Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights

Olusegun Isaac Alatise; Gregory C. Knapp; Avinash Sharma; Walid K. Chatila; Olukayode A. Arowolo; Olalekan Olasehinde; Olusola C. Famurewa; Adeleye D. Omisore; Akinwumi O. Komolafe; Olaejinrinde O. Olaofe; Aba I. Katung; David E. Ibikunle; Adedeji A. Egberongbe; Samuel A. Olatoke; Sulaiman O. Agodirin; Olusola A. Adesiyun; Ademola Adeyeye; Oladapo A. Kolawole; Akinwumi O. Olakanmi; Kanika Arora; Jeremy Constable; Ronak Shah; Azfar Basunia; Brooke Sylvester; Chao Wu; Martin R. Weiser; Ken Seier; Mithat Gonen; Zsofia K. Stadler; Yelena Kemel; Efsevia Vakiani; Michael F. Berger; Timothy A. Chan; David B. Solit; Jinru Shia; Francisco Sanchez-Vega; Nikolaus Schultz; Murray Brennan; J. Joshua Smith; T. Peter Kingham

doi:10.1038/s41467-021-27106-w

Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights

Olusegun Isaac Alatise, Gregory C. Knapp, Avinash Sharma, Walid K. Chatila, Olukayode A. Arowolo, Olalekan Olasehinde, Olusola C. Famurewa, Adeleye D. Omisore, Akinwumi O. Komolafe, Olaejinrinde O. Olaofe, Aba I. Katung, David E. Ibikunle, Adedeji A. Egberongbe, Samuel A. Olatoke, Sulaiman O. Agodirin, Olusola A. Adesiyun, Ademola Adeyeye, Oladapo A. Kolawole, Akinwumi O. Olakanmi, Kanika AroraJeremy Constable, Ronak Shah, Azfar Basunia, Brooke Sylvester, Chao Wu, Martin R. Weiser, Ken Seier, Mithat Gonen, Zsofia K. Stadler, Yelena Kemel, Efsevia Vakiani, Michael F. Berger, Timothy A. Chan, David B. Solit, Jinru Shia, Francisco Sanchez-Vega, Nikolaus Schultz, Murray Brennan, J. Joshua Smith, T. Peter Kingham

Medicine

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West Africa is vital to addressing the regions rising burden of disease. Tissue from unselected Nigerian patients was analyzed with a multigene, next-generation sequencing assay. The rate of microsatellite instability is significantly higher among Nigerian CRC patients (28.1%) than patients from The Cancer Genome Atlas (TCGA, 14.2%) and Memorial Sloan Kettering Cancer Center (MSKCC, 8.5%, P < 0.001). In microsatellite-stable cases, tumors from Nigerian patients are less likely to have APC mutations (39.1% vs. 76.0% MSKCC P < 0.001) and WNT pathway alterations (47.8% vs. 81.9% MSKCC, P < 0.001); whereas RAS pathway alteration is more prevalent (76.1% vs. 59.6%, P = 0.03). Nigerian CRC patients are also younger and more likely to present with rectal disease (50.8% vs. 33.7% MSKCC, P < 0.001). The findings suggest a unique biology of CRC in Nigeria, which emphasizes the need for regional data to guide diagnostic and treatment approaches for patients in West Africa.

Original language	English
Article number	6821
Journal	Nature Communications
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41467-021-27106-w
Publication status	Published - Dec 2021

Bibliographical note

Funding Information:
The authors would like to acknowledge our partners within the African Research Group for Oncology (https://www.argo-research.org/institutional-partners/) and the research team at Obafemi Awolowo University Teaching Hospital Complex, including Gbenga Samson, Olalude Olawale, and Busayo. The authors would also like to recognize Agnes Viale, PhD and S. Duygu Selcuklu, PhD at the Marie-Jose and Henry R. Kravis Center for Molecular Oncology at Memorial Sloan Kettering Cancer Center for assistance with specimen collection, data management/generation, and project management. Erin Pat-terson, PhD (Memorial Sloan Kettering Cancer Center) provided editorial assistance. This research was funded in part by Memorial Sloan Kettering Cancer Center (MSKCC) with support from the Thompson Family Foundation, an MSKCC Population Science Research Grant, and the NIH/NCI Cancer Center Support Grant P30 CA008748.

