Lateral Gene Transfer Mechanisms and Pan-genomes in Eukaryotes

Shannon J. Sibbald; Laura Eme; John M. Archibald; Andrew J. Roger

doi:10.1016/j.pt.2020.07.014

Lateral Gene Transfer Mechanisms and Pan-genomes in Eukaryotes

Shannon J. Sibbald, Laura Eme, John M. Archibald, Andrew J. Roger

Medicine

Research output: Contribution to journal › Review article › peer-review

47 Citations (Scopus)

Abstract

Lateral gene transfer (LGT) is well known as an important driver of genome evolution in bacteria and archaea, but its importance in eukaryote evolution has yet to be fully elucidated. There is now abundant evidence indicating that LGT has played a role in the adaptation of eukaryotes to new environments and conditions, including host–parasite interactions. However, the mechanisms and frequency of LGT across the tree of eukaryotes remain poorly understood. Here we review evidence for known and potential mechanisms of LGT into diverse eukaryote lineages with a particular focus on protists, and we discuss trends emerging from recently reported examples. We also explore the potential role of LGT in generating ‘pan-genomes’ in diverse eukaryotic species.

Original language	English
Pages (from-to)	927-941
Number of pages	15
Journal	Trends in Parasitology
Volume	36
Issue number	11
DOIs	https://doi.org/10.1016/j.pt.2020.07.014
Publication status	Published - Nov 2020

Bibliographical note

Funding Information:
We thank the reviewers for a number of constructive suggestions and apologize to authors whose work could not be cited due to length constraints. S.S. was supported by a CGS-D scholarship from the Natural Sciences and Engineering Research Council of Canada . The work was also supported by a Foundation Grant, FRN-142349 , from the Canadian Institutes of Health Research awarded to A.J.R., a Symbiosis Grant from the Moore Foundation awarded to J.M.A., and L.E. is supported by funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 803151 ).

Funding Information:
We thank the reviewers for a number of constructive suggestions and apologize to authors whose work could not be cited due to length constraints. S.S. was supported by a CGS-D scholarship from the Natural Sciences and Engineering Research Council of Canada. The work was also supported by a Foundation Grant, FRN-142349, from the Canadian Institutes of Health Research awarded to A.J.R. a Symbiosis Grant from the Moore Foundation awarded to J.M.A. and L.E. is supported by funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement No 803151).

Publisher Copyright:
© 2020 Elsevier Ltd

ASJC Scopus Subject Areas

Parasitology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pt.2020.07.014

Cite this

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abstract = "Lateral gene transfer (LGT) is well known as an important driver of genome evolution in bacteria and archaea, but its importance in eukaryote evolution has yet to be fully elucidated. There is now abundant evidence indicating that LGT has played a role in the adaptation of eukaryotes to new environments and conditions, including host–parasite interactions. However, the mechanisms and frequency of LGT across the tree of eukaryotes remain poorly understood. Here we review evidence for known and potential mechanisms of LGT into diverse eukaryote lineages with a particular focus on protists, and we discuss trends emerging from recently reported examples. We also explore the potential role of LGT in generating {\textquoteleft}pan-genomes{\textquoteright} in diverse eukaryotic species.",

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note = "Funding Information: We thank the reviewers for a number of constructive suggestions and apologize to authors whose work could not be cited due to length constraints. S.S. was supported by a CGS-D scholarship from the Natural Sciences and Engineering Research Council of Canada . The work was also supported by a Foundation Grant, FRN-142349 , from the Canadian Institutes of Health Research awarded to A.J.R., a Symbiosis Grant from the Moore Foundation awarded to J.M.A., and L.E. is supported by funding from the European Research Council (ERC) under the European Union{\textquoteright}s Horizon 2020 research and innovation programme (grant agreement No 803151 ). Funding Information: We thank the reviewers for a number of constructive suggestions and apologize to authors whose work could not be cited due to length constraints. S.S. was supported by a CGS-D scholarship from the Natural Sciences and Engineering Research Council of Canada. The work was also supported by a Foundation Grant, FRN-142349, from the Canadian Institutes of Health Research awarded to A.J.R. a Symbiosis Grant from the Moore Foundation awarded to J.M.A. and L.E. is supported by funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement No 803151). Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

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N2 - Lateral gene transfer (LGT) is well known as an important driver of genome evolution in bacteria and archaea, but its importance in eukaryote evolution has yet to be fully elucidated. There is now abundant evidence indicating that LGT has played a role in the adaptation of eukaryotes to new environments and conditions, including host–parasite interactions. However, the mechanisms and frequency of LGT across the tree of eukaryotes remain poorly understood. Here we review evidence for known and potential mechanisms of LGT into diverse eukaryote lineages with a particular focus on protists, and we discuss trends emerging from recently reported examples. We also explore the potential role of LGT in generating ‘pan-genomes’ in diverse eukaryotic species.

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Lateral Gene Transfer Mechanisms and Pan-genomes in Eukaryotes

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

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