Modulation of the endocannabinoid system following central nervous system injury

Juan Zhou; Haneen Noori; Ian Burkovskiy; J. Daniel Lafreniere; Melanie E.M. Kelly; Christian Lehmann

doi:10.3390/ijms20020388

Modulation of the endocannabinoid system following central nervous system injury

Juan Zhou, Haneen Noori, Ian Burkovskiy, J. Daniel Lafreniere, Melanie E.M. Kelly, Christian Lehmann

Medicine

Research output: Contribution to journal › Review article › peer-review

16 Citations (Scopus)

Abstract

Central nervous system (CNS) injury, such as stroke or trauma, is known to increase susceptibility to various infections that adversely affect patient outcomes (CNS injury-induced immunodepression— CIDS). The endocannabinoid system (ECS) has been shown to have immunoregulatory properties. Therefore, the ECS might represent a druggable target to overcome CIDS. Evidence suggests that cannabinoid type 2 receptor (CB ₂ R) activation can be protective during the early pro-inflammatory phase after CNS injury, as it limits neuro-inflammation and, therefore, attenuates CIDS severity. In the later phase post CNS injury, CB ₂ R inhibition is suggested as a promising pharmacologic strategy to restore immune function in order to prevent infection.

Original language	English
Article number	388
Journal	International Journal of Molecular Sciences
Volume	20
Issue number	2
DOIs	https://doi.org/10.3390/ijms20020388
Publication status	Published - Jan 2 2019

Bibliographical note

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

ASJC Scopus Subject Areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

PubMed: MeSH publication types

Journal Article
Review

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10.3390/ijms20020388

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Zhou, J., Noori, H., Burkovskiy, I., Lafreniere, J. D., Kelly, M. E. M., & Lehmann, C. (2019). Modulation of the endocannabinoid system following central nervous system injury. International Journal of Molecular Sciences, 20(2), Article 388. https://doi.org/10.3390/ijms20020388

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abstract = " Central nervous system (CNS) injury, such as stroke or trauma, is known to increase susceptibility to various infections that adversely affect patient outcomes (CNS injury-induced immunodepression— CIDS). The endocannabinoid system (ECS) has been shown to have immunoregulatory properties. Therefore, the ECS might represent a druggable target to overcome CIDS. Evidence suggests that cannabinoid type 2 receptor (CB 2 R) activation can be protective during the early pro-inflammatory phase after CNS injury, as it limits neuro-inflammation and, therefore, attenuates CIDS severity. In the later phase post CNS injury, CB 2 R inhibition is suggested as a promising pharmacologic strategy to restore immune function in order to prevent infection. ",

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Modulation of the endocannabinoid system following central nervous system injury

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Access to Document

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