Investigating the association of receipt of seasonal influenza vaccine with occurrence of anesthesia/paresthesia and severe headaches, Canada 2012/13–2016/17, the Canadian Vaccine Safety Network

for the Canadian Immunization Research Network (CIRN)

doi:10.1016/j.vaccine.2020.03.018

Investigating the association of receipt of seasonal influenza vaccine with occurrence of anesthesia/paresthesia and severe headaches, Canada 2012/13–2016/17, the Canadian Vaccine Safety Network

for the Canadian Immunization Research Network (CIRN)

Medicine

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Background: Concern about adverse events following immunization is frequently cited by both those who receive or decline vaccines. Neurological adverse events are especially concerning. Objectives: Our aim was to detect associations between seasonal influenza vaccination and the occurrence of severe anesthesia/paresthesia or severe headaches. Methods: Data were analyzed from the Canadian National Vaccine Safety network. Events occuring on days 0–7 were self-reported and prevented daily activity, led to school or work absenteeism, or required medical attention. Controls were the previous year's vaccinees; events in controls were collected prior to the start of the influenza vaccination program of each year (2012/13 through 2016/17). Multivariable logistic regression was used to determine the association between seasonal influenza vaccination and the occurrence of anesthesia/paresthesia or severe headaches. Results: The total sample was 107,565 for investigating anesthesia/paresthesia and 97,420 for investigating severe headaches. Anesthesia/paresthesia was reported by 104/107,565 (0.10%) participants; 63/69,129 (0.09%) vaccinees and 41/38,436 (0.11%) controls (adjusted odds ratio (aOR) = 0.89; 95% CI = 0.60, 1.32). Severe headaches were reported by 1361/97,420 (1.40%) participants; 907/61,463 (1.48%) vaccinees and 454/35,957 (1.26%) controls (aOR = 1.21; 95% CI = 1.08, 1.36). No specific vaccine product was associated with severe headaches. Conclusions: Our study found no association between severe anesthesia/paresthesia and seasonal influenza vaccination. While there was an association with severe headaches as an adverse event following influenza vaccination, the rates of these events are similar to rates reported from clinical trials and are not a cause for additional concern.

Original language	English
Pages (from-to)	3582-3590
Number of pages	9
Journal	Vaccine
Volume	38
Issue number	19
DOIs	https://doi.org/10.1016/j.vaccine.2020.03.018
Publication status	Published - Apr 23 2020

Bibliographical note

Funding Information:
JDK has received investigator initiated funding for epidemiologic research from Pfizer and contract clinical trial funding from Merck outside the submitted work.

Funding Information:
KAT has received grants from GSK and consultancy fees from Pfizer outside the submitted work.

Funding Information:
The Canadian National Vaccine Safety Network as part of the Canadian Immunization Research Network is funded by a research grant from the Canadian Institutes of Health Research and the Public Health Agency of Canada grants: #124309 (1 June 2012 – 31 May 2014) , #137470 (1 June 2014 – 31 May 2017) , and #151944 (1 June 2017 – 31 December 2022) .

Publisher Copyright:
© 2020 The Authors

ASJC Scopus Subject Areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.vaccine.2020.03.018

Cite this

Investigating the association of receipt of seasonal influenza vaccine with occurrence of anesthesia/paresthesia and severe headaches, Canada 2012/13–2016/17, the Canadian Vaccine Safety Network. / for the Canadian Immunization Research Network (CIRN).
In: Vaccine, Vol. 38, No. 19, 23.04.2020, p. 3582-3590.

Research output: Contribution to journal › Article › peer-review

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title = "Investigating the association of receipt of seasonal influenza vaccine with occurrence of anesthesia/paresthesia and severe headaches, Canada 2012/13–2016/17, the Canadian Vaccine Safety Network",

abstract = "Background: Concern about adverse events following immunization is frequently cited by both those who receive or decline vaccines. Neurological adverse events are especially concerning. Objectives: Our aim was to detect associations between seasonal influenza vaccination and the occurrence of severe anesthesia/paresthesia or severe headaches. Methods: Data were analyzed from the Canadian National Vaccine Safety network. Events occuring on days 0–7 were self-reported and prevented daily activity, led to school or work absenteeism, or required medical attention. Controls were the previous year's vaccinees; events in controls were collected prior to the start of the influenza vaccination program of each year (2012/13 through 2016/17). Multivariable logistic regression was used to determine the association between seasonal influenza vaccination and the occurrence of anesthesia/paresthesia or severe headaches. Results: The total sample was 107,565 for investigating anesthesia/paresthesia and 97,420 for investigating severe headaches. Anesthesia/paresthesia was reported by 104/107,565 (0.10%) participants; 63/69,129 (0.09%) vaccinees and 41/38,436 (0.11%) controls (adjusted odds ratio (aOR) = 0.89; 95% CI = 0.60, 1.32). Severe headaches were reported by 1361/97,420 (1.40%) participants; 907/61,463 (1.48%) vaccinees and 454/35,957 (1.26%) controls (aOR = 1.21; 95% CI = 1.08, 1.36). No specific vaccine product was associated with severe headaches. Conclusions: Our study found no association between severe anesthesia/paresthesia and seasonal influenza vaccination. While there was an association with severe headaches as an adverse event following influenza vaccination, the rates of these events are similar to rates reported from clinical trials and are not a cause for additional concern.",

author = "{for the Canadian Immunization Research Network (CIRN)} and Ahmed, {May A.} and Monika Naus and Joel Singer and Louis Valiquette and Coleman, {Brenda L.} and {De Serres}, Gaston and Vanderkooi, {Otto G.} and Top, {Karina A.} and Isenor, {Jennifer E.} and Kellner, {James D.} and McCarthy, {Anne E.} and Bettinger, {Julie A.}",

note = "Funding Information: JDK has received investigator initiated funding for epidemiologic research from Pfizer and contract clinical trial funding from Merck outside the submitted work. Funding Information: KAT has received grants from GSK and consultancy fees from Pfizer outside the submitted work. Funding Information: The Canadian National Vaccine Safety Network as part of the Canadian Immunization Research Network is funded by a research grant from the Canadian Institutes of Health Research and the Public Health Agency of Canada grants: #124309 (1 June 2012 – 31 May 2014) , #137470 (1 June 2014 – 31 May 2017) , and #151944 (1 June 2017 – 31 December 2022) . Publisher Copyright: {\textcopyright} 2020 The Authors",