Publisher Copyright:
© 2021, The Author(s).

ASJC Scopus Subject Areas

General Chemistry
General Biochemistry,Genetics and Molecular Biology
General Physics and Astronomy

PubMed: MeSH publication types

Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41467-021-27106-w

Cite this

Alatise, O. I., Knapp, G. C., Sharma, A., Chatila, W. K., Arowolo, O. A., Olasehinde, O., Famurewa, O. C., Omisore, A. D., Komolafe, A. O., Olaofe, O. O., Katung, A. I., Ibikunle, D. E., Egberongbe, A. A., Olatoke, S. A., Agodirin, S. O., Adesiyun, O. A., Adeyeye, A., Kolawole, O. A., Olakanmi, A. O., ... Kingham, T. P. (2021). Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights. Nature Communications, 12(1), Article 6821. https://doi.org/10.1038/s41467-021-27106-w

Alatise, OI, Knapp, GC, Sharma, A, Chatila, WK, Arowolo, OA, Olasehinde, O, Famurewa, OC, Omisore, AD, Komolafe, AO, Olaofe, OO, Katung, AI, Ibikunle, DE, Egberongbe, AA, Olatoke, SA, Agodirin, SO, Adesiyun, OA, Adeyeye, A, Kolawole, OA, Olakanmi, AO, Arora, K, Constable, J, Shah, R, Basunia, A, Sylvester, B, Wu, C, Weiser, MR, Seier, K, Gonen, M, Stadler, ZK, Kemel, Y, Vakiani, E, Berger, MF, Chan, TA, Solit, DB, Shia, J, Sanchez-Vega, F, Schultz, N, Brennan, M, Smith, JJ & Kingham, TP 2021, 'Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights', Nature Communications, vol. 12, no. 1, 6821. https://doi.org/10.1038/s41467-021-27106-w

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title = "Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights",

abstract = "Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West Africa is vital to addressing the regions rising burden of disease. Tissue from unselected Nigerian patients was analyzed with a multigene, next-generation sequencing assay. The rate of microsatellite instability is significantly higher among Nigerian CRC patients (28.1%) than patients from The Cancer Genome Atlas (TCGA, 14.2%) and Memorial Sloan Kettering Cancer Center (MSKCC, 8.5%, P < 0.001). In microsatellite-stable cases, tumors from Nigerian patients are less likely to have APC mutations (39.1% vs. 76.0% MSKCC P < 0.001) and WNT pathway alterations (47.8% vs. 81.9% MSKCC, P < 0.001); whereas RAS pathway alteration is more prevalent (76.1% vs. 59.6%, P = 0.03). Nigerian CRC patients are also younger and more likely to present with rectal disease (50.8% vs. 33.7% MSKCC, P < 0.001). The findings suggest a unique biology of CRC in Nigeria, which emphasizes the need for regional data to guide diagnostic and treatment approaches for patients in West Africa.",

author = "Alatise, {Olusegun Isaac} and Knapp, {Gregory C.} and Avinash Sharma and Chatila, {Walid K.} and Arowolo, {Olukayode A.} and Olalekan Olasehinde and Famurewa, {Olusola C.} and Omisore, {Adeleye D.} and Komolafe, {Akinwumi O.} and Olaofe, {Olaejinrinde O.} and Katung, {Aba I.} and Ibikunle, {David E.} and Egberongbe, {Adedeji A.} and Olatoke, {Samuel A.} and Agodirin, {Sulaiman O.} and Adesiyun, {Olusola A.} and Ademola Adeyeye and Kolawole, {Oladapo A.} and Olakanmi, {Akinwumi O.} and Kanika Arora and Jeremy Constable and Ronak Shah and Azfar Basunia and Brooke Sylvester and Chao Wu and Weiser, {Martin R.} and Ken Seier and Mithat Gonen and Stadler, {Zsofia K.} and Yelena Kemel and Efsevia Vakiani and Berger, {Michael F.} and Chan, {Timothy A.} and Solit, {David B.} and Jinru Shia and Francisco Sanchez-Vega and Nikolaus Schultz and Murray Brennan and Smith, {J. Joshua} and Kingham, {T. Peter}",

