Mast-cell responses to pathogens

Research output: Contribution to journalReview articlepeer-review

726 Citations (Scopus)

Abstract

Mast cells have mainly been studied in the setting of allergic disease, but the importance of mast cells for host defence against several pathogens has now been well established. The location of mast cells, which are found closely associated with blood vessels, allows them to have a crucial sentinel role in host defence. The mast cell has a unique 'armamentarium' of receptor systems and mediators for responding to pathogen-associated signals. Studies of this intriguing immune-effector cell provide important insights into the complex mechanisms by which appropriate innate and acquired immune responses are initiated.

Original languageEnglish
Pages (from-to)787-799
Number of pages13
JournalNature Reviews Immunology
Volume4
Issue number10
DOIs
Publication statusPublished - Oct 2004

ASJC Scopus Subject Areas

  • Immunology and Allergy
  • Immunology

PubMed: MeSH publication types

  • Journal Article
  • Review

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