Abstract
An auto-anti-IgE response was induced in conventional (PVG-RTI(U) and high IgE-producing (BN) rat strains by immunization with a highly purified rat IgE myeloma IR2. Earlier work established that total serum IgE levels were decreased by this procedure (Marshall & Bell, 1985) but only in the PVG-RTI(U) strain. IR-2-immunized rats were tested for their ability to produce a specific IgE response to ovalbumin (OVA). The primary anti-OVA IgE response was inhibited by 60-75% in both rat strains, regardless of whether the total serum levels of IgE were reduced. The secondary IgE response to OVA was also inhibited in anti-IgE-producing animals but not in rats primed with OVA before anti-IgE induction. The inhibition of the anti-OVA response was isotype specific; the IgG response to OVA was unaffected. These studies may help elucidate the regulatory role played by naturally occurring anti-IgE antibodies found particularly in atopic individuals.
| Original language | English |
|---|---|
| Pages (from-to) | 428-433 |
| Number of pages | 6 |
| Journal | Immunology |
| Volume | 66 |
| Issue number | 3 |
| Publication status | Published - 1989 |
| Externally published | Yes |
ASJC Scopus Subject Areas
- Immunology and Allergy
- Immunology