Immune thrombocytopenia following successful treatment of cancer in children

Victoria Price; Chris Barnes; Patricia Canning; Victor Blanchette; Mark Greenberg

doi:10.1002/pbc.20341

Immune thrombocytopenia following successful treatment of cancer in children

Victoria Price, Chris Barnes, Patricia Canning, Victor Blanchette, Mark Greenberg

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A predisposition to developing immune thrombocytopenia (ITP) has not been reported in survivors of childhood cancer. We report a case series of childhood cancer survivors who developed an isolated thrombocytopenia in the presence of a normocellular bone marrow. Five children, two with endodermal sinus tumors and three with acute lymphoblastic leukemia, developed ITP at a median of 4 years (range: 0.2-8 years) after completion of therapy. We suggest the association of ITP in survivors of childhood malignancy may not be co-incidental as chemotherapy may cause persistent immune dysfunction.

Original language	English
Pages (from-to)	372-376
Number of pages	5
Journal	Pediatric Blood and Cancer
Volume	46
Issue number	3
DOIs	https://doi.org/10.1002/pbc.20341
Publication status	Published - Mar 2006
Externally published	Yes

ASJC Scopus Subject Areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

PubMed: MeSH publication types

Case Reports
Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/pbc.20341

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title = "Immune thrombocytopenia following successful treatment of cancer in children",

abstract = "A predisposition to developing immune thrombocytopenia (ITP) has not been reported in survivors of childhood cancer. We report a case series of childhood cancer survivors who developed an isolated thrombocytopenia in the presence of a normocellular bone marrow. Five children, two with endodermal sinus tumors and three with acute lymphoblastic leukemia, developed ITP at a median of 4 years (range: 0.2-8 years) after completion of therapy. We suggest the association of ITP in survivors of childhood malignancy may not be co-incidental as chemotherapy may cause persistent immune dysfunction.",

author = "Victoria Price and Chris Barnes and Patricia Canning and Victor Blanchette and Mark Greenberg",

year = "2006",

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journal = "Pediatric Blood and Cancer",

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T1 - Immune thrombocytopenia following successful treatment of cancer in children

AU - Price, Victoria

AU - Barnes, Chris

AU - Canning, Patricia

AU - Blanchette, Victor

AU - Greenberg, Mark

PY - 2006/3

Y1 - 2006/3

N2 - A predisposition to developing immune thrombocytopenia (ITP) has not been reported in survivors of childhood cancer. We report a case series of childhood cancer survivors who developed an isolated thrombocytopenia in the presence of a normocellular bone marrow. Five children, two with endodermal sinus tumors and three with acute lymphoblastic leukemia, developed ITP at a median of 4 years (range: 0.2-8 years) after completion of therapy. We suggest the association of ITP in survivors of childhood malignancy may not be co-incidental as chemotherapy may cause persistent immune dysfunction.

AB - A predisposition to developing immune thrombocytopenia (ITP) has not been reported in survivors of childhood cancer. We report a case series of childhood cancer survivors who developed an isolated thrombocytopenia in the presence of a normocellular bone marrow. Five children, two with endodermal sinus tumors and three with acute lymphoblastic leukemia, developed ITP at a median of 4 years (range: 0.2-8 years) after completion of therapy. We suggest the association of ITP in survivors of childhood malignancy may not be co-incidental as chemotherapy may cause persistent immune dysfunction.

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SP - 372

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JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 3

ER -

Immune thrombocytopenia following successful treatment of cancer in children

Abstract

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

Access to Document

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