Intra-amygdala infusion of an end-capped antisense oligodeoxynucleotide to c-fos accelerates amygdala kindling

Bernard J. Chiasson; Murray G.L. Hong; Harold A. Robertson

doi:10.1016/S0169-328X(98)00090-4

Intra-amygdala infusion of an end-capped antisense oligodeoxynucleotide to c-fos accelerates amygdala kindling

Bernard J. Chiasson, Murray G.L. Hong, Harold A. Robertson

Medicine

Medicine

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The changes produced by repeated stimulation of the brain that result in the kindling effect remain unknown. It is known, however, that activation of immediate early genes including c-fos is a very early event in the development of kindling. Here we show that c-fos expression in the amygdala can be knocked-down by an end-capped antisense oligodeoxynucleotide (but not by vehicle, or control antisense oligodeoxynucleotides) and that this results in an acceleration of kindling. These results suggest that, at least in the amygdala, the expression of c-fos is associated with an attempt by the brain to retard the development of kindling.

Original language	English
Pages (from-to)	248-256
Number of pages	9
Journal	Molecular Brain Research
Volume	57
Issue number	2
DOIs	https://doi.org/10.1016/S0169-328X(98)00090-4
Publication status	Published - Jun 15 1998

Bibliographical note

Funding Information:
We would like to thank K.M.A. Murphy for excellent technical assistance during the course of this work. This work was supported by the Medical Research Council of Canada (MT 10440). BJC held a The Savoy Foundation for Epilepsy studentship. MGLH was a Fellow of the Parkinson Foundation of Canada.

ASJC Scopus Subject Areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/S0169-328X(98)00090-4

Cite this

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title = "Intra-amygdala infusion of an end-capped antisense oligodeoxynucleotide to c-fos accelerates amygdala kindling",

abstract = "The changes produced by repeated stimulation of the brain that result in the kindling effect remain unknown. It is known, however, that activation of immediate early genes including c-fos is a very early event in the development of kindling. Here we show that c-fos expression in the amygdala can be knocked-down by an end-capped antisense oligodeoxynucleotide (but not by vehicle, or control antisense oligodeoxynucleotides) and that this results in an acceleration of kindling. These results suggest that, at least in the amygdala, the expression of c-fos is associated with an attempt by the brain to retard the development of kindling.",

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AU - Hong, Murray G.L.

AU - Robertson, Harold A.

N1 - Funding Information: We would like to thank K.M.A. Murphy for excellent technical assistance during the course of this work. This work was supported by the Medical Research Council of Canada (MT 10440). BJC held a The Savoy Foundation for Epilepsy studentship. MGLH was a Fellow of the Parkinson Foundation of Canada.

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N2 - The changes produced by repeated stimulation of the brain that result in the kindling effect remain unknown. It is known, however, that activation of immediate early genes including c-fos is a very early event in the development of kindling. Here we show that c-fos expression in the amygdala can be knocked-down by an end-capped antisense oligodeoxynucleotide (but not by vehicle, or control antisense oligodeoxynucleotides) and that this results in an acceleration of kindling. These results suggest that, at least in the amygdala, the expression of c-fos is associated with an attempt by the brain to retard the development of kindling.

AB - The changes produced by repeated stimulation of the brain that result in the kindling effect remain unknown. It is known, however, that activation of immediate early genes including c-fos is a very early event in the development of kindling. Here we show that c-fos expression in the amygdala can be knocked-down by an end-capped antisense oligodeoxynucleotide (but not by vehicle, or control antisense oligodeoxynucleotides) and that this results in an acceleration of kindling. These results suggest that, at least in the amygdala, the expression of c-fos is associated with an attempt by the brain to retard the development of kindling.

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Intra-amygdala infusion of an end-capped antisense oligodeoxynucleotide to c-fos accelerates amygdala kindling

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Access to Document

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