TY - JOUR
T1 - Miliary Mycobacterium bovis induced by intravesical bacille Calmette- Guerin immunotherapy
AU - McParland, C.
AU - Cotton, D. J.
AU - Gowda, K. S.
AU - Hoeppner, V. H.
AU - Martin, W. T.
AU - Weckworth, P. F.
PY - 1992
Y1 - 1992
N2 - Intravesical instillation of bacille Calmette-Guerin (BCG), an attenuated strain of Mycobacterium bovis, is the treatment of choice for many patients with bladder cancer. In a small percentage, this therapy is associated with systemic side effects including pneumonitis. It is uncertain whether these systemic manifestations are due to dissemination of infection or due to hypersensitivity, an etiologic distinction that has important therapeutic implications. We report the first case in which miliary M. bovis was proven to be the responsible mechanism, by culture of M. bovis biovar BCG from a transbronchial lung biopsy and complete resolution on anti-tuberculous chemotherapy.
AB - Intravesical instillation of bacille Calmette-Guerin (BCG), an attenuated strain of Mycobacterium bovis, is the treatment of choice for many patients with bladder cancer. In a small percentage, this therapy is associated with systemic side effects including pneumonitis. It is uncertain whether these systemic manifestations are due to dissemination of infection or due to hypersensitivity, an etiologic distinction that has important therapeutic implications. We report the first case in which miliary M. bovis was proven to be the responsible mechanism, by culture of M. bovis biovar BCG from a transbronchial lung biopsy and complete resolution on anti-tuberculous chemotherapy.
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U2 - 10.1164/ajrccm/146.5_Pt_1.1330
DO - 10.1164/ajrccm/146.5_Pt_1.1330
M3 - Article
C2 - 1443892
AN - SCOPUS:0026452398
SN - 0003-0805
VL - 146
SP - 1330
EP - 1333
JO - American Review of Respiratory Disease
JF - American Review of Respiratory Disease
IS - 5
ER -
