Impact of age and sex on the relationship between carotid intima-media thickness and frailty level in the Canadian Longitudinal Study of Aging

Myles W. O'Brien; Derek S. Kimmerly; Olga Theou

doi:10.1016/j.jjcc.2023.01.004

Impact of age and sex on the relationship between carotid intima-media thickness and frailty level in the Canadian Longitudinal Study of Aging

Myles W. O'Brien, Derek S. Kimmerly, Olga Theou

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Background: Carotid intima-media thickness (cIMT) provides an index of arterial injury. Frailty is an indicator of vulnerability to adverse health outcomes. It is unclear whether cIMT is associated with the multi-dimensional frailty index and/or if this relationship is age- or sex-specific. The aim was to determine the impact of age and sex on the relationship between cIMT and frailty level in middle-aged and older adults. Methods: Frailty and cIMT data were extracted from the Canadian Longitudinal Study of Aging baseline comprehensive cohort of middle-aged (45–64 years) and older adults (>65 years) (n = 10,209). cIMT was assessed via high-resolution ultrasound. Frailty was determined using a 52-item index. Covariate-adjusted ordinary least squares regressions were conducted separately for middle-aged males (n = 3178), middle-aged females (n = 3125), older males (n = 2031), and older females (n = 1875). Results: Average cIMTs were larger in older versus middle-aged adults and in males versus females (all, p < 0.001). Average cIMT was positively associated with frailty level in adjusted linear regression models in middle-aged males [adj. R² = 0.09; β = 0.015 (95 % CI: 0.005–0.026), p = 0.004], middle-aged females [adj. R² = 0.11; β = 0.040 (95 % CI: 0.025–0.054), p < 0.001], older males [adj. R² = 0.12; β = 0.019 (95 % CI: 0.004–0.034), p = 0.01], and older females [adj. R² = 0.11; β = 0.020 (95 % CI: 0.002–0.039), p = 0.03]. Conclusion: cIMT was an independent contributor to frailty level regardless of age group (middle-aged/older adults) or sex, with the strongest effect observed in middle-aged females. Our cross-sectional study documents the independent relationship between a marker of cardiovascular function and an increased vulnerability to adverse health outcomes in middle-aged and older males and females.

Original language	English
Journal	Journal of Cardiology
DOIs	https://doi.org/10.1016/j.jjcc.2023.01.004
Publication status	Accepted/In press - 2023

Bibliographical note

Funding Information:
MWO was supported by a CIHR Post-Doctoral Fellowship Award (#181747) and a Dalhousie University Department of Medicine University Internal Medicine Research Foundation Research Fellowship Award. This research was made possible using the data/biospecimens collected by the Canadian Longitudinal Study on Aging (CLSA). Funding for the Canadian Longitudinal Study on Aging (CLSA) is provided by the Government of Canada through the Canadian Institutes of Health Research (CIHR) under grant reference: LSA 94473 and the Canada Foundation for Innovation as well as the following provinces, Newfoundland, Nova Scotia, Quebec, Ontario, Manitoba, Alberta, and British Columbia. This research has been conducted using the CLSA dataset Baseline Comprehensive V5.1, under Application Number 1906015. The CLSA is led by Drs Parminder Raina, Christina Wolfson, and Susan Kirkland. The opinions expressed in this manuscript are the authors' own and do not reflect the views of the Canadian Longitudinal Study on Aging.

Funding Information:
MWO was supported by a CIHR Post-Doctoral Fellowship Award (#181747) and a Dalhousie University Department of Medicine University Internal Medicine Research Foundation Research Fellowship Award.

Funding Information:
This research was made possible using the data/biospecimens collected by the Canadian Longitudinal Study on Aging (CLSA). Funding for the Canadian Longitudinal Study on Aging (CLSA) is provided by the Government of Canada through the Canadian Institutes of Health Research (CIHR) under grant reference: LSA 94473 and the Canada Foundation for Innovation as well as the following provinces, Newfoundland, Nova Scotia, Quebec, Ontario, Manitoba, Alberta, and British Columbia. This research has been conducted using the CLSA dataset Baseline Comprehensive V5.1, under Application Number 1906015. The CLSA is led by Drs Parminder Raina, Christina Wolfson, and Susan Kirkland. The opinions expressed in this manuscript are the authors' own and do not reflect the views of the Canadian Longitudinal Study on Aging.