note = "Funding Information: The authors would like to acknowledge our partners within the African Research Group for Oncology (https://www.argo-research.org/institutional-partners/) and the research team at Obafemi Awolowo University Teaching Hospital Complex, including Gbenga Samson, Olalude Olawale, and Busayo. The authors would also like to recognize Agnes Viale, PhD and S. Duygu Selcuklu, PhD at the Marie-Jose and Henry R. Kravis Center for Molecular Oncology at Memorial Sloan Kettering Cancer Center for assistance with specimen collection, data management/generation, and project management. Erin Pat-terson, PhD (Memorial Sloan Kettering Cancer Center) provided editorial assistance. This research was funded in part by Memorial Sloan Kettering Cancer Center (MSKCC) with support from the Thompson Family Foundation, an MSKCC Population Science Research Grant, and the NIH/NCI Cancer Center Support Grant P30 CA008748. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

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AU - Alatise, Olusegun Isaac

AU - Knapp, Gregory C.

AU - Sharma, Avinash

AU - Chatila, Walid K.

AU - Arowolo, Olukayode A.

AU - Olasehinde, Olalekan

AU - Famurewa, Olusola C.

AU - Omisore, Adeleye D.

AU - Komolafe, Akinwumi O.

AU - Olaofe, Olaejinrinde O.

AU - Katung, Aba I.

AU - Ibikunle, David E.

AU - Egberongbe, Adedeji A.

AU - Olatoke, Samuel A.

AU - Agodirin, Sulaiman O.

AU - Adesiyun, Olusola A.

AU - Adeyeye, Ademola

AU - Kolawole, Oladapo A.

AU - Olakanmi, Akinwumi O.

AU - Arora, Kanika

AU - Constable, Jeremy

AU - Shah, Ronak

AU - Basunia, Azfar

AU - Sylvester, Brooke

AU - Wu, Chao

AU - Weiser, Martin R.

AU - Seier, Ken

AU - Gonen, Mithat

AU - Stadler, Zsofia K.

AU - Kemel, Yelena

AU - Vakiani, Efsevia

AU - Berger, Michael F.

AU - Chan, Timothy A.

AU - Solit, David B.

AU - Shia, Jinru

AU - Sanchez-Vega, Francisco

AU - Schultz, Nikolaus

AU - Brennan, Murray

AU - Smith, J. Joshua

AU - Kingham, T. Peter

N1 - Funding Information: The authors would like to acknowledge our partners within the African Research Group for Oncology (https://www.argo-research.org/institutional-partners/) and the research team at Obafemi Awolowo University Teaching Hospital Complex, including Gbenga Samson, Olalude Olawale, and Busayo. The authors would also like to recognize Agnes Viale, PhD and S. Duygu Selcuklu, PhD at the Marie-Jose and Henry R. Kravis Center for Molecular Oncology at Memorial Sloan Kettering Cancer Center for assistance with specimen collection, data management/generation, and project management. Erin Pat-terson, PhD (Memorial Sloan Kettering Cancer Center) provided editorial assistance. This research was funded in part by Memorial Sloan Kettering Cancer Center (MSKCC) with support from the Thompson Family Foundation, an MSKCC Population Science Research Grant, and the NIH/NCI Cancer Center Support Grant P30 CA008748. Publisher Copyright: © 2021, The Author(s).

PY - 2021/12

Y1 - 2021/12

N2 - Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West Africa is vital to addressing the regions rising burden of disease. Tissue from unselected Nigerian patients was analyzed with a multigene, next-generation sequencing assay. The rate of microsatellite instability is significantly higher among Nigerian CRC patients (28.1%) than patients from The Cancer Genome Atlas (TCGA, 14.2%) and Memorial Sloan Kettering Cancer Center (MSKCC, 8.5%, P < 0.001). In microsatellite-stable cases, tumors from Nigerian patients are less likely to have APC mutations (39.1% vs. 76.0% MSKCC P < 0.001) and WNT pathway alterations (47.8% vs. 81.9% MSKCC, P < 0.001); whereas RAS pathway alteration is more prevalent (76.1% vs. 59.6%, P = 0.03). Nigerian CRC patients are also younger and more likely to present with rectal disease (50.8% vs. 33.7% MSKCC, P < 0.001). The findings suggest a unique biology of CRC in Nigeria, which emphasizes the need for regional data to guide diagnostic and treatment approaches for patients in West Africa.

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Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

Access to Document

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