 - 1991

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AB - Hepatitis caused by mouse hepatitis virus (MHV-A59), a murine coronavirus, is accompanied by direct infection and replication of virus within the liver. We demonstrate here that the aminoglycoside hygromycin B is able to eliminate MHV-A59 infection from mouse peritoneal macrophages and cultured liver cells in vitro and is also able to reduce levels of virus replication and necrotic liver foci in vivo.

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M3 - Article

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ER -

Hygromycin B therapy of a murine coronaviral hepatitis

Abstract

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

Access to Document

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