Publisher Copyright:
© 2023 Elsevier Ltd

ASJC Scopus Subject Areas

Cardiology and Cardiovascular Medicine

PubMed: MeSH publication types

Journal Article

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10.1016/j.jjcc.2023.01.004

Cite this

@article{25941534469741d8932e1ffcef2ba597,

title = "Impact of age and sex on the relationship between carotid intima-media thickness and frailty level in the Canadian Longitudinal Study of Aging",

abstract = "Background: Carotid intima-media thickness (cIMT) provides an index of arterial injury. Frailty is an indicator of vulnerability to adverse health outcomes. It is unclear whether cIMT is associated with the multi-dimensional frailty index and/or if this relationship is age- or sex-specific. The aim was to determine the impact of age and sex on the relationship between cIMT and frailty level in middle-aged and older adults. Methods: Frailty and cIMT data were extracted from the Canadian Longitudinal Study of Aging baseline comprehensive cohort of middle-aged (45–64 years) and older adults (>65 years) (n = 10,209). cIMT was assessed via high-resolution ultrasound. Frailty was determined using a 52-item index. Covariate-adjusted ordinary least squares regressions were conducted separately for middle-aged males (n = 3178), middle-aged females (n = 3125), older males (n = 2031), and older females (n = 1875). Results: Average cIMTs were larger in older versus middle-aged adults and in males versus females (all, p < 0.001). Average cIMT was positively associated with frailty level in adjusted linear regression models in middle-aged males [adj. R2 = 0.09; β = 0.015 (95 % CI: 0.005–0.026), p = 0.004], middle-aged females [adj. R2 = 0.11; β = 0.040 (95 % CI: 0.025–0.054), p < 0.001], older males [adj. R2 = 0.12; β = 0.019 (95 % CI: 0.004–0.034), p = 0.01], and older females [adj. R2 = 0.11; β = 0.020 (95 % CI: 0.002–0.039), p = 0.03]. Conclusion: cIMT was an independent contributor to frailty level regardless of age group (middle-aged/older adults) or sex, with the strongest effect observed in middle-aged females. Our cross-sectional study documents the independent relationship between a marker of cardiovascular function and an increased vulnerability to adverse health outcomes in middle-aged and older males and females.",

author = "O'Brien, {Myles W.} and Kimmerly, {Derek S.} and Olga Theou",

note = "Funding Information: MWO was supported by a CIHR Post-Doctoral Fellowship Award (#181747) and a Dalhousie University Department of Medicine University Internal Medicine Research Foundation Research Fellowship Award. This research was made possible using the data/biospecimens collected by the Canadian Longitudinal Study on Aging (CLSA). Funding for the Canadian Longitudinal Study on Aging (CLSA) is provided by the Government of Canada through the Canadian Institutes of Health Research (CIHR) under grant reference: LSA 94473 and the Canada Foundation for Innovation as well as the following provinces, Newfoundland, Nova Scotia, Quebec, Ontario, Manitoba, Alberta, and British Columbia. This research has been conducted using the CLSA dataset Baseline Comprehensive V5.1, under Application Number 1906015. The CLSA is led by Drs Parminder Raina, Christina Wolfson, and Susan Kirkland. The opinions expressed in this manuscript are the authors' own and do not reflect the views of the Canadian Longitudinal Study on Aging. Funding Information: MWO was supported by a CIHR Post-Doctoral Fellowship Award (#181747) and a Dalhousie University Department of Medicine University Internal Medicine Research Foundation Research Fellowship Award. Funding Information: This research was made possible using the data/biospecimens collected by the Canadian Longitudinal Study on Aging (CLSA). Funding for the Canadian Longitudinal Study on Aging (CLSA) is provided by the Government of Canada through the Canadian Institutes of Health Research (CIHR) under grant reference: LSA 94473 and the Canada Foundation for Innovation as well as the following provinces, Newfoundland, Nova Scotia, Quebec, Ontario, Manitoba, Alberta, and British Columbia. This research has been conducted using the CLSA dataset Baseline Comprehensive V5.1, under Application Number 1906015. The CLSA is led by Drs Parminder Raina, Christina Wolfson, and Susan Kirkland. The opinions expressed in this manuscript are the authors' own and do not reflect the views of the Canadian Longitudinal Study on Aging. Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

doi = "10.1016/j.jjcc.2023.01.004",

language = "English",

journal = "Journal of Cardiology",

issn = "0914-5087",

publisher = "Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai)",

}

TY - JOUR

T1 - Impact of age and sex on the relationship between carotid intima-media thickness and frailty level in the Canadian Longitudinal Study of Aging

AU - O'Brien, Myles W.

AU - Kimmerly, Derek S.

