Abstract
This study investigated the impact of exercise training on interindividual variability and response rates in body composition and cardiometabolic outcomes in adolescents with obesity. Postpubertal males and females (n = 143) were randomly assigned to 6 months of a diet-only control or aerobic, resistance, or combined exercise training. Body composition indices were percentages of body fat mass and lean body mass and waist circumference. Biomarkers of cardiometabolic health were systolic blood pressure and plasma fasting glucose, triglycerides, and high-density lipoprotein cholesterol. Interindividual variability was examined by comparing the standard deviation of individual responses (SDIR) to a smallest robust change (SRC). The typical error of measurement was used to classify responses. SDIR exceeded the SRC for percent body fat mass in all exercise groups (SRC = 1.04%; aerobic SDIR = 1.50%; resistance SDIR = 1.22%; combined SDIR = 2.29%), percent lean body mass (SRC = 1.38%; SDIR = 3.2%,), systolic blood pressure (SRC = 2.06 mm Hg; SDIR = 4.92 mm Hg) in the resistance group, and waist circumference (SRC = 2.33 cm; SDIR = 4.09 cm), and fasting glucose (SRC = 0.08 mmol/L; SDIR = 0.28 mmol/L) in the combined group. However, half of the reported variables (11/21) did not have a positive SDIR. Importantly, adverse response rates were significantly lower in all 3 exercise groups compared with control for body composition. Although exercise had a small influence on interindividual variability for indices of body composition, the rate of adverse responses did not increase for any outcome. Novelty � Interindividual variability and individual responses to exercise training have not been investigated in adolescents with obesity. � Six months of exercise training does not increase interindividual variability in adolescents with obesity. � Exercise created a positive, uniform shift in responses.
| Original language | English |
|---|---|
| Pages (from-to) | 45-54 |
| Number of pages | 10 |
| Journal | Applied Physiology, Nutrition and Metabolism |
| Volume | 45 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2020 |
Bibliographical note
Funding Information:The HEARTY trial was supported by grant MCT-71979 from the Canadian Institutes of Health Research. G.S.G. was supported by a New Investigator Award from the Canadian Institutes of Health Research for part of this trial and subsequently by an Endowed Research Chair from the Children’s Hospital of Eastern Ontario Volunteer Association Board. R.J.S. was supported by a Health Senior Scholar award from the Alberta Innovates-Health Solutions and previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. G.P.K. is supported by a University Research Chair from the University of Ottawa. A.S.A. was supported by a Doctoral Student Research Award from the Canadian Diabetes Association during this trial and she is currently supported by a Chercheur Boursier Award Junior 1 from les Fonds de Recherche du Québec-Santé at Concor-dia University. We would like to thank the HEARTY trial participants, as well as Krista Hind, BSc. (deceased), Bruno Lemire, Ph.D., Marta Wein BSc, Kim Robertson, BSc., Kim Fetch, BSc., Brittany Hanlon, MHA, Jane Yardley, Ph.D., Nadia Balaa, BSc., Karen Lopez, BSc., Pamela Martino, MSc., Kim Morin, BSc., Colleen Gilchrist, BSc., RD., Pascale Messier, BSc., RD., Kelley Phillips, MA, and students in the School of Human Kinetics, University of Ottawa, who contributed to study coordination, exercise training, and evaluation of study participants. Robert Ross, Ph.D. (Queens, University, Kingston, Ont., Canada), Alison Bradshaw, MSc., and Jennifer Kuk, Ph.D., (York University, Toronto, Ont., Canada), and Yves Martel, Ph.D., (Tomovision, Magog, Que., Canada) assisted with training and provided ongoing advice on body composition analysis. The Ottawa-Carleton Regional YMCA/YWCA (Ottawa, Ont., Canada), RA Centre (Ottawa, Ont., Canada), Children’s Hospital of Eastern Ontario, and Nautilus Plus and MRI Plus (both in Gatineau, Que., Canada) collaborated throughout the trial. Author contributions: G.S.G., R.J.S., G.P.K, A.S.A., D.P.H., S.D., and S.H. were involved in the design, recruitment, collection, analysis, and dissemination of results from the HEARTY trial. J.J.W., J.T.B., and B.J.G. conceived of and performed the current, secondary analysis, interpreted results, and wrote the manuscript. All authors revised the manuscript and all authors approved of the final version of the manuscript.
Funding Information:
The HEARTY trial was supported by grant MCT-71979 from the Canadian Institutes of Health Research. G.S.G. was supported by a New Investigator Award from the Canadian Institutes of Health Research for part of this trial and subsequently by an Endowed Research Chair from the Children’s Hospital of Eastern Ontario Volunteer Association Board. R.J.S. was supported by a Health Senior Scholar award from the Alberta Innovates-Health Solutions and previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. G.P.K. is supported by a University Research Chair from the University of Ottawa. A.S.A. was supported by a Doctoral Student Research Award from the Canadian Diabetes Association during this trial and she is currently supported by a Chercheur Boursier Award Junior 1 from les Fonds de Recherche du Québec-Santé at Concordia University. We would like to thank the HEARTY trial participants, as well as Krista Hind, BSc. (deceased), Bruno Lemire, Ph.D., Marta Wein BSc, Kim Robertson, BSc., Kim Fetch, BSc., Brittany Hanlon, MHA, Jane Yardley, Ph.D., Nadia Balaa, BSc., Karen Lopez, BSc., Pamela Martino, MSc., Kim Morin, BSc., Colleen Gilchrist, BSc., RD., Pascale Messier, BSc., RD., Kelley Phillips, MA, and students in the School of Human Kinetics, University of Ottawa, who contributed to study coordination, exercise training, and evaluation of study participants. Robert Ross, Ph.D. (Queens, University, Kingston, Ont., Canada), Alison Bradshaw, MSc., and Jennifer Kuk, Ph.D., (York University, Toronto, Ont., Canada), and Yves Martel, Ph.D., (Tomovision, Magog, Que., Canada) assisted with training and provided ongoing advice on body composition analysis. The Ottawa-Carleton Regional YMCA/YWCA (Ottawa, Ont., Canada), RA Centre (Ottawa, Ont., Canada), Children’s Hospital of Eastern Ontario, and Nautilus Plus and MRI Plus (both in Gatineau, Que., Canada) collaborated throughout the trial. Author contributions: G.S.G., R.J.S., G.P.K, A.S.A., D.P.H., S.D., and S.H. were involved in the design, recruitment, collection, analysis, and dissemination of results from the HEARTY trial. J.J.W., J.T.B., and B.J.G. conceived of and performed the current, secondary analysis, interpreted results, and wrote the manuscript. All authors revised the manuscript and all authors approved of the final version of the manuscript.
Publisher Copyright:
© 2020, Canadian Science Publishing. All rights reserved.
ASJC Scopus Subject Areas
- Endocrinology, Diabetes and Metabolism
- Physiology
- Nutrition and Dietetics
- Physiology (medical)
