TY - JOUR
T1 - Methamphetamine dependence increases risk of neuropsychological impairment in HIV infected persons
AU - Rippeth, Julie D.
AU - Heaton, Robert K.
AU - Carey, Catherine L.
AU - Marnotte, Thomas S.
AU - Moore, David J.
AU - Gonzalez, Raul
AU - Wolfson, Tanya
AU - Grant, Igor
AU - Atkinson, J. Hampton
AU - McCutchan, J. Allen
AU - Marcotte, Thomas D.
AU - Wallace, Mark R.
AU - Ellis, Ronald J.
AU - Letendre, Scott
AU - Schrier, Rachel
AU - Heaton, Robert K.
AU - Cherner, Mariana
AU - Rippeth, Julie
AU - Sadek, Joseph
AU - Woods, Steve Paul
AU - Jernigan, Terry
AU - Hasselink, John
AU - Masliah, Eliezer
AU - Maysy, Daniel R.
AU - Frybarger, Michelle
AU - Abramson, Ian
AU - Deutsch, Reena
AU - Lazzaretto, Deborah
AU - Wolfson, Tanya
PY - 2004/1
Y1 - 2004/1
N2 - Both HIV infection and methamphetamine dependence can be associated with brain dysfunction. Little is known, however, about the cognitive effects of concurrent HIV infection and methamphetamine depence. The present study included 200 participants in 4 groups: HIV infected/ methamphetamine dependent (HIV+/METH+), HIV negative/methamphetamine dependent (HIV-/METH+), HIV infected/methamphetamine nondependent (HIV+/METH-), and HIV negative/methamphetamine nondependent (HIV-/METH-). Study groups were comparable for age, education, and ethnicity, although the HIV-/METH- group had significantly more females. A comprehensive, demographically corrected neuropsychological battery was administered yielding a global performance score and scores for seven neurobehavioral domains. Rates of neuropsychological impairment were determined by cutoff scores derived from performances of a separate control group and validated with larger samples of HIV+ and HIV- participants from an independent cohort. Rates of global neuropsychological impairment were higher in the HIV+/METH+ (58%), HIV-/METH+ (40%) and HIV+/METH- (38%) groups compared to the HIV-/METH- (18%) group. Nonparametric analyses revealed a significant monotonic trend for global cognitive status across groups, with least impairment in the control group and highest prevalence of impairment in the group with concurrent HIV infection and methamphetamine dependence, The results indicate that HIV infection and methamphetamine dependence are each associated with neuropsychological deficits, and suggest that these factors in combination are associated with additive deleterious cognitive effects. This additivity may reflect common pathways to neural injury involving both cytotoxic and apoptotic mechanisms.
AB - Both HIV infection and methamphetamine dependence can be associated with brain dysfunction. Little is known, however, about the cognitive effects of concurrent HIV infection and methamphetamine depence. The present study included 200 participants in 4 groups: HIV infected/ methamphetamine dependent (HIV+/METH+), HIV negative/methamphetamine dependent (HIV-/METH+), HIV infected/methamphetamine nondependent (HIV+/METH-), and HIV negative/methamphetamine nondependent (HIV-/METH-). Study groups were comparable for age, education, and ethnicity, although the HIV-/METH- group had significantly more females. A comprehensive, demographically corrected neuropsychological battery was administered yielding a global performance score and scores for seven neurobehavioral domains. Rates of neuropsychological impairment were determined by cutoff scores derived from performances of a separate control group and validated with larger samples of HIV+ and HIV- participants from an independent cohort. Rates of global neuropsychological impairment were higher in the HIV+/METH+ (58%), HIV-/METH+ (40%) and HIV+/METH- (38%) groups compared to the HIV-/METH- (18%) group. Nonparametric analyses revealed a significant monotonic trend for global cognitive status across groups, with least impairment in the control group and highest prevalence of impairment in the group with concurrent HIV infection and methamphetamine dependence, The results indicate that HIV infection and methamphetamine dependence are each associated with neuropsychological deficits, and suggest that these factors in combination are associated with additive deleterious cognitive effects. This additivity may reflect common pathways to neural injury involving both cytotoxic and apoptotic mechanisms.
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U2 - 10.1017/S1355617704101021
DO - 10.1017/S1355617704101021
M3 - Article
C2 - 14751002
AN - SCOPUS:9144232221
SN - 1355-6177
VL - 10
SP - 1
EP - 14
JO - Journal of the International Neuropsychological Society
JF - Journal of the International Neuropsychological Society
IS - 1
ER -
