Abstract
Various reports have indicated that a number of viruses could infect neutrophils, but the multiplication of viruses in neutrophils was abortive. Based on our previous finding that avian influenza viral RNA and proteins were present in the nucleus of infected human neutrophils in vivo, we investigated the possibility of 2009 A (H1N1) influenza viral synthesis in infected neutrophils and possible release of infectious progeny from host cells. In this study we found that human neutrophils in vitro without detectable level of sialic acid expression could be infected by this virus strain. We also show that the infected neutrophils can not only synthesize 2009 A (H1N1) viral mRNA and proteins, but also produce infectious progeny. These findings suggest that infectious progeny of 2009 A (H1N1) influenza virus could be replicated in and released from human neutrophils with possible clinical implications.
| Original language | English |
|---|---|
| Article number | 17809 |
| Journal | Scientific Reports |
| Volume | 5 |
| DOIs | |
| Publication status | Published - Dec 7 2015 |
| Externally published | Yes |
Bibliographical note
Funding Information:We thank Yun Wang, Jing Li, Jin Huang, Chun Ruan, and Zuoqing Su for assistance with the experiments. This work was supported by grants from the Major Program of National Natural Science Foundation of China (81030033).
ASJC Scopus Subject Areas
- General
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't