Lesions dorsal to the suprachiasmatic nuclei abolish split activity rhythms of hamsters

M. E. Harrington; G. A. Eskes; P. Dickson; B. Rusak

doi:10.1016/0361-9230(90)90164-U

Lesions dorsal to the suprachiasmatic nuclei abolish split activity rhythms of hamsters

M. E. Harrington, G. A. Eskes, P. Dickson, B. Rusak

Medicine

Medicine

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Constant light exposure (LL) can result in "splitting" of circadian rhythms into two components coupled about 12 hr apart. Splitting has been interpreted as evidence for the presence of two main oscillators or groups of oscillators underlying circadian rhythms. Abolition of splitting after unilateral suprachiasmatic nucleus ablation suggested that each suprachiasmatic nucleus could correspond to one of these component oscillators. We examined whether lesions outside the suprachiasmatic nuclei (SCN) would abolish split activity rhythms of hamsters in LL. Wheel-running activity was recorded for 3 months after surgery. Tissue damage was assessed by Klüver-Barrera staining. Damage to areas dorso-caudal to the SCN was able to abolish the split condition. Bilateral damage to the anterior SCN, partial unilateral SCN ablation or unilateral periventricular damage also abolished the split pattern. These results indicate that destruction of one SCN is not essential for the elimination of split rhythms since lesions dorsal to the SCN or partial bilateral SCN damage are also effective. Indirect lesion effects on SCN function or damage to extra-SCN oscillators may account for the loss of the split condition.

Original language	English
Pages (from-to)	593-597
Number of pages	5
Journal	Brain Research Bulletin
Volume	24
Issue number	4
DOIs	https://doi.org/10.1016/0361-9230(90)90164-U
Publication status	Published - Apr 1990

Bibliographical note

Funding Information:
We are very gratefutlo D. GoguenM, . Jain, M. Prince,T . Rahmani, D. Burger, M. Pufall and J. Needles for their skilled technical assistance and to J. Meijer for helpful discussions. This researchw as supportedb y grants from Medical Research Council of Canada (MA8929), Natural Science and Engineering ResearchC ouncil of Canada (AO305), Daihousie University RDFS, Smith College Committeeo n Faculty Compensationa nd Development,a nd National Instituteso f Health (NS26496).

ASJC Scopus Subject Areas

General Neuroscience

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

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10.1016/0361-9230(90)90164-U

Cite this

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title = "Lesions dorsal to the suprachiasmatic nuclei abolish split activity rhythms of hamsters",

abstract = "Constant light exposure (LL) can result in {"}splitting{"} of circadian rhythms into two components coupled about 12 hr apart. Splitting has been interpreted as evidence for the presence of two main oscillators or groups of oscillators underlying circadian rhythms. Abolition of splitting after unilateral suprachiasmatic nucleus ablation suggested that each suprachiasmatic nucleus could correspond to one of these component oscillators. We examined whether lesions outside the suprachiasmatic nuclei (SCN) would abolish split activity rhythms of hamsters in LL. Wheel-running activity was recorded for 3 months after surgery. Tissue damage was assessed by Kl{\"u}ver-Barrera staining. Damage to areas dorso-caudal to the SCN was able to abolish the split condition. Bilateral damage to the anterior SCN, partial unilateral SCN ablation or unilateral periventricular damage also abolished the split pattern. These results indicate that destruction of one SCN is not essential for the elimination of split rhythms since lesions dorsal to the SCN or partial bilateral SCN damage are also effective. Indirect lesion effects on SCN function or damage to extra-SCN oscillators may account for the loss of the split condition.",

author = "Harrington, {M. E.} and Eskes, {G. A.} and P. Dickson and B. Rusak",

note = "Funding Information: We are very gratefutlo D. GoguenM, . Jain, M. Prince,T . Rahmani, D. Burger, M. Pufall and J. Needles for their skilled technical assistance and to J. Meijer for helpful discussions. This researchw as supportedb y grants from Medical Research Council of Canada (MA8929), Natural Science and Engineering ResearchC ouncil of Canada (AO305), Daihousie University RDFS, Smith College Committeeo n Faculty Compensationa nd Development,a nd National Instituteso f Health (NS26496).",

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AU - Rusak, B.

N1 - Funding Information: We are very gratefutlo D. GoguenM, . Jain, M. Prince,T . Rahmani, D. Burger, M. Pufall and J. Needles for their skilled technical assistance and to J. Meijer for helpful discussions. This researchw as supportedb y grants from Medical Research Council of Canada (MA8929), Natural Science and Engineering ResearchC ouncil of Canada (AO305), Daihousie University RDFS, Smith College Committeeo n Faculty Compensationa nd Development,a nd National Instituteso f Health (NS26496).

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N2 - Constant light exposure (LL) can result in "splitting" of circadian rhythms into two components coupled about 12 hr apart. Splitting has been interpreted as evidence for the presence of two main oscillators or groups of oscillators underlying circadian rhythms. Abolition of splitting after unilateral suprachiasmatic nucleus ablation suggested that each suprachiasmatic nucleus could correspond to one of these component oscillators. We examined whether lesions outside the suprachiasmatic nuclei (SCN) would abolish split activity rhythms of hamsters in LL. Wheel-running activity was recorded for 3 months after surgery. Tissue damage was assessed by Klüver-Barrera staining. Damage to areas dorso-caudal to the SCN was able to abolish the split condition. Bilateral damage to the anterior SCN, partial unilateral SCN ablation or unilateral periventricular damage also abolished the split pattern. These results indicate that destruction of one SCN is not essential for the elimination of split rhythms since lesions dorsal to the SCN or partial bilateral SCN damage are also effective. Indirect lesion effects on SCN function or damage to extra-SCN oscillators may account for the loss of the split condition.

AB - Constant light exposure (LL) can result in "splitting" of circadian rhythms into two components coupled about 12 hr apart. Splitting has been interpreted as evidence for the presence of two main oscillators or groups of oscillators underlying circadian rhythms. Abolition of splitting after unilateral suprachiasmatic nucleus ablation suggested that each suprachiasmatic nucleus could correspond to one of these component oscillators. We examined whether lesions outside the suprachiasmatic nuclei (SCN) would abolish split activity rhythms of hamsters in LL. Wheel-running activity was recorded for 3 months after surgery. Tissue damage was assessed by Klüver-Barrera staining. Damage to areas dorso-caudal to the SCN was able to abolish the split condition. Bilateral damage to the anterior SCN, partial unilateral SCN ablation or unilateral periventricular damage also abolished the split pattern. These results indicate that destruction of one SCN is not essential for the elimination of split rhythms since lesions dorsal to the SCN or partial bilateral SCN damage are also effective. Indirect lesion effects on SCN function or damage to extra-SCN oscillators may account for the loss of the split condition.

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Lesions dorsal to the suprachiasmatic nuclei abolish split activity rhythms of hamsters

Abstract

Bibliographical note

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