Abstract
Recombinant inbred strains have been shown to be important tools for segregation and linkage analysis of multifactorial traits. Tests of association have been used as robust methods of linkage detection, however, guidelines for forming inferences from significance levels have not been generally available. In this paper, lessons learned from a Bayesian statistical approach to linkage analysis of Mendelian traits have been applied to studies of multifactorial traits. Criteria for detection of linkage based on Bonferroni's correction for multiple testing are also discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 665-676 |
| Number of pages | 12 |
| Journal | Behavior Genetics |
| Volume | 22 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Nov 1992 |
| Externally published | Yes |
ASJC Scopus Subject Areas
- Ecology, Evolution, Behavior and Systematics
- Genetics
- Genetics(clinical)
PubMed: MeSH publication types
- Journal Article
- Review
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Neumann, P. E. (1992). Inference in linkage analysis of multifactorial traits using recombinant inbred strains of mice. Behavior Genetics, 22(6), 665-676. https://doi.org/10.1007/BF01066637