TY - JOUR
T1 - Method of administration influences the serum cholesterol-lowering effect of psyllium
AU - Wolever, Thomas M.S.
AU - Jenkins, David J.A.
AU - Mueller, Sharon
AU - Boctor, Dana L.
AU - Ransom, Thomas P.P.
AU - Patten, Robert
AU - Chao, Eunice S.M.
AU - McMillan, Kenneth
AU - Fulgoni, Victor
PY - 1994/5
Y1 - 1994/5
N2 - To determine whether psyllium must be mixed with food to lower serum cholesterol, 18 modestly hypercholesterolemic subjects were studied for three 2-wk periods, in random order, separated by a 2-wk return to a National Cholesterol Education Program Step 2 diet. Compared with values for subjects consuming control wheat-bran cereal (63 g/d), after 2 wk of 54 g psyllium- enriched cereal/d containing 7.3 g psyllium, serum total, LDL, and HDL cholesterol, respectively, were reduced by 8% (6.15 ± 0.15 vs 6.71 ± 0.19 mmol/L, P < 0.01), 11% (4.24 ± 0.15 vs 4.78 ± 0.19 mmol/L, P < 0.02), and 7% (0.99 ± 0.05 vs 1.07 ± 0.05 mmol/L, P < 0.01). When 7.6 g of the same type of psyllium as in the test cereal was taken between meals, serum total (6.50 ± 0.19 mmol/L), LDL (4.50 ± 0.21 mmol/L), and HDL (1.06 ± 0.06 mmol/L) cholesterol were no different from control values, and total cholesterol was greater than after psyllium cereal (P < 0.05). We conclude that psyllium must be mixed with foods to have the maximum effect on serum cholesterol.
AB - To determine whether psyllium must be mixed with food to lower serum cholesterol, 18 modestly hypercholesterolemic subjects were studied for three 2-wk periods, in random order, separated by a 2-wk return to a National Cholesterol Education Program Step 2 diet. Compared with values for subjects consuming control wheat-bran cereal (63 g/d), after 2 wk of 54 g psyllium- enriched cereal/d containing 7.3 g psyllium, serum total, LDL, and HDL cholesterol, respectively, were reduced by 8% (6.15 ± 0.15 vs 6.71 ± 0.19 mmol/L, P < 0.01), 11% (4.24 ± 0.15 vs 4.78 ± 0.19 mmol/L, P < 0.02), and 7% (0.99 ± 0.05 vs 1.07 ± 0.05 mmol/L, P < 0.01). When 7.6 g of the same type of psyllium as in the test cereal was taken between meals, serum total (6.50 ± 0.19 mmol/L), LDL (4.50 ± 0.21 mmol/L), and HDL (1.06 ± 0.06 mmol/L) cholesterol were no different from control values, and total cholesterol was greater than after psyllium cereal (P < 0.05). We conclude that psyllium must be mixed with foods to have the maximum effect on serum cholesterol.
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U2 - 10.1093/ajcn/59.5.1055
DO - 10.1093/ajcn/59.5.1055
M3 - Article
C2 - 8172091
AN - SCOPUS:0028331547
SN - 0002-9165
VL - 59
SP - 1055
EP - 1059
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 5
ER -