Immunity toward H1N1 influenza hemagglutinin of historical and contemporary strains suggests protection and vaccine failure

Stephen S.H. Huang; Zhen Lin; David Banner; Alberto J. León; Stéphane G. Paquette; Barry Rubin; Salvatore Rubino; Yi Guan; David J. Kelvin; Alyson A. Kelvin

doi:10.1038/srep01698

Immunity toward H1N1 influenza hemagglutinin of historical and contemporary strains suggests protection and vaccine failure

Stephen S.H. Huang, Zhen Lin, David Banner, Alberto J. León, Stéphane G. Paquette, Barry Rubin, Salvatore Rubino, Yi Guan, David J. Kelvin, Alyson A. Kelvin

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21 Citations (Scopus)

Abstract

Evolution of H1N1 influenza A outbreaks of the past 100 years is interesting and significantly complex and details of H1N1 genetic drift remains unknown. Here we investigated the clinical characteristics and immune cross-reactivity of significant historical H1N1 strains. We infected ferrets with H1N1 strains from 1943, 1947, 1977, 1986, 1999, and 2009 and showed each produced a unique clinical signature. We found significant cross-reactivity between viruses with similar HA sequences. Interestingly, A/FortMonmouth/1/1947 antisera cross-reacted with A/USSR/90/1977 virus, thought to be a 1947 resurfaced virus. Importantly, our immunological data that didn't show cross-reactivity can be extrapolated to failure of past H1N1 influenza vaccines, ie. 1947, 1986 and 2009. Together, our results help to elucidate H1N1 immuno-genetic alterations that occurred in the past 100 years and immune responses caused by H1N1 evolution. This work will facilitate development of future influenza therapeutics and prophylactics such as influenza vaccines.

Original language	English
Article number	1698
Journal	Scientific Reports
Volume	3
DOIs	https://doi.org/10.1038/srep01698
Publication status	Published - 2013
Externally published	Yes

Bibliographical note

Funding Information:
All influenza strains, A/PuertoRico/8/1934, A/AA/Marton/43, A/FortMonmouth/1/1947, A/USSR/90/1977, A/Taiwan/1/1986, A/NewCaledonia/20/1999, A/SolomonIslands/3/ 2006, A/Brisbane/59/2007 and A/NewYork/18/2009 were obtained through the Influenza Reagent Resource, Influenza Division, WHO Collaborating Center for Surveillance, Epidemiology and Control of Influenza, Centers for Disease Control and Prevention, Atlanta, GA, USA. We thank the Li Ka-Shing Foundation of Canada, Immune Diagnostics & Research, and Shantou University Medical College for the support of conducting this study. A/Mexico/4108/2009 virus was obtained through the Influenza Reagent Resource, Influenza Division, WHO Collaborating Center for Surveillance, Epidemiology and Control of Influenza, Centers for Disease Control and Prevention, Atlanta, GA, USA.

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General

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/srep01698

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@article{eaa0166c08b54d42977ec28b7b042a00,

title = "Immunity toward H1N1 influenza hemagglutinin of historical and contemporary strains suggests protection and vaccine failure",

abstract = "Evolution of H1N1 influenza A outbreaks of the past 100 years is interesting and significantly complex and details of H1N1 genetic drift remains unknown. Here we investigated the clinical characteristics and immune cross-reactivity of significant historical H1N1 strains. We infected ferrets with H1N1 strains from 1943, 1947, 1977, 1986, 1999, and 2009 and showed each produced a unique clinical signature. We found significant cross-reactivity between viruses with similar HA sequences. Interestingly, A/FortMonmouth/1/1947 antisera cross-reacted with A/USSR/90/1977 virus, thought to be a 1947 resurfaced virus. Importantly, our immunological data that didn't show cross-reactivity can be extrapolated to failure of past H1N1 influenza vaccines, ie. 1947, 1986 and 2009. Together, our results help to elucidate H1N1 immuno-genetic alterations that occurred in the past 100 years and immune responses caused by H1N1 evolution. This work will facilitate development of future influenza therapeutics and prophylactics such as influenza vaccines.",

