Ly49 knockdown in mice results in aberrant uterine crypt formation and impaired blastocyst implantation

Lucy Leon; Allison M. Felker; Vanessa R. Kay; Megan M. Tu; Andrew P. Makrigiannis; B. Anne Croy

doi:10.1016/j.placenta.2016.01.013

Ly49 knockdown in mice results in aberrant uterine crypt formation and impaired blastocyst implantation

Lucy Leon, Allison M. Felker, Vanessa R. Kay, Megan M. Tu, Andrew P. Makrigiannis, B. Anne Croy

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Genetic knockdown (KD) of the mouse Ly49 receptor family is reported to result in infertility despite the presence of zona-enclosed blastocysts in the uterus. Ly49 receptors regulate leukocyte functions particularly Natural Killer (NK) cell functions and are analogous to human killer immunoglobulin-like receptors (KIRs). Histological analyses of gd3.5-4.5 B6.Ly49^KD uteri identified hatched but retarded blastocysts with pyknotic nuclei, aberrant endometrial crypt formation and impaired uterine lumen closure accompanied by a lack of primary decidualization These data support peri-implantation roles for leukocytes expressing the Ly49 receptor repertoire and may give insight into KIR-based regulation of human infertility.

Original language	English
Pages (from-to)	147-150
Number of pages	4
Journal	Placenta
Volume	39
DOIs	https://doi.org/10.1016/j.placenta.2016.01.013
Publication status	Published - Mar 1 2016
Externally published	Yes

Bibliographical note

Funding Information:
We thank Dr. Patricia Lima, Ottawa Hospital Research Institute , for helpful discussions. These studies were supported by an award from NSERC (BAC) ( 3219-2011 ).

Publisher Copyright:
© 2016 Elsevier Ltd. All rights reserved.

ASJC Scopus Subject Areas

Reproductive Medicine
Obstetrics and Gynaecology
Developmental Biology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

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10.1016/j.placenta.2016.01.013

Cite this

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title = "Ly49 knockdown in mice results in aberrant uterine crypt formation and impaired blastocyst implantation",

abstract = "Genetic knockdown (KD) of the mouse Ly49 receptor family is reported to result in infertility despite the presence of zona-enclosed blastocysts in the uterus. Ly49 receptors regulate leukocyte functions particularly Natural Killer (NK) cell functions and are analogous to human killer immunoglobulin-like receptors (KIRs). Histological analyses of gd3.5-4.5 B6.Ly49KD uteri identified hatched but retarded blastocysts with pyknotic nuclei, aberrant endometrial crypt formation and impaired uterine lumen closure accompanied by a lack of primary decidualization These data support peri-implantation roles for leukocytes expressing the Ly49 receptor repertoire and may give insight into KIR-based regulation of human infertility.",

author = "Lucy Leon and Felker, {Allison M.} and Kay, {Vanessa R.} and Tu, {Megan M.} and Makrigiannis, {Andrew P.} and Croy, {B. Anne}",

note = "Funding Information: We thank Dr. Patricia Lima, Ottawa Hospital Research Institute , for helpful discussions. These studies were supported by an award from NSERC (BAC) ( 3219-2011 ). Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd. All rights reserved.",

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doi = "10.1016/j.placenta.2016.01.013",

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AU - Leon, Lucy

AU - Felker, Allison M.

AU - Kay, Vanessa R.

AU - Tu, Megan M.

AU - Makrigiannis, Andrew P.

AU - Croy, B. Anne

N1 - Funding Information: We thank Dr. Patricia Lima, Ottawa Hospital Research Institute , for helpful discussions. These studies were supported by an award from NSERC (BAC) ( 3219-2011 ). Publisher Copyright: © 2016 Elsevier Ltd. All rights reserved.

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Y1 - 2016/3/1

N2 - Genetic knockdown (KD) of the mouse Ly49 receptor family is reported to result in infertility despite the presence of zona-enclosed blastocysts in the uterus. Ly49 receptors regulate leukocyte functions particularly Natural Killer (NK) cell functions and are analogous to human killer immunoglobulin-like receptors (KIRs). Histological analyses of gd3.5-4.5 B6.Ly49KD uteri identified hatched but retarded blastocysts with pyknotic nuclei, aberrant endometrial crypt formation and impaired uterine lumen closure accompanied by a lack of primary decidualization These data support peri-implantation roles for leukocytes expressing the Ly49 receptor repertoire and may give insight into KIR-based regulation of human infertility.

AB - Genetic knockdown (KD) of the mouse Ly49 receptor family is reported to result in infertility despite the presence of zona-enclosed blastocysts in the uterus. Ly49 receptors regulate leukocyte functions particularly Natural Killer (NK) cell functions and are analogous to human killer immunoglobulin-like receptors (KIRs). Histological analyses of gd3.5-4.5 B6.Ly49KD uteri identified hatched but retarded blastocysts with pyknotic nuclei, aberrant endometrial crypt formation and impaired uterine lumen closure accompanied by a lack of primary decidualization These data support peri-implantation roles for leukocytes expressing the Ly49 receptor repertoire and may give insight into KIR-based regulation of human infertility.

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Ly49 knockdown in mice results in aberrant uterine crypt formation and impaired blastocyst implantation

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Access to Document

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