Information processing by graded-potential transmission through tonically active synapses

Mikko Juusola; Andrew S. French; Raima O. Uusitalo; Matti Weckström

doi:10.1016/S0166-2236(96)10028-X

Information processing by graded-potential transmission through tonically active synapses

Mikko Juusola, Andrew S. French, Raima O. Uusitalo, Matti Weckström

Medicine

Research output: Contribution to journal › Review article › peer-review

130 Citations (Scopus)

Abstract

Many neurons use graded membrane-potential changes, instead of action potentials, to transmit information. Traditional synaptic models feature discontinuous transmitter release by presynaptic action potentials, but this is not true for synapses between graded-potential neurons. In addition to graded and continuous transmitter release, they have multiple active zones, ribbon formations and L-type Ca²⁺ channels. These differences are probably linked to the high rate of vesicle fusion required for continuous transmitter release. Early stages of sensory systems provide some of the best characterized graded-potential neurons, and recent work on these systems suggests that modification of synaptic transmission by adaptation is a powerful feature of graded synapses.

Original language	English
Pages (from-to)	292-297
Number of pages	6
Journal	Trends in Neurosciences
Volume	19
Issue number	7
DOIs	https://doi.org/10.1016/S0166-2236(96)10028-X
Publication status	Published - Jul 1996

Bibliographical note

Funding Information:
We thank Helmut Brandstetter, Roger Hardie, and Ernst-August Seyfarth for their comments and suggestions. This work was supported by grants from the Medical Research Council of Canada, the Academy of Finland, the Emil Aaltonen Foundation and the Oskar Oflund Foundation.

ASJC Scopus Subject Areas

General Neuroscience

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10.1016/S0166-2236(96)10028-X

Cite this

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title = "Information processing by graded-potential transmission through tonically active synapses",

abstract = "Many neurons use graded membrane-potential changes, instead of action potentials, to transmit information. Traditional synaptic models feature discontinuous transmitter release by presynaptic action potentials, but this is not true for synapses between graded-potential neurons. In addition to graded and continuous transmitter release, they have multiple active zones, ribbon formations and L-type Ca2+ channels. These differences are probably linked to the high rate of vesicle fusion required for continuous transmitter release. Early stages of sensory systems provide some of the best characterized graded-potential neurons, and recent work on these systems suggests that modification of synaptic transmission by adaptation is a powerful feature of graded synapses.",

author = "Mikko Juusola and French, {Andrew S.} and Uusitalo, {Raima O.} and Matti Weckstr{\"o}m",

note = "Funding Information: We thank Helmut Brandstetter, Roger Hardie, and Ernst-August Seyfarth for their comments and suggestions. This work was supported by grants from the Medical Research Council of Canada, the Academy of Finland, the Emil Aaltonen Foundation and the Oskar Oflund Foundation.",

year = "1996",

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doi = "10.1016/S0166-2236(96)10028-X",

language = "English",

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pages = "292--297",

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AU - Juusola, Mikko

AU - French, Andrew S.

AU - Uusitalo, Raima O.

AU - Weckström, Matti

N1 - Funding Information: We thank Helmut Brandstetter, Roger Hardie, and Ernst-August Seyfarth for their comments and suggestions. This work was supported by grants from the Medical Research Council of Canada, the Academy of Finland, the Emil Aaltonen Foundation and the Oskar Oflund Foundation.

PY - 1996/7

Y1 - 1996/7

N2 - Many neurons use graded membrane-potential changes, instead of action potentials, to transmit information. Traditional synaptic models feature discontinuous transmitter release by presynaptic action potentials, but this is not true for synapses between graded-potential neurons. In addition to graded and continuous transmitter release, they have multiple active zones, ribbon formations and L-type Ca2+ channels. These differences are probably linked to the high rate of vesicle fusion required for continuous transmitter release. Early stages of sensory systems provide some of the best characterized graded-potential neurons, and recent work on these systems suggests that modification of synaptic transmission by adaptation is a powerful feature of graded synapses.

AB - Many neurons use graded membrane-potential changes, instead of action potentials, to transmit information. Traditional synaptic models feature discontinuous transmitter release by presynaptic action potentials, but this is not true for synapses between graded-potential neurons. In addition to graded and continuous transmitter release, they have multiple active zones, ribbon formations and L-type Ca2+ channels. These differences are probably linked to the high rate of vesicle fusion required for continuous transmitter release. Early stages of sensory systems provide some of the best characterized graded-potential neurons, and recent work on these systems suggests that modification of synaptic transmission by adaptation is a powerful feature of graded synapses.

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Information processing by graded-potential transmission through tonically active synapses

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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