Molecular control of leukocyte trafficking internal regulatory circuits of the immune system: Leukocyte circulation and homing

Steven E. Bosinger, Karoline A. Hoisawa, Cheryl M. Cameron, Marke Devries, Jeff C. Coombs, Mark J. Cameron, David J. Kelvin

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Leukocyte migration is essential for their ability to react to inflammatory stimuli at various locations within the body. However, leukocyte movement is also crucial during non-inflammatory processes such as haematopoietic development and routine passage through secoandary lymphoid organs, which is the key to effective antigen presentation. The importance of cell migration in the establishment and maintenance of an intact immune system has been demonstrated by numerous observations of immune defects in chemokine receptor deficient mice. This review describes the role of chemokines, their receptors and adhesion molecules in the regulation of the immune response during inflammatory and homeostatic conditions. In particular, we describe the molecular events regulating the recruitment of innate cells in response to infection and inflammation, leukocyte trafficking during development processes such as haematopoiesis and thymic naturation of T cells, and regulatory circuits that ensure immune surveillance and communication between innade and adaptive components of immunity.

Original languageEnglish
Title of host publicationNeuroImmune Biology
PublisherElsevier
Pages185-214
Number of pages30
EditionC
DOIs
Publication statusPublished - 2005
Externally publishedYes

Publication series

NameNeuroImmune Biology
NumberC
Volume5
ISSN (Print)1567-7443

Bibliographical note

Funding Information:
This work was supported by grants from the Heart and Stroke Foundation of Canada, the Canadian Institutes of Health Research, and Genome Canada. SEB is funded by the National Sciences and Engineering Research Council of Canada and the Canadian Institutes of Health Research. KAH is funded by Ontario Graduate Scholarship Program.

ASJC Scopus Subject Areas

  • Immunology
  • Neurology
  • Clinical Neurology

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