Immunomodulating principles from shark cartilage: Part 1. Isolation and biological assessment in vitro

J. A. Kralovec, Y. Guan, K. Metera, R. I. Carr

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Extracts from shark cartilage exhibiting powerful immunostimulating activity in vitro are described. The study shows that a simple extraction with water is very effective in producing the immunostimulating principles and implies that it is ideal for scale-up and manufacturing on a large scale. The extracts are potent stimulators of B cells and macrophages isolated from BALB/c mice spleen while stimulation of T cells was insignificant in our in vitro models. The study demonstrates that the active principles are thermally stable proteoglycans with molecular masses exceeding 100 kDa. This in vitro study represents an important step needed for further assessment of the products in vivo and their value for nutraceutical use.

Original languageEnglish
Pages (from-to)657-669
Number of pages13
JournalInternational Immunopharmacology
Volume3
Issue number5
DOIs
Publication statusPublished - May 2003

Bibliographical note

Funding Information:
This study was supported in part by the IRAP program of the National Research Council of Canada.

ASJC Scopus Subject Areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Fingerprint

Dive into the research topics of 'Immunomodulating principles from shark cartilage: Part 1. Isolation and biological assessment in vitro'. Together they form a unique fingerprint.

Cite this