AU - Theou, Olga

N1 - Funding Information: MWO was supported by a CIHR Post-Doctoral Fellowship Award (#181747) and a Dalhousie University Department of Medicine University Internal Medicine Research Foundation Research Fellowship Award. This research was made possible using the data/biospecimens collected by the Canadian Longitudinal Study on Aging (CLSA). Funding for the Canadian Longitudinal Study on Aging (CLSA) is provided by the Government of Canada through the Canadian Institutes of Health Research (CIHR) under grant reference: LSA 94473 and the Canada Foundation for Innovation as well as the following provinces, Newfoundland, Nova Scotia, Quebec, Ontario, Manitoba, Alberta, and British Columbia. This research has been conducted using the CLSA dataset Baseline Comprehensive V5.1, under Application Number 1906015. The CLSA is led by Drs Parminder Raina, Christina Wolfson, and Susan Kirkland. The opinions expressed in this manuscript are the authors' own and do not reflect the views of the Canadian Longitudinal Study on Aging. Funding Information: MWO was supported by a CIHR Post-Doctoral Fellowship Award (#181747) and a Dalhousie University Department of Medicine University Internal Medicine Research Foundation Research Fellowship Award. Funding Information: This research was made possible using the data/biospecimens collected by the Canadian Longitudinal Study on Aging (CLSA). Funding for the Canadian Longitudinal Study on Aging (CLSA) is provided by the Government of Canada through the Canadian Institutes of Health Research (CIHR) under grant reference: LSA 94473 and the Canada Foundation for Innovation as well as the following provinces, Newfoundland, Nova Scotia, Quebec, Ontario, Manitoba, Alberta, and British Columbia. This research has been conducted using the CLSA dataset Baseline Comprehensive V5.1, under Application Number 1906015. The CLSA is led by Drs Parminder Raina, Christina Wolfson, and Susan Kirkland. The opinions expressed in this manuscript are the authors' own and do not reflect the views of the Canadian Longitudinal Study on Aging. Publisher Copyright: © 2023 Elsevier Ltd

PY - 2023

Y1 - 2023

N2 - Background: Carotid intima-media thickness (cIMT) provides an index of arterial injury. Frailty is an indicator of vulnerability to adverse health outcomes. It is unclear whether cIMT is associated with the multi-dimensional frailty index and/or if this relationship is age- or sex-specific. The aim was to determine the impact of age and sex on the relationship between cIMT and frailty level in middle-aged and older adults. Methods: Frailty and cIMT data were extracted from the Canadian Longitudinal Study of Aging baseline comprehensive cohort of middle-aged (45–64 years) and older adults (>65 years) (n = 10,209). cIMT was assessed via high-resolution ultrasound. Frailty was determined using a 52-item index. Covariate-adjusted ordinary least squares regressions were conducted separately for middle-aged males (n = 3178), middle-aged females (n = 3125), older males (n = 2031), and older females (n = 1875). Results: Average cIMTs were larger in older versus middle-aged adults and in males versus females (all, p < 0.001). Average cIMT was positively associated with frailty level in adjusted linear regression models in middle-aged males [adj. R2 = 0.09; β = 0.015 (95 % CI: 0.005–0.026), p = 0.004], middle-aged females [adj. R2 = 0.11; β = 0.040 (95 % CI: 0.025–0.054), p < 0.001], older males [adj. R2 = 0.12; β = 0.019 (95 % CI: 0.004–0.034), p = 0.01], and older females [adj. R2 = 0.11; β = 0.020 (95 % CI: 0.002–0.039), p = 0.03]. Conclusion: cIMT was an independent contributor to frailty level regardless of age group (middle-aged/older adults) or sex, with the strongest effect observed in middle-aged females. Our cross-sectional study documents the independent relationship between a marker of cardiovascular function and an increased vulnerability to adverse health outcomes in middle-aged and older males and females.

AB - Background: Carotid intima-media thickness (cIMT) provides an index of arterial injury. Frailty is an indicator of vulnerability to adverse health outcomes. It is unclear whether cIMT is associated with the multi-dimensional frailty index and/or if this relationship is age- or sex-specific. The aim was to determine the impact of age and sex on the relationship between cIMT and frailty level in middle-aged and older adults. Methods: Frailty and cIMT data were extracted from the Canadian Longitudinal Study of Aging baseline comprehensive cohort of middle-aged (45–64 years) and older adults (>65 years) (n = 10,209). cIMT was assessed via high-resolution ultrasound. Frailty was determined using a 52-item index. Covariate-adjusted ordinary least squares regressions were conducted separately for middle-aged males (n = 3178), middle-aged females (n = 3125), older males (n = 2031), and older females (n = 1875). Results: Average cIMTs were larger in older versus middle-aged adults and in males versus females (all, p < 0.001). Average cIMT was positively associated with frailty level in adjusted linear regression models in middle-aged males [adj. R2 = 0.09; β = 0.015 (95 % CI: 0.005–0.026), p = 0.004], middle-aged females [adj. R2 = 0.11; β = 0.040 (95 % CI: 0.025–0.054), p < 0.001], older males [adj. R2 = 0.12; β = 0.019 (95 % CI: 0.004–0.034), p = 0.01], and older females [adj. R2 = 0.11; β = 0.020 (95 % CI: 0.002–0.039), p = 0.03]. Conclusion: cIMT was an independent contributor to frailty level regardless of age group (middle-aged/older adults) or sex, with the strongest effect observed in middle-aged females. Our cross-sectional study documents the independent relationship between a marker of cardiovascular function and an increased vulnerability to adverse health outcomes in middle-aged and older males and females.

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SN - 0914-5087

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Impact of age and sex on the relationship between carotid intima-media thickness and frailty level in the Canadian Longitudinal Study of Aging

Abstract

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PubMed: MeSH publication types

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