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doi = "10.1016/j.vaccine.2020.03.018",

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T1 - Investigating the association of receipt of seasonal influenza vaccine with occurrence of anesthesia/paresthesia and severe headaches, Canada 2012/13–2016/17, the Canadian Vaccine Safety Network

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AU - Ahmed, May A.

AU - Naus, Monika

AU - Singer, Joel

AU - Valiquette, Louis

AU - Coleman, Brenda L.

AU - De Serres, Gaston

AU - Vanderkooi, Otto G.

AU - Top, Karina A.

AU - Isenor, Jennifer E.

AU - Kellner, James D.

AU - McCarthy, Anne E.

AU - Bettinger, Julie A.

N1 - Funding Information: JDK has received investigator initiated funding for epidemiologic research from Pfizer and contract clinical trial funding from Merck outside the submitted work. Funding Information: KAT has received grants from GSK and consultancy fees from Pfizer outside the submitted work. Funding Information: The Canadian National Vaccine Safety Network as part of the Canadian Immunization Research Network is funded by a research grant from the Canadian Institutes of Health Research and the Public Health Agency of Canada grants: #124309 (1 June 2012 – 31 May 2014) , #137470 (1 June 2014 – 31 May 2017) , and #151944 (1 June 2017 – 31 December 2022) . Publisher Copyright: © 2020 The Authors

PY - 2020/4/23

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N2 - Background: Concern about adverse events following immunization is frequently cited by both those who receive or decline vaccines. Neurological adverse events are especially concerning. Objectives: Our aim was to detect associations between seasonal influenza vaccination and the occurrence of severe anesthesia/paresthesia or severe headaches. Methods: Data were analyzed from the Canadian National Vaccine Safety network. Events occuring on days 0–7 were self-reported and prevented daily activity, led to school or work absenteeism, or required medical attention. Controls were the previous year's vaccinees; events in controls were collected prior to the start of the influenza vaccination program of each year (2012/13 through 2016/17). Multivariable logistic regression was used to determine the association between seasonal influenza vaccination and the occurrence of anesthesia/paresthesia or severe headaches. Results: The total sample was 107,565 for investigating anesthesia/paresthesia and 97,420 for investigating severe headaches. Anesthesia/paresthesia was reported by 104/107,565 (0.10%) participants; 63/69,129 (0.09%) vaccinees and 41/38,436 (0.11%) controls (adjusted odds ratio (aOR) = 0.89; 95% CI = 0.60, 1.32). Severe headaches were reported by 1361/97,420 (1.40%) participants; 907/61,463 (1.48%) vaccinees and 454/35,957 (1.26%) controls (aOR = 1.21; 95% CI = 1.08, 1.36). No specific vaccine product was associated with severe headaches. Conclusions: Our study found no association between severe anesthesia/paresthesia and seasonal influenza vaccination. While there was an association with severe headaches as an adverse event following influenza vaccination, the rates of these events are similar to rates reported from clinical trials and are not a cause for additional concern.

AB - Background: Concern about adverse events following immunization is frequently cited by both those who receive or decline vaccines. Neurological adverse events are especially concerning. Objectives: Our aim was to detect associations between seasonal influenza vaccination and the occurrence of severe anesthesia/paresthesia or severe headaches. Methods: Data were analyzed from the Canadian National Vaccine Safety network. Events occuring on days 0–7 were self-reported and prevented daily activity, led to school or work absenteeism, or required medical attention. Controls were the previous year's vaccinees; events in controls were collected prior to the start of the influenza vaccination program of each year (2012/13 through 2016/17). Multivariable logistic regression was used to determine the association between seasonal influenza vaccination and the occurrence of anesthesia/paresthesia or severe headaches. Results: The total sample was 107,565 for investigating anesthesia/paresthesia and 97,420 for investigating severe headaches. Anesthesia/paresthesia was reported by 104/107,565 (0.10%) participants; 63/69,129 (0.09%) vaccinees and 41/38,436 (0.11%) controls (adjusted odds ratio (aOR) = 0.89; 95% CI = 0.60, 1.32). Severe headaches were reported by 1361/97,420 (1.40%) participants; 907/61,463 (1.48%) vaccinees and 454/35,957 (1.26%) controls (aOR = 1.21; 95% CI = 1.08, 1.36). No specific vaccine product was associated with severe headaches. Conclusions: Our study found no association between severe anesthesia/paresthesia and seasonal influenza vaccination. While there was an association with severe headaches as an adverse event following influenza vaccination, the rates of these events are similar to rates reported from clinical trials and are not a cause for additional concern.

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Investigating the association of receipt of seasonal influenza vaccine with occurrence of anesthesia/paresthesia and severe headaches, Canada 2012/13–2016/17, the Canadian Vaccine Safety Network

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

Access to Document

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