TY - JOUR
T1 - Kawasaki disease and immunisation
T2 - A systematic review
AU - The Brighton Collaboration Kawasaki Disease (KD) Working Group
AU - Phuong, Linny Kimly
AU - Bonetto, Caterina
AU - Buttery, Jim
AU - Pernus, Yolanda Brauchli
AU - Chandler, Rebecca
AU - Felicetti, Patrizia
AU - Goldenthal, Karen L.
AU - Kucuku, Merita
AU - Monaco, Giuseppe
AU - Pahud, Barbara
AU - Shulman, Stanford T.
AU - Top, Karina A.
AU - Trotta, Francesco
AU - Ulloa-Gutierrez, Rolando
AU - Varricchio, Frederick
AU - de Ferranti, Sarah
AU - Newburger, Jane W.
AU - Dahdah, Nagib
AU - Singh, Surjit
AU - Bonhoeffer, Jan
AU - Burgner, David
N1 - Publisher Copyright:
© 2016
PY - 2017/3/27
Y1 - 2017/3/27
N2 - Background Kawasaki disease is a complex and potentially serious condition. It has been observed in temporal relation to immunisation. Methods We conducted a systematic literature review using various reference sources to review the available evidence published in the literature. Results We identified twenty seven publications reporting a temporal association between immunisation and Kawasaki disease. We present a systematic review of data drawn from randomised controlled trials, observational studies, case series and reports, and reviews. Overall there was a lack of standardised case definitions, making data interpretation and comparability challenging. Conclusions Although a temporal relationship between immunisation and Kawasaki disease is suggested, evidence for an increased risk or a causal association is lacking. Implementation of a standardised Kawasaki disease case definition would increase confidence in the findings and add value to future studies of pre- or post-licensure vaccine safety studies.
AB - Background Kawasaki disease is a complex and potentially serious condition. It has been observed in temporal relation to immunisation. Methods We conducted a systematic literature review using various reference sources to review the available evidence published in the literature. Results We identified twenty seven publications reporting a temporal association between immunisation and Kawasaki disease. We present a systematic review of data drawn from randomised controlled trials, observational studies, case series and reports, and reviews. Overall there was a lack of standardised case definitions, making data interpretation and comparability challenging. Conclusions Although a temporal relationship between immunisation and Kawasaki disease is suggested, evidence for an increased risk or a causal association is lacking. Implementation of a standardised Kawasaki disease case definition would increase confidence in the findings and add value to future studies of pre- or post-licensure vaccine safety studies.
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U2 - 10.1016/j.vaccine.2016.09.033
DO - 10.1016/j.vaccine.2016.09.033
M3 - Article
C2 - 28259442
AN - SCOPUS:85014089632
SN - 0264-410X
VL - 35
SP - 1770
EP - 1779
JO - Vaccine
JF - Vaccine
IS - 14
ER -