author = "Huang, {Stephen S.H.} and Zhen Lin and David Banner and Le{\'o}n, {Alberto J.} and Paquette, {St{\'e}phane G.} and Barry Rubin and Salvatore Rubino and Yi Guan and Kelvin, {David J.} and Kelvin, {Alyson A.}",

note = "Funding Information: All influenza strains, A/PuertoRico/8/1934, A/AA/Marton/43, A/FortMonmouth/1/1947, A/USSR/90/1977, A/Taiwan/1/1986, A/NewCaledonia/20/1999, A/SolomonIslands/3/ 2006, A/Brisbane/59/2007 and A/NewYork/18/2009 were obtained through the Influenza Reagent Resource, Influenza Division, WHO Collaborating Center for Surveillance, Epidemiology and Control of Influenza, Centers for Disease Control and Prevention, Atlanta, GA, USA. We thank the Li Ka-Shing Foundation of Canada, Immune Diagnostics & Research, and Shantou University Medical College for the support of conducting this study. A/Mexico/4108/2009 virus was obtained through the Influenza Reagent Resource, Influenza Division, WHO Collaborating Center for Surveillance, Epidemiology and Control of Influenza, Centers for Disease Control and Prevention, Atlanta, GA, USA.",

year = "2013",

doi = "10.1038/srep01698",

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AU - Huang, Stephen S.H.

AU - Lin, Zhen

AU - Banner, David

AU - León, Alberto J.

AU - Paquette, Stéphane G.

AU - Rubin, Barry

AU - Rubino, Salvatore

AU - Guan, Yi

AU - Kelvin, David J.

AU - Kelvin, Alyson A.

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PY - 2013

Y1 - 2013

N2 - Evolution of H1N1 influenza A outbreaks of the past 100 years is interesting and significantly complex and details of H1N1 genetic drift remains unknown. Here we investigated the clinical characteristics and immune cross-reactivity of significant historical H1N1 strains. We infected ferrets with H1N1 strains from 1943, 1947, 1977, 1986, 1999, and 2009 and showed each produced a unique clinical signature. We found significant cross-reactivity between viruses with similar HA sequences. Interestingly, A/FortMonmouth/1/1947 antisera cross-reacted with A/USSR/90/1977 virus, thought to be a 1947 resurfaced virus. Importantly, our immunological data that didn't show cross-reactivity can be extrapolated to failure of past H1N1 influenza vaccines, ie. 1947, 1986 and 2009. Together, our results help to elucidate H1N1 immuno-genetic alterations that occurred in the past 100 years and immune responses caused by H1N1 evolution. This work will facilitate development of future influenza therapeutics and prophylactics such as influenza vaccines.

AB - Evolution of H1N1 influenza A outbreaks of the past 100 years is interesting and significantly complex and details of H1N1 genetic drift remains unknown. Here we investigated the clinical characteristics and immune cross-reactivity of significant historical H1N1 strains. We infected ferrets with H1N1 strains from 1943, 1947, 1977, 1986, 1999, and 2009 and showed each produced a unique clinical signature. We found significant cross-reactivity between viruses with similar HA sequences. Interestingly, A/FortMonmouth/1/1947 antisera cross-reacted with A/USSR/90/1977 virus, thought to be a 1947 resurfaced virus. Importantly, our immunological data that didn't show cross-reactivity can be extrapolated to failure of past H1N1 influenza vaccines, ie. 1947, 1986 and 2009. Together, our results help to elucidate H1N1 immuno-genetic alterations that occurred in the past 100 years and immune responses caused by H1N1 evolution. This work will facilitate development of future influenza therapeutics and prophylactics such as influenza vaccines.

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Immunity toward H1N1 influenza hemagglutinin of historical and contemporary strains suggests protection and vaccine failure

